Correlates of Human Herpesvirus-8 DNA detection among adults in Italy without Kaposi sarcoma

Francesco Vitale, Fabio Tramuto, Paola Cordiali Fei, Charles S. Rabkin, Concetta Castilletti, Lorenzo Gafa, James J. Goedert, Elizabeth E. Brown, Concetta Castilletti, Lorenzo Gafa, Lorenzo Gafa, Catia Valdarchi, Carmela Lauria, Pierluca Piselli, Anna Crispo, Paolo Ascierto, Michele Massimino, Anthony J. Alberg, Maria Rosaria De Marco, Rosa Maria CoronaMario Tamburini, Stefania Stella, Diego Serraino, Barbara Kroner, Denise Whitby, Mauizio Montella, Robert J. Biggar, Massimo Giuliani, Angelo Messina, Giovanni Rezza, Vickie Marshall, Carla Del Carpio, Sonia De Sicato, Caruso Laura

Risultato della ricerca: Articlepeer review

15 Citazioni (Scopus)

Abstract

Background: The presence of Human Herpesvirus-8 (HHV8) DNA is predictive of Kaposi sarcoma (KS) among patients with HIV-associated or iatrogenic immunosuppression. However, correlates of HHV8-DNA detection in the general population remain undefined. Methods: We assessed correlates of HHV8-DNA detection among Italian adults without KS who had antibodies against HHV8-latent nuclear antigen by immunofluorescence assay. HHV8-K6 DNA sequences were detected in peripheral blood mononuclear cells using TaqMan CR. Results: Of the 158 subjects 26 (16.5%) had detectable HHV8-DNA [median copies/million cells, 53; (13-2128)]. Adjusted for age, sex, and laboratory, HHV8-DNA was detected more frequently in participants with >7 total residents in the childhood home [OR = 3.7 (1.5-9.1)], >2 younger siblings [OR = 2.6 (1.1-6.5)], and current cardiovascular [OR = 3.6 (1.3-9.7)] or renal [OR = 3.1 (1.2-8.0)] disease. Excluding the participants using immune modulating drugs, HHV8-DNA was more frequent among those with low red blood cells (RBC) [<4.5 106/ μl; OR = 5.3 (1.7-16.2)], slightly elevated mean corpuscular volume [>92 μm3/red cell; OR = 2.8 (1.0-7.8)], and mild thrombocytopenia [<151 K/μl; OR = 5.6 1.9-16.3)]. Conclusions: Presence of HHV8-DNA in elderly Italians is associated with childhood crowding, low RBCs, and platelets, perhaps indicating roles for early infection and chronic inflammation. These risk factors are the first to be reported for non-immunosuppressed HHV8-seropositive adults.
Lingua originaleEnglish
pagine (da-a)1110-1117
Numero di pagine8
RivistaInternational Journal of Epidemiology
Volume34(5)
Stato di pubblicazionePublished - 2005

All Science Journal Classification (ASJC) codes

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