Convenient synthesis of pyrrolo[3,4-g]indazole

Virginia Spano'; Paola Barraja; Patrizia Diana; Anna Carbone; Alessandra Montalbano; Barbara Parrino; Girolamo Cirrincione; Virginia Spanò; Barbara Parrino; Anna Carbone; Alessandra Montalbano; Paola Barraja; Girolamo Cirrincione; Patrizia Diana

Convenient synthesis of pyrrolo[3,4-g]indazole

Virginia Spano', Paola Barraja, Patrizia Diana, Anna Carbone, Alessandra Montalbano, Barbara Parrino, Girolamo Cirrincione, Virginia Spanò, Barbara Parrino, Anna Carbone, Alessandra Montalbano, Paola Barraja, Girolamo Cirrincione, Patrizia Diana

Scienze e Tecnologie Biologiche Chimiche e Farmaceutiche

Risultato della ricerca: Article › peer review

15 Citazioni (Scopus)

Abstract

The synthesis of a novel class of tetrahydropyrrolo[3,4-g]indazoles is reported, by annelation of thepyrazole ring on the isoindole moiety by means of 5-hydroxymethylene tetrahydroisoindole-4-ones keyintermediates, with good regioselectivity. Dihydroderivatives were also obtained by oxidation with DDQof the corresponding tetrahydropyrrolo[3,4-g]indazoles. The growth inhibitory effect was evaluated atthe National Cancer Institute of Bethesda and some derivatives showed modest activity.

Lingua originale	English
pagine (da-a)	9839-9847
Numero di pagine	9
Rivista	Tetrahedron
Volume	69
Stato di pubblicazione	Published - 2013

All Science Journal Classification (ASJC) codes

Biochemistry
Drug Discovery
Organic Chemistry

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Convenient synthesis of pyrrolo[3,4-g]indazole. / Spano', Virginia ; Barraja, Paola ; Diana, Patrizia ; Carbone, Anna ; Montalbano, Alessandra ; Parrino, Barbara ; Cirrincione, Girolamo; Spanò, Virginia; Parrino, Barbara; Carbone, Anna; Montalbano, Alessandra; Barraja, Paola; Cirrincione, Girolamo; Diana, Patrizia.

In: Tetrahedron, Vol. 69, 2013, pag. 9839-9847.

Risultato della ricerca: Article › peer review

Spano', Virginia ; Barraja, Paola ; Diana, Patrizia ; Carbone, Anna ; Montalbano, Alessandra ; Parrino, Barbara ; Cirrincione, Girolamo ; Spanò, Virginia ; Parrino, Barbara ; Carbone, Anna ; Montalbano, Alessandra ; Barraja, Paola ; Cirrincione, Girolamo ; Diana, Patrizia. / Convenient synthesis of pyrrolo[3,4-g]indazole. In: Tetrahedron. 2013 ; Vol. 69. pagg. 9839-9847.

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abstract = "The synthesis of a novel class of tetrahydropyrrolo[3,4-g]indazoles is reported, by annelation of thepyrazole ring on the isoindole moiety by means of 5-hydroxymethylene tetrahydroisoindole-4-ones keyintermediates, with good regioselectivity. Dihydroderivatives were also obtained by oxidation with DDQof the corresponding tetrahydropyrrolo[3,4-g]indazoles. The growth inhibitory effect was evaluated atthe National Cancer Institute of Bethesda and some derivatives showed modest activity.",

keywords = "4-g]indazole, Antiproliferative activity, Hydroxymethyleneketones, Regioselectivity, Tetrahydropyrrolo[3, 4-g]indazole, Antiproliferative activity, Hydroxymethyleneketones, Regioselectivity, Tetrahydropyrrolo[3",

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AU - Spano', Virginia

AU - Barraja, Paola

AU - Diana, Patrizia

AU - Carbone, Anna

AU - Montalbano, Alessandra

AU - Parrino, Barbara

AU - Cirrincione, Girolamo

AU - Spanò, Virginia

AU - Parrino, Barbara

AU - Carbone, Anna

AU - Montalbano, Alessandra

AU - Barraja, Paola

AU - Cirrincione, Girolamo

AU - Diana, Patrizia

PY - 2013

Y1 - 2013

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AB - The synthesis of a novel class of tetrahydropyrrolo[3,4-g]indazoles is reported, by annelation of thepyrazole ring on the isoindole moiety by means of 5-hydroxymethylene tetrahydroisoindole-4-ones keyintermediates, with good regioselectivity. Dihydroderivatives were also obtained by oxidation with DDQof the corresponding tetrahydropyrrolo[3,4-g]indazoles. The growth inhibitory effect was evaluated atthe National Cancer Institute of Bethesda and some derivatives showed modest activity.

KW - 4-g]indazole

KW - Antiproliferative activity

KW - Hydroxymethyleneketones

KW - Regioselectivity

KW - Tetrahydropyrrolo[3

KW - 4-g]indazole

KW - Antiproliferative activity

KW - Hydroxymethyleneketones

KW - Regioselectivity

KW - Tetrahydropyrrolo[3

UR - http://hdl.handle.net/10447/83483

M3 - Article

VL - 69

SP - 9839

EP - 9847

JO - Tetrahedron

JF - Tetrahedron

SN - 0040-4020

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