Controversial roles of methylenetetrahydrofolate reductasepolymorphisms and folate in breast cancer disease

Valentina Bravata', Valentina Bravatà

    Risultato della ricerca: Articlepeer review

    9 Citazioni (Scopus)

    Abstract

    Breast cancer (BC) represents a highly heterogeneous tumour at both the clinical and molecularlevels. Single-nucleotide polymorphisms (SNPs) of the folate-metabolising enzyme methylenetetrahydrofolate-reductase (MTHFR) may modify the association between folate intake and BCand influence plasma folate concentration. The role of folate in BC is equivocal, associationstudies between the common MTHFR SNPs C677T and A1298C and BC risk are controversial. Inthis study, I have reviewed observed associations between folate intake, as well as its bloodlevels, and BC. The purpose of this review is to analyse the role of folate and the two SNPsassociated with reduced enzyme activity in BC. I explored the most relevant and updated workthat emphasises positive and negative associations among these variables. My findings indicatethat no definitive conclusions can be drawn from the studies on this topic. However, thismanuscript highlights variables that could be useful to explore in further association analyses
    Lingua originaleEnglish
    Numero di pagine7
    RivistaInternational Journal of Food Sciences and Nutrition
    VolumeIN PRESS
    Stato di pubblicazionePublished - 2014

    All Science Journal Classification (ASJC) codes

    • ???subjectarea.asjc.1100.1106???

    Fingerprint

    Entra nei temi di ricerca di 'Controversial roles of methylenetetrahydrofolate reductasepolymorphisms and folate in breast cancer disease'. Insieme formano una fingerprint unica.

    Cita questo