Convenient synthesis of pyrrolo[3,4-g]indazole

Anna Carbone, Paola Barraja, Girolamo Cirrincione, Patrizia Diana, Barbara Parrino, Alessandra Montalbano, Virginia Spano', Virginia Spanò, Barbara Parrino, Anna Carbone, Alessandra Montalbano, Paola Barraja, Girolamo Cirrincione, Patrizia Diana

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Abstract

The synthesis of a novel class of tetrahydropyrrolo[3,4-g]indazoles is reported, by annelation of thepyrazole ring on the isoindole moiety by means of 5-hydroxymethylene tetrahydroisoindole-4-ones keyintermediates, with good regioselectivity. Dihydroderivatives were also obtained by oxidation with DDQof the corresponding tetrahydropyrrolo[3,4-g]indazoles. The growth inhibitory effect was evaluated atthe National Cancer Institute of Bethesda and some derivatives showed modest activity.
Lingua originaleEnglish
pagine (da-a)9839-9847
Numero di pagine9
RivistaTetrahedron
Volume69
Stato di pubblicazionePublished - 2013

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All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

Cita questo

Carbone, A., Barraja, P., Cirrincione, G., Diana, P., Parrino, B., Montalbano, A., Spano', V., Spanò, V., Parrino, B., Carbone, A., Montalbano, A., Barraja, P., Cirrincione, G., & Diana, P. (2013). Convenient synthesis of pyrrolo[3,4-g]indazole. Tetrahedron, 69, 9839-9847.