CROHN'S DISEASE AND EXTRAINTESTINAL GRANULOMATOUS LESIONS

Francesco Carini, Angelo Leone, Giovanni Tomasello, Emanuele Sinagra, Provvidenza Damiani, Alice Gerges, Jurjus, Provvidenza Damiani, Emanuele Sinagra, Gagliardo, Gerges Geaga

Risultato della ricerca: Article

Abstract

Crohn's disease (CD) is an inflammatory bowel disease with a multifactorial etiology. Clinical features include mucosal erosion, diarrhea, weight loss and other complications such as formation of granuloma. in CD, granuloma is a non-neoplastic epithelioid lesio, formed by a compact aggregate of histiocytes with the absence of a central necrosis, however, the correlation amomg CD and the formation of granulomas is unknown. Many casesof granulomas in the extracellular site, related to Cd, have been reported in the literature. These granulomas, at times, rapresented the only visible manifestation of the pathology. extra intestinal granuloma have been found on ovaries, lungs, male genitalia, female genitalia, orofacial region and skin. From the data in the literature it could be hypothesized that there is a cross-reaction of the imune system with similar antigenic epitopes belonging to different sites. This hypothesis, if checked, can place CD not only among inflammatory bowel disease but also among inflammatory diseases with systemic involvement.
Lingua originaleEnglish
pagine (da-a)7-11
Numero di pagine5
RivistaJOURNAL OF BIOLOGICAL REGULATORS & HOMEOSTATIC AGENTS
Volume32
Stato di pubblicazionePublished - 2018

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Granuloma
Crohn Disease
Inflammatory Bowel Diseases
Male Genitalia
Female Genitalia
Histiocytes
Cross Reactions
Weight Loss
Epitopes
Ovary
Diarrhea
Necrosis
Pathology
Lung
Skin

All Science Journal Classification (ASJC) codes

  • Endocrinology, Diabetes and Metabolism
  • Cancer Research
  • Physiology (medical)
  • Endocrinology
  • Oncology
  • Immunology
  • Physiology
  • Immunology and Allergy

Cita questo

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title = "CROHN'S DISEASE AND EXTRAINTESTINAL GRANULOMATOUS LESIONS",
abstract = "Crohn's disease (CD) is an inflammatory bowel disease with a multifactorial etiology. Clinical features include mucosal erosion, diarrhea, weight loss and other complications such as formation of granuloma. in CD, granuloma is a non-neoplastic epithelioid lesio, formed by a compact aggregate of histiocytes with the absence of a central necrosis, however, the correlation amomg CD and the formation of granulomas is unknown. Many casesof granulomas in the extracellular site, related to Cd, have been reported in the literature. These granulomas, at times, rapresented the only visible manifestation of the pathology. extra intestinal granuloma have been found on ovaries, lungs, male genitalia, female genitalia, orofacial region and skin. From the data in the literature it could be hypothesized that there is a cross-reaction of the imune system with similar antigenic epitopes belonging to different sites. This hypothesis, if checked, can place CD not only among inflammatory bowel disease but also among inflammatory diseases with systemic involvement.",
author = "Francesco Carini and Angelo Leone and Giovanni Tomasello and Emanuele Sinagra and Provvidenza Damiani and Alice Gerges and Jurjus and Provvidenza Damiani and Emanuele Sinagra and Gagliardo and {Gerges Geaga}",
year = "2018",
language = "English",
volume = "32",
pages = "7--11",
journal = "Journal of Biological Regulators and Homeostatic Agents",
issn = "0393-974X",
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TY - JOUR

T1 - CROHN'S DISEASE AND EXTRAINTESTINAL GRANULOMATOUS LESIONS

AU - Carini, Francesco

AU - Leone, Angelo

AU - Tomasello, Giovanni

AU - Sinagra, Emanuele

AU - Damiani, Provvidenza

AU - Gerges, Alice

AU - Jurjus, null

AU - Damiani, Provvidenza

AU - Sinagra, Emanuele

AU - Gagliardo, null

AU - Gerges Geaga, null

PY - 2018

Y1 - 2018

N2 - Crohn's disease (CD) is an inflammatory bowel disease with a multifactorial etiology. Clinical features include mucosal erosion, diarrhea, weight loss and other complications such as formation of granuloma. in CD, granuloma is a non-neoplastic epithelioid lesio, formed by a compact aggregate of histiocytes with the absence of a central necrosis, however, the correlation amomg CD and the formation of granulomas is unknown. Many casesof granulomas in the extracellular site, related to Cd, have been reported in the literature. These granulomas, at times, rapresented the only visible manifestation of the pathology. extra intestinal granuloma have been found on ovaries, lungs, male genitalia, female genitalia, orofacial region and skin. From the data in the literature it could be hypothesized that there is a cross-reaction of the imune system with similar antigenic epitopes belonging to different sites. This hypothesis, if checked, can place CD not only among inflammatory bowel disease but also among inflammatory diseases with systemic involvement.

AB - Crohn's disease (CD) is an inflammatory bowel disease with a multifactorial etiology. Clinical features include mucosal erosion, diarrhea, weight loss and other complications such as formation of granuloma. in CD, granuloma is a non-neoplastic epithelioid lesio, formed by a compact aggregate of histiocytes with the absence of a central necrosis, however, the correlation amomg CD and the formation of granulomas is unknown. Many casesof granulomas in the extracellular site, related to Cd, have been reported in the literature. These granulomas, at times, rapresented the only visible manifestation of the pathology. extra intestinal granuloma have been found on ovaries, lungs, male genitalia, female genitalia, orofacial region and skin. From the data in the literature it could be hypothesized that there is a cross-reaction of the imune system with similar antigenic epitopes belonging to different sites. This hypothesis, if checked, can place CD not only among inflammatory bowel disease but also among inflammatory diseases with systemic involvement.

UR - http://hdl.handle.net/10447/289724

M3 - Article

VL - 32

SP - 7

EP - 11

JO - Journal of Biological Regulators and Homeostatic Agents

JF - Journal of Biological Regulators and Homeostatic Agents

SN - 0393-974X

ER -