Contribution of proteomics to understanding the role oftumor-derived exosomes in cancer progression: State ofthe art and new perspectives

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62 Citazioni (Scopus)

Abstract

Exosomes are nanometer-sized vesicles (40–100 nm diameter) of endocytic origin releasedfrom different cell types under both normal and pathological conditions. They function as cellfree messengers, playing a relevant role in the cell–cell communication that is strongly relatedto the nature of the molecules (proteins, mRNAs, miRNAs, and lipids) that they transport.Tumor cells actively shed exosomes into their surrounding microenvironment and growingevidence indicates that these vesicles have pleiotropic functions in the regulation of tumorprogression, promoting immune escape, tumor invasion, neovascularization, and metastasis.During the last few years remarkable efforts have been made to obtain an accurate definitionof the protein content of tumor-derived exosomes (TDEs) by applying MS-based proteomictechnologies. To date, TDEs proteomic studies have been mainly utilized to catalog TDEsproteins with the purpose of identifying disease biomarkers. The future challenge for improvingour understanding and characterization of TDEs will be the implementation of new systemsdrivenand proteomic integrative strategies. The aim of this article is to provide an overview ofthe most characterized exosomes-mediated mechanisms that contribute to the pathogenesis ofcancer and to review recent proteomics data that support the protumorigenic role of TDEs.
Lingua originaleEnglish
pagine (da-a)1581-1594
Numero di pagine14
RivistaProteomics
Volume2013 Feb 11
Stato di pubblicazionePublished - 2013

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Biology

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