Convenient synthesis of pyrrolo[3,4-g]indazole

Virginia Spano', Paola Barraja, Patrizia Diana, Anna Carbone, Alessandra Montalbano, Barbara Parrino, Girolamo Cirrincione, Virginia Spanò, Barbara Parrino, Anna Carbone, Alessandra Montalbano, Paola Barraja, Girolamo Cirrincione, Patrizia Diana

Risultato della ricerca: Articlepeer review

15 Citazioni (Scopus)

Abstract

The synthesis of a novel class of tetrahydropyrrolo[3,4-g]indazoles is reported, by annelation of thepyrazole ring on the isoindole moiety by means of 5-hydroxymethylene tetrahydroisoindole-4-ones keyintermediates, with good regioselectivity. Dihydroderivatives were also obtained by oxidation with DDQof the corresponding tetrahydropyrrolo[3,4-g]indazoles. The growth inhibitory effect was evaluated atthe National Cancer Institute of Bethesda and some derivatives showed modest activity.
Lingua originaleEnglish
pagine (da-a)9839-9847
Numero di pagine9
RivistaTetrahedron
Volume69
Stato di pubblicazionePublished - 2013

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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