Convenient synthesis of pyrrolo[3,4-g]indazole

Anna Carbone; Paola Barraja; Girolamo Cirrincione; Patrizia Diana; Barbara Parrino; Alessandra Montalbano; Virginia Spano'; Virginia Spanò; Barbara Parrino; Anna Carbone; Alessandra Montalbano; Paola Barraja; Girolamo Cirrincione; Patrizia Diana

Convenient synthesis of pyrrolo[3,4-g]indazole

Anna Carbone, Paola Barraja, Girolamo Cirrincione, Patrizia Diana, Barbara Parrino, Alessandra Montalbano, Virginia Spano', Virginia Spanò, Barbara Parrino, Anna Carbone, Alessandra Montalbano, Paola Barraja, Girolamo Cirrincione, Patrizia Diana

Scienze e Tecnologie Biologiche Chimiche e Farmaceutiche

Risultato della ricerca: Article

13 Citazioni (Scopus)

Abstract

The synthesis of a novel class of tetrahydropyrrolo[3,4-g]indazoles is reported, by annelation of thepyrazole ring on the isoindole moiety by means of 5-hydroxymethylene tetrahydroisoindole-4-ones keyintermediates, with good regioselectivity. Dihydroderivatives were also obtained by oxidation with DDQof the corresponding tetrahydropyrrolo[3,4-g]indazoles. The growth inhibitory effect was evaluated atthe National Cancer Institute of Bethesda and some derivatives showed modest activity.

Lingua originale	English
pagine (da-a)	9839-9847
Numero di pagine	9
Rivista	Tetrahedron
Volume	69
Stato di pubblicazione	Published - 2013

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All Science Journal Classification (ASJC) codes

Biochemistry
Drug Discovery
Organic Chemistry

Cita questo

Carbone, A., Barraja, P., Cirrincione, G., Diana, P., Parrino, B., Montalbano, A., Spano', V., Spanò, V., Parrino, B., Carbone, A., Montalbano, A., Barraja, P., Cirrincione, G., & Diana, P. (2013). Convenient synthesis of pyrrolo[3,4-g]indazole. Tetrahedron, 69, 9839-9847.

Convenient synthesis of pyrrolo[3,4-g]indazole. / Carbone, Anna ; Barraja, Paola ; Cirrincione, Girolamo ; Diana, Patrizia ; Parrino, Barbara ; Montalbano, Alessandra ; Spano', Virginia; Spanò, Virginia; Parrino, Barbara; Carbone, Anna; Montalbano, Alessandra; Barraja, Paola; Cirrincione, Girolamo; Diana, Patrizia.

In: Tetrahedron, Vol. 69, 2013, pag. 9839-9847.

Risultato della ricerca: Article

Carbone, Anna ; Barraja, Paola ; Cirrincione, Girolamo ; Diana, Patrizia ; Parrino, Barbara ; Montalbano, Alessandra ; Spano', Virginia ; Spanò, Virginia ; Parrino, Barbara ; Carbone, Anna ; Montalbano, Alessandra ; Barraja, Paola ; Cirrincione, Girolamo ; Diana, Patrizia. / Convenient synthesis of pyrrolo[3,4-g]indazole. In: Tetrahedron. 2013 ; Vol. 69. pagg. 9839-9847.

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title = "Convenient synthesis of pyrrolo[3,4-g]indazole",

abstract = "The synthesis of a novel class of tetrahydropyrrolo[3,4-g]indazoles is reported, by annelation of thepyrazole ring on the isoindole moiety by means of 5-hydroxymethylene tetrahydroisoindole-4-ones keyintermediates, with good regioselectivity. Dihydroderivatives were also obtained by oxidation with DDQof the corresponding tetrahydropyrrolo[3,4-g]indazoles. The growth inhibitory effect was evaluated atthe National Cancer Institute of Bethesda and some derivatives showed modest activity.",

keywords = "4-g]indazole, Antiproliferative activity, Hydroxymethyleneketones, Regioselectivity, Tetrahydropyrrolo[3, 4-g]indazole, Antiproliferative activity, Hydroxymethyleneketones, Regioselectivity, Tetrahydropyrrolo[3",

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T1 - Convenient synthesis of pyrrolo[3,4-g]indazole

AU - Carbone, Anna

AU - Barraja, Paola

AU - Cirrincione, Girolamo

AU - Diana, Patrizia

AU - Parrino, Barbara

AU - Montalbano, Alessandra

AU - Spano', Virginia

AU - Spanò, Virginia

AU - Parrino, Barbara

AU - Carbone, Anna

AU - Montalbano, Alessandra

AU - Barraja, Paola

AU - Cirrincione, Girolamo

AU - Diana, Patrizia

PY - 2013

Y1 - 2013

N2 - The synthesis of a novel class of tetrahydropyrrolo[3,4-g]indazoles is reported, by annelation of thepyrazole ring on the isoindole moiety by means of 5-hydroxymethylene tetrahydroisoindole-4-ones keyintermediates, with good regioselectivity. Dihydroderivatives were also obtained by oxidation with DDQof the corresponding tetrahydropyrrolo[3,4-g]indazoles. The growth inhibitory effect was evaluated atthe National Cancer Institute of Bethesda and some derivatives showed modest activity.

AB - The synthesis of a novel class of tetrahydropyrrolo[3,4-g]indazoles is reported, by annelation of thepyrazole ring on the isoindole moiety by means of 5-hydroxymethylene tetrahydroisoindole-4-ones keyintermediates, with good regioselectivity. Dihydroderivatives were also obtained by oxidation with DDQof the corresponding tetrahydropyrrolo[3,4-g]indazoles. The growth inhibitory effect was evaluated atthe National Cancer Institute of Bethesda and some derivatives showed modest activity.

KW - 4-g]indazole

KW - Antiproliferative activity

KW - Hydroxymethyleneketones

KW - Regioselectivity

KW - Tetrahydropyrrolo[3

KW - 4-g]indazole

KW - Antiproliferative activity

KW - Hydroxymethyleneketones

KW - Regioselectivity

KW - Tetrahydropyrrolo[3

UR - http://hdl.handle.net/10447/83483

M3 - Article

VL - 69

SP - 9839

EP - 9847

JO - Tetrahedron

JF - Tetrahedron

SN - 0040-4020

ER -

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