CROHN'S DISEASE AND EXTRAINTESTINAL GRANULOMATOUS LESIONS

Emanuele Sinagra, Angelo Leone, Giovanni Tomasello, Alice Gerges, Francesco Carini, Angelo Leone, Provvidenza Damiani, Emanuele Sinagra, Margherita Mazzola, Scaglione, Gagliardo, Gerges Geaga, Tomasello, Jurjus, Francesco Carini, Provvidenza Damiani

Risultato della ricerca: Article

Abstract

Crohn's disease (CD) is an inflammatory bowel disease with a multifactorial etiology. Clinical features include mucosal erosion, diarrhea, weight loss and other complications such as formation of granuloma. in CD, granuloma is a non-neoplastic epithelioid lesio, formed by a compact aggregate of histiocytes with the absence of a central necrosis, however, the correlation amomg CD and the formation of granulomas is unknown. Many casesof granulomas in the extracellular site, related to Cd, have been reported in the literature. These granulomas, at times, rapresented the only visible manifestation of the pathology. extra intestinal granuloma have been found on ovaries, lungs, male genitalia, female genitalia, orofacial region and skin. From the data in the literature it could be hypothesized that there is a cross-reaction of the imune system with similar antigenic epitopes belonging to different sites. This hypothesis, if checked, can place CD not only among inflammatory bowel disease but also among inflammatory diseases with systemic involvement.
Lingua originaleEnglish
pagine (da-a)7-11
Numero di pagine5
RivistaDefault journal
Volume32
Stato di pubblicazionePublished - 2018

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Granuloma
Crohn Disease
Inflammatory Bowel Diseases
Male Genitalia
Female Genitalia
Histiocytes
Cross Reactions
Weight Loss
Epitopes
Ovary
Diarrhea
Necrosis
Pathology
Lung
Skin

All Science Journal Classification (ASJC) codes

  • Endocrinology, Diabetes and Metabolism
  • Immunology and Allergy
  • Physiology
  • Immunology
  • Oncology
  • Endocrinology
  • Physiology (medical)
  • Cancer Research

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CROHN'S DISEASE AND EXTRAINTESTINAL GRANULOMATOUS LESIONS. / Sinagra, Emanuele; Leone, Angelo; Tomasello, Giovanni; Gerges, Alice; Carini, Francesco; Leone, Angelo; Damiani, Provvidenza; Sinagra, Emanuele; Mazzola, Margherita; Scaglione; Gagliardo; Gerges Geaga; Tomasello; Jurjus; Carini, Francesco; Damiani, Provvidenza.

In: Default journal, Vol. 32, 2018, pag. 7-11.

Risultato della ricerca: Article

Sinagra, E, Leone, A, Tomasello, G, Gerges, A, Carini, F, Leone, A, Damiani, P, Sinagra, E, Mazzola, M, Scaglione, Gagliardo, Gerges Geaga, Tomasello, Jurjus, Carini, F & Damiani, P 2018, 'CROHN'S DISEASE AND EXTRAINTESTINAL GRANULOMATOUS LESIONS', Default journal, vol. 32, pagg. 7-11.
Sinagra, Emanuele ; Leone, Angelo ; Tomasello, Giovanni ; Gerges, Alice ; Carini, Francesco ; Leone, Angelo ; Damiani, Provvidenza ; Sinagra, Emanuele ; Mazzola, Margherita ; Scaglione ; Gagliardo ; Gerges Geaga ; Tomasello ; Jurjus ; Carini, Francesco ; Damiani, Provvidenza. / CROHN'S DISEASE AND EXTRAINTESTINAL GRANULOMATOUS LESIONS. In: Default journal. 2018 ; Vol. 32. pagg. 7-11.
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author = "Emanuele Sinagra and Angelo Leone and Giovanni Tomasello and Alice Gerges and Francesco Carini and Angelo Leone and Provvidenza Damiani and Emanuele Sinagra and Margherita Mazzola and Scaglione and Gagliardo and {Gerges Geaga} and Tomasello and Jurjus and Francesco Carini and Provvidenza Damiani",
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AU - Sinagra, Emanuele

AU - Leone, Angelo

AU - Tomasello, Giovanni

AU - Gerges, Alice

AU - Carini, Francesco

AU - Leone, Angelo

AU - Damiani, Provvidenza

AU - Sinagra, Emanuele

AU - Mazzola, Margherita

AU - Scaglione, null

AU - Gagliardo, null

AU - Gerges Geaga, null

AU - Tomasello, null

AU - Jurjus, null

AU - Carini, Francesco

AU - Damiani, Provvidenza

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AB - Crohn's disease (CD) is an inflammatory bowel disease with a multifactorial etiology. Clinical features include mucosal erosion, diarrhea, weight loss and other complications such as formation of granuloma. in CD, granuloma is a non-neoplastic epithelioid lesio, formed by a compact aggregate of histiocytes with the absence of a central necrosis, however, the correlation amomg CD and the formation of granulomas is unknown. Many casesof granulomas in the extracellular site, related to Cd, have been reported in the literature. These granulomas, at times, rapresented the only visible manifestation of the pathology. extra intestinal granuloma have been found on ovaries, lungs, male genitalia, female genitalia, orofacial region and skin. From the data in the literature it could be hypothesized that there is a cross-reaction of the imune system with similar antigenic epitopes belonging to different sites. This hypothesis, if checked, can place CD not only among inflammatory bowel disease but also among inflammatory diseases with systemic involvement.

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