Consensus statements on vaccination in patients with haemophilia-Results from the Italian haemophilia and vaccinations (HEVA) project

Sergio Siragusa, Mariasanta Napolitano, Massimo Morfini, Erminia Baldacci, Grazia Delios, Leonardo Di Gennaro, Gianluca Sottilotta, Gaetano Giuffrida, Maria Cristina Vedovati, Gabriele Quintavalle, Chiara Biasoli, Giuseppe Lassandro, Raniero Malizia, Renata Ilde Mazzucchelli, Samantha Pasca, Mario Clerici, Marta Bertamino, Lucia Dora Notarangelo, Davide Matino, Paola PedrazziSimona Raso, Marta Milan, Mariasanta Napolitano, Antonio Coppola, Maria Basso, Johanna Svahn, Lucia Sarolo, Sergio Mario Siragusa, Dorina Cultrera, Anna Brigida Aru, Maria Luisa Serino, Cosimo Pietro Ettorre, Renato Marino, Giovanni Barillari, Elisa Bertoni, Patrizia Sciancalepore, Isabella Cantori, Matteo Di Minno, Angelo Claudio Molinari, Antonella Coluccia, Simona Bulgarelli, Sayla Bernasconi, Giovanni Gallo, Susanna Esposito, Michela Massoud, Massimo Galli, Elisa Bonetti, Silvia Macchi, Ezio Zanon, Eugenia Federica Biguzzi, Maria Cristina Vedovati, Paola Preti, Flora A. Peyvandi, Paola Preti, Giuseppe Malcangi, Mariasanta Napolitano, Chiara Ambaglio, Alessandra Borchiellini, Michele Schiavulli, Berardino Pollio, Erica De Candia, Piergiorgio Iannaccaro, Ugo Coppetelli, Silvia Linari, Lelia Valdrè, Paolo Radossi, Rosamaria Mura, Lydia Piscitelli, Alfredo Dragani, Angiola Rocino, Maria Gabriella Mazzucconi, Mario Schiavoni, Elena Santagostino, Patrizia Di Gregorio, Paolo Castiglia, Cristina Santoro, Marco Marietta, Annarita Tagliaferri, Giancarlo Castaman, Giovanni Di Minno, Simone Cesaro, Matteo Luciani, Agostino Riva, Paola Giordano, Rita Carlotta Santoro, Antonio Coppola, Massimo Franchini, Ilaria Lazzareschi, Irene Ricca, Sergio Cabibbo

Risultato della ricerca: Articlepeer review

5 Citazioni (Scopus)

Abstract

Vaccination against communicable diseases is crucial for disease prevention, but this practice poses challenges to healthcare professionals in patients with haemophilia. Poor knowledge of the vaccination requirements for these patients and safety concerns often result in vaccination delay or avoidance. In order to address this issue, a panel of 11 Italian haemophilia and immunization experts conducted a Delphi consensus process to identify the main concerns regarding the safe use of vaccines in patients with haemophilia. The consensus was based on a literature search of the available evidence, which was used by the experts to design 27 consensus statements. A group of clinicians then rated these statements using the 5-point Likert-type scale (1 = strongly disagree; 5 = strongly agree). The main issues identified by the expert panel included vaccination schedule for haemophilic patients; protocol and optimal route of vaccine administration; vaccination of haemophilic patients with antibodies inhibiting coagulation factor VIII (inhibitors); and vaccination and risk of inhibitor development. This manuscript discusses these controversial areas in detail supported by the available literature evidence and provides evidence- and consensus-based recommendations. Overall, participants agreed on most statements, except those addressing the potential role of vaccination in inhibitor formation. Participants agreed that patients with haemophilia should receive vaccinations according to the institutional schedule for individuals without bleeding disorders; however, vaccination of patients with haemophilia requires comprehensive planning, taking into account disease severity, type and route of vaccination, and bleeding risk. Data also suggest vaccination timing does not need to take into consideration when the patient received factor VIII replacement.
Lingua originaleEnglish
Numero di pagine11
RivistaHaemophilia
Stato di pubblicazionePublished - 2019

All Science Journal Classification (ASJC) codes

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