CXCR5 identifies a subset of Vgamma9 Vdelta2 T cells which secrete IL-4 andIL-10 and help B cells for antibody production.

Francesco Dieli, Nadia Rosalia Caccamo, Serena Meraviglia, Carmela La Mendola, Alfredo Salerno, Emmanuel Scotet, Giovanna Borsellino, Luca Battistini, Richard A. Kroczek, Jean Jacques Fournié, Fabrizio Poccia, Marc Bonneville

Risultato della ricerca: Articlepeer review

91 Citazioni (Scopus)

Abstract

Vgamma9Vdelta2 T lymphocytes recognize nonpeptidic Ags and mount effector functions in cellular immune responses against microorganisms and tumors, but little is known about their role in Ab-mediated immune responses. We show here that expression of CXCR5 identifies a unique subset of Vgamma9Vdelta2 T cells which express the costimulatory molecules ICOS and CD40L, secrete IL-2, IL-4, and IL-10 and help B cells for Ab production. These properties portray CXCR5+ Vgamma9Vdelta2 T cells as a distinct memory T cell subset with B cell helper function.
Lingua originaleUndefined/Unknown
pagine (da-a)5290-5295
RivistaJournal of Immunology
Volume177
Stato di pubblicazionePublished - 2006

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology

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