Curcumin induces selective packaging of miR-21 in exosomes released by Chronic Myelogenous Leukemia cells

Marzia Pucci; Riccardo Alessandro; Marco Giallombardo; Simona Taverna; Giacomo De Leo; Christian Diego Rolfo

Curcumin induces selective packaging of miR-21 in exosomes released by Chronic Myelogenous Leukemia cells

Marzia Pucci, Riccardo Alessandro, Marco Giallombardo, Simona Taverna, Giacomo De Leo, Christian Diego Rolfo

Risultato della ricerca: Other › peer review

Abstract

Chronic myeloid leukemia is a myeloproliferative disorder that comes from a hematopoietic stem cell or a multipotent progenitor. Exosomes are biological nanovescicles (40-100 nm) able to modulate intercellular communication and tumour microenvironment; they also contain miRNAs that can influence gene expression in target cells. OncomiRNAs, such as miR-21, are often increased in cancer. Some observation indicate a possible cellular disposal of miRNAs by exosomes. Curcumin affects the expression of microRNAs in CML cells and according to our data may play a role in this process.

Lingua originale	English
Numero di pagine	1
Stato di pubblicazione	Published - 2015

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@conference{5a3475ef8bfc4327ad40a64fb17b94c6,

title = "Curcumin induces selective packaging of miR-21 in exosomes released by Chronic Myelogenous Leukemia cells",

abstract = "Chronic myeloid leukemia is a myeloproliferative disorder that comes from a hematopoietic stem cell or a multipotent progenitor. Exosomes are biological nanovescicles (40-100 nm) able to modulate intercellular communication and tumour microenvironment; they also contain miRNAs that can influence gene expression in target cells. OncomiRNAs, such as miR-21, are often increased in cancer. Some observation indicate a possible cellular disposal of miRNAs by exosomes. Curcumin affects the expression of microRNAs in CML cells and according to our data may play a role in this process.",

author = "Marzia Pucci and Riccardo Alessandro and Marco Giallombardo and Simona Taverna and {De Leo}, Giacomo and Rolfo, {Christian Diego}",

year = "2015",

language = "English",

}

TY - CONF

T1 - Curcumin induces selective packaging of miR-21 in exosomes released by Chronic Myelogenous Leukemia cells

AU - Pucci, Marzia

AU - Alessandro, Riccardo

AU - Giallombardo, Marco

AU - Taverna, Simona

AU - De Leo, Giacomo

AU - Rolfo, Christian Diego

PY - 2015

Y1 - 2015

N2 - Chronic myeloid leukemia is a myeloproliferative disorder that comes from a hematopoietic stem cell or a multipotent progenitor. Exosomes are biological nanovescicles (40-100 nm) able to modulate intercellular communication and tumour microenvironment; they also contain miRNAs that can influence gene expression in target cells. OncomiRNAs, such as miR-21, are often increased in cancer. Some observation indicate a possible cellular disposal of miRNAs by exosomes. Curcumin affects the expression of microRNAs in CML cells and according to our data may play a role in this process.

AB - Chronic myeloid leukemia is a myeloproliferative disorder that comes from a hematopoietic stem cell or a multipotent progenitor. Exosomes are biological nanovescicles (40-100 nm) able to modulate intercellular communication and tumour microenvironment; they also contain miRNAs that can influence gene expression in target cells. OncomiRNAs, such as miR-21, are often increased in cancer. Some observation indicate a possible cellular disposal of miRNAs by exosomes. Curcumin affects the expression of microRNAs in CML cells and according to our data may play a role in this process.

UR - http://hdl.handle.net/10447/176140

M3 - Other

ER -