Correlation between polymorphism of TYMS gene and toxicity response to treatment with 5-fluoruracil and capecitabine

Alessandra Amato, Patrizia Proia, Carlo Maria Di Liegro, Gabriella Schiera, Italia Di Liegro, Giuseppe Messina, Maria Rita Ricciardi, Chiara Verga, Stefano Vitello, Maria Rita Ricciardi

Risultato della ricerca: Articlepeer review


Tumorigenesis is a multiphasic process in which genetic alterations guide the progressive transformation in cancer cells1. In order to evaluate the possible correlation between some gene variants and the risk of the toxicity development onset, two of the polymorphisms of the thymidylate synthase (TYMS), rs34743033 (2R/3R) and rs16430 (DEL/INS) were investigated. We enrolled in our study 47 patients from the Hospital of Sicily. Our preliminary findings suggest that there could be a linkage between the genotypes discussed and the development of the toxicity following the chemotherapy treatment. These results need to be confirmed by further studies, however this short paper offers some initial insight into the relationships between genetic background and the better outcome for patients..
Lingua originaleEnglish
Numero di pagine5
RivistaEuropean Journal of Translational Myology
Stato di pubblicazionePublished - 2020

All Science Journal Classification (ASJC) codes

  • Orthopedics and Sports Medicine
  • Molecular Biology
  • Clinical Neurology
  • Cell Biology

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