A total of 62 patients at high risk for recurrence of superficial bladder cancer were selected for a study designed to compare the prophylactic efficacy of different doses and schedules of sequential intravesical instillations of epirubicin and interferon-alpha-2b and to evaluate which sequence could enhance the release of cytokines in the urine. Our investigations showed a significant increase in urinary concentrations of interleukins in patients who received the sequential intravesical administration of epirubicin and interferon-alpha-2b. Higher urinary concentrations of interleukins and a lower recurrence rate were detected in patients who received interferon-alpha-2b 24 h after epirubicin instillation. © 1993 Springer-Verlag.
|Numero di pagine||5|
|Stato di pubblicazione||Published - 1993|
All Science Journal Classification (ASJC) codes
Salerno, S., Serretta, V., Lio, D., Piazza, Serretta, V., & Piazza, B. (1993). Correlation between clinical response and urinary interleukin levels using different doses and intravesical administration schedules of interferon-alpha-2b combined with epirubicin: a pilot study. Urological Research, 21, 353-357.