Could growth hormone play a role in Peutz Jeghers syndrome?

Emanuele Sinagra, Marco Giunta, Mario Cottone, Emanuele Sinagra, Andrea Scalisi, Alessandra Santoro, Chiara Anna Rizzolo

    Risultato della ricerca: Article

    Abstract

    Convincing experimental data suggest that the growth hormone (GH)/insulin-like growth factor-1(IGF-1) axis plays an important role in cancer development and behaviour. Epidemiological studies have supported an association with cancer, but not with tumour induction per se, although this is a distinction that is important mechanistically but not clinically [1]. We report the case of a 17-year-old man with delayed growth of pituitary origin, treated with growth hormone, in whom a diagnosis of Peutz-Jeghers syndrome (PJS) was subsequently made, and in whom, during the endoscopic follow-up, the number of polyps reduced dramatically, thus suggesting a role for GH in eliciting this disease.
    Lingua originaleEnglish
    pagine (da-a)966-967
    Numero di pagine2
    RivistaMedical Hypotheses
    Volume81
    Stato di pubblicazionePublished - 2013

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    Peutz-Jeghers Syndrome
    Growth Hormone
    Neoplasms
    Somatomedins
    Polyps
    Epidemiologic Studies
    Growth

    All Science Journal Classification (ASJC) codes

    • Medicine(all)

    Cita questo

    Sinagra, E., Giunta, M., Cottone, M., Sinagra, E., Scalisi, A., Santoro, A., & Rizzolo, C. A. (2013). Could growth hormone play a role in Peutz Jeghers syndrome? Medical Hypotheses, 81, 966-967.

    Could growth hormone play a role in Peutz Jeghers syndrome? / Sinagra, Emanuele; Giunta, Marco; Cottone, Mario; Sinagra, Emanuele; Scalisi, Andrea; Santoro, Alessandra; Rizzolo, Chiara Anna.

    In: Medical Hypotheses, Vol. 81, 2013, pag. 966-967.

    Risultato della ricerca: Article

    Sinagra, E, Giunta, M, Cottone, M, Sinagra, E, Scalisi, A, Santoro, A & Rizzolo, CA 2013, 'Could growth hormone play a role in Peutz Jeghers syndrome?', Medical Hypotheses, vol. 81, pagg. 966-967.
    Sinagra E, Giunta M, Cottone M, Sinagra E, Scalisi A, Santoro A e altri. Could growth hormone play a role in Peutz Jeghers syndrome? Medical Hypotheses. 2013;81:966-967.
    Sinagra, Emanuele ; Giunta, Marco ; Cottone, Mario ; Sinagra, Emanuele ; Scalisi, Andrea ; Santoro, Alessandra ; Rizzolo, Chiara Anna. / Could growth hormone play a role in Peutz Jeghers syndrome?. In: Medical Hypotheses. 2013 ; Vol. 81. pagg. 966-967.
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    AU - Giunta, Marco

    AU - Cottone, Mario

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    AU - Scalisi, Andrea

    AU - Santoro, Alessandra

    AU - Rizzolo, Chiara Anna

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    AB - Convincing experimental data suggest that the growth hormone (GH)/insulin-like growth factor-1(IGF-1) axis plays an important role in cancer development and behaviour. Epidemiological studies have supported an association with cancer, but not with tumour induction per se, although this is a distinction that is important mechanistically but not clinically [1]. We report the case of a 17-year-old man with delayed growth of pituitary origin, treated with growth hormone, in whom a diagnosis of Peutz-Jeghers syndrome (PJS) was subsequently made, and in whom, during the endoscopic follow-up, the number of polyps reduced dramatically, thus suggesting a role for GH in eliciting this disease.

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