Cut-off points of the visceral adiposity index (VAI) identifying a visceral adipose dysfunction associated with cardiometabolic risk in a Caucasian Sicilian population.

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Abstract

Background: The Visceral Adiposity Index (VAI) is a sex-specific mathematical index, based on Waist Circumference(WC), Body Mass Index (BMI), triglycerides (TG) and HDL cholesterol (HDL) levels, indirectly expressing visceraladipose function and insulin sensitivity. Our aim was to find the optimal cut-off points of VAI identifying a visceraladipose dysfunction (VAD) associated with cardiometabolic risk in a Caucasian Sicilian population.Methods: Medical check-up data of 1,764 Primary Care patients (PC patients) were retrospectively and crosssectionallyexamined using a receiver-operating characteristic (ROC) curve to determine appropriate stratified-foragecut-off of VAI, for the identification of PC patients with Metabolic Syndrome (MetS) according to the NCEP-ATPIII criteria. The PC patients with higher VAI scores were subdivided into three groups according to VAI tertiles (i.e.PC patients with mild VAD, moderate VAD or severe VAD). Finally, VAD classes were compared to classical cardioandcerebrovascular risk factors as independent predictors of coronary heart disease and/or myocardial infarction,transient ischemic attack and/or ischemic stroke.Results: Moderate and severe VADs proved to be independently associated with cardiovascular events [(OR: 5.35;95% CI: 1.92-14.87; p = 0.001) and (OR: 7.46; 95% CI: 2.64-21.05; p < 0.001) respectively]. Mild, moderate and severeVADs were found to be independently associated with cerebrovascular events [(OR: 2.73; 95% CI: 1.12-6.65; p =0.027), (OR: 4.20; 95% CI: 1.86-9.45; p = 0.001) and (OR: 5.10; 95% CI: 2.14-12.17; p < 0.001) respectively].Conclusions: Our study suggests that among Caucasian Sicilian subjects there are clear cut-off points of VAI ableto identify a VAD strongly associated with cardiometabolic risk.Keywords: Obesity, cardiometabolic risk, visceral adipose dynsfunction, VAI
Lingua originaleEnglish
Numero di pagine8
RivistaLipids in Health and Disease
Volume10
Stato di pubblicazionePublished - 2011

All Science Journal Classification (ASJC) codes

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology
  • Clinical Biochemistry
  • Biochemistry, medical

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