Crucial role of interleukin-4 in the survival of colon cancer stem cells

Matilde Todaro, Giorgio Stassi, Mileidys Perez Alea, Maria Giovanna Francipane, Ylenia Lombardo, Giorgio Stassi, Jan Paul Medema, Matilde Todaro

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Abstract

Colon tumors may be maintained by a rare fraction of cancerstem-like cells (CSC) that express the cell surface markerCD133. Self-renewing CSCs exhibit relatively greater resistanceto clinical cytotoxic therapies and recent work suggests thatthis resistance may be mediated in part by an autocrineresponse to the immune cytokine interleukin 4 (IL-4). BlockingIL-4 signaling can sensitize CSCs to apoptotic stimuliand increase the in vivo efficacy of cytotoxic therapy. Thesefindings suggest that inhibitors of IL-4 signaling may offer anew therapeutic tool in colon carcinoma
Lingua originaleEnglish
pagine (da-a)4022-4025
Numero di pagine4
RivistaCancer Research
Volume68
Stato di pubblicazionePublished - 2008

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All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

Cita questo

Todaro, M., Stassi, G., Alea, M. P., Francipane, M. G., Lombardo, Y., Stassi, G., Medema, J. P., & Todaro, M. (2008). Crucial role of interleukin-4 in the survival of colon cancer stem cells. Cancer Research, 68, 4022-4025.