Cortical inhibition and habituation to evoked potentials: relevance for pathophysiology of migraine.

Risultato della ricerca: Articlepeer review

67 Citazioni (Scopus)

Abstract

Dysfunction of neuronal cortical excitability has been supposed to play an important role in etiopathogenesis of migraine. Neurophysiological techniques like evoked potentials (EP) and in the last years non-invasive brain stimulation techniques like transcranial magnetic stimulation (TMS) and transcranial direct current stimulation gave important contribution to understanding of such issue highlighting possible mechanisms of cortical dysfunctions in migraine. EP studies showed impaired habituation to repeated sensorial stimulation and this abnormality was confirmed across all sensorial modalities, making defective habituation a neurophysiological hallmark of the disease. TMS was employed to test more directly cortical excitability in visual cortex and then also in motor cortex. Contradictory results have been reported pointing towards hyperexcitability or on the contrary to reduced preactivation of sensory cortex in migraine. Other experimental evidence speaks in favour of impairment of inhibitory circuits and analogies have been proposed between migraine and conditions of sensory deafferentation in which down-regulation of GABA circuits is considered the more relevant pathophysiological mechanism. Whatever the mechanism involved, it has been found that repeated sessions of high-frequency rTMS trains that have been shown to up-regulate inhibitory circuits could persistently normalize habituation in migraine. This could give interesting insight into pathophysiology establishing a link between cortical inhibition and habituation and opening also new treatment strategies in migraine.
Lingua originaleEnglish
pagine (da-a)77-84
Numero di pagine8
RivistaTHE JOURNAL OF HEADACHE AND PAIN
Volume10
Stato di pubblicazionePublished - 2009

All Science Journal Classification (ASJC) codes

  • ???subjectarea.asjc.2700.2728???
  • ???subjectarea.asjc.2700.2703???

Fingerprint

Entra nei temi di ricerca di 'Cortical inhibition and habituation to evoked potentials: relevance for pathophysiology of migraine.'. Insieme formano una fingerprint unica.

Cita questo