Correlation between GP-170 expression, prognosis, and chemoresistance of superficial bladder carcinoma

Rossana Porcasi, Rosa Maria Tomasino, Rosario Sanguedolce, Marco Vella, Vincenza Morello, Rosalinda Allegro, Vincenzo Serretta, Carlo Pavone, Michele Pavone-Macaluso, Rosario Sanguedolce, Carlo Pavone, Marco Vella, Vincenzo Serretta, Michele Pavone

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10 Citazioni (Scopus)

Abstract

Purpose. To study GP-170 in superficial bladder cancer at initial diagnosis and at recurrence and to evaluate if intravesical chemoprophylaxis modifies the expression of GP-170 in tumor recurrence. Materials and Methods. GP-170 was retrospectively assessed in 160 patients affected by primary superficial transitional cell carcinoma of the bladder and followed for up to 10 years. Eighty-four patients (52.5%) recurred after transurethral resection (TUR). Adjuvant intravesical chemotherapy after TUR was adopted in 52 patients. The correlations between GP-170 expression and G-grade and T-category was found. A significant correlation was detected between GP-170 levels were also associated with an increasing risk of recurrence. Intravesical chemotherapy did not induce significative variations in GP-170 expression. No correlation was found between progression and GP-170. Conclusion. GP-170 seems to be an independent prognostic factor for recurrence in superficial bladder tumors. A negative GP-10 pattern and high levels of GP-170 are associated with an increasing risk of recurrence but have no impact upon progression. In our experience, GP-170 is neither induced nor modified by intravesical chemotherapy, although it might represent a factor of chemoresistance when strongly expressed.
Lingua originaleEnglish
pagine (da-a)472-476
Numero di pagine5
RivistaJournal of Cancer Research and Clinical Oncology
Volume129 (8)
Stato di pubblicazionePublished - 2003

All Science Journal Classification (ASJC) codes

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  • ???subjectarea.asjc.1300.1306???

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