Could growth hormone play a role in Peutz Jeghers syndrome?

Emanuele Sinagra, Mario Cottone, Emanuele Sinagra, Andrea Scalisi, Alessandra Santoro, Chiara Anna Rizzolo, Marco Giunta

    Risultato della ricerca: Articlepeer review


    Convincing experimental data suggest that the growth hormone (GH)/insulin-like growth factor-1(IGF-1) axis plays an important role in cancer development and behaviour. Epidemiological studies have supported an association with cancer, but not with tumour induction per se, although this is a distinction that is important mechanistically but not clinically [1].We report the case of a 17-year-old man with delayed growth of pituitary origin, treated with growth hormone, in whom a diagnosis of Peutz-Jeghers syndrome (PJS) was subsequently made, and in whom, during the endoscopic follow-up, the number of polyps reduced dramatically, thus suggesting a role for GH in eliciting this disease.
    Lingua originaleEnglish
    pagine (da-a)966-967
    Numero di pagine2
    RivistaMedical Hypotheses
    Stato di pubblicazionePublished - 2013

    All Science Journal Classification (ASJC) codes

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