Congenital cytomegalovirus related intestinal malrotation: a case report

Giovanni Corsello, Mario Giuffre, Claudia Colomba, Simona De Grazia, Marcello Trizzino, Antonio Cascio, Simona De Grazia, Simona La Placa, Antonio Cascio, Marcello Trizzino, Giovanni Corsello, Claudia Colomba

Risultato della ricerca: Article

4 Citazioni (Scopus)

Abstract

Background: Cytomegalovirus is the most common cause of congenital infection in the developed countries. Gastrointestinal involvement has been extensively described in both adult and paediatric immunocompromised patients but it is infrequent in congenital or perinatal CMV infection. Case presentation: We report on a case of coexistent congenital Cytomegalovirus infection with intestinal malrotation and positive intestinal Cytomegalovirus biopsy. At birth the neonate showed clinical and radiological evidence of intestinal obstruction. Meconium passed only after evacuative nursing procedures; stooling pattern was irregular; gastric residuals were bile-stained. Laparatomy revealed a complete intestinal malrotation and contextually gastrointestinal biopsy samples of the appendix confirmed the diagnosis of CMV gastrointestinal disease. Intravenous ganciclovir was initiated for 2 weeks, followed by oral valgancyclovir for 6 month. Conclusion: CMV-induced proinflammatory process may be responsible of the interruption of the normal development of the gut or could in turn lead to a disruption in the normal development of the gut potentiating the mechanism causing malrotation. We suggest the hypothesis that an inflammatory process induced by CMV congenital infection may be responsible, in the early gestation, of the intestinal end-organ disease, as the intestinal malrotation. CMV infection should always be excluded in full-term infants presenting with colonic stricture or malrotation.
Lingua originaleEnglish
pagine (da-a)1-3
Numero di pagine3
RivistaTHE ITALIAN JOURNAL OF PEDIATRICS
Volume42
Stato di pubblicazionePublished - 2016

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Cytomegalovirus
Infection
Biopsy
Intestinal Diseases
Meconium
Ganciclovir
Gastrointestinal Diseases
Intestinal Obstruction
Cytomegalovirus Infections
Immunocompromised Host
Developed Countries
Bile
Stomach
Pathologic Constriction
Nursing
Parturition
Newborn Infant
Pediatrics
Pregnancy

All Science Journal Classification (ASJC) codes

  • Pediatrics, Perinatology, and Child Health

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Congenital cytomegalovirus related intestinal malrotation: a case report. / Corsello, Giovanni; Giuffre, Mario; Colomba, Claudia; De Grazia, Simona; Trizzino, Marcello; Cascio, Antonio; De Grazia, Simona; La Placa, Simona; Cascio, Antonio; Trizzino, Marcello; Corsello, Giovanni; Colomba, Claudia.

In: THE ITALIAN JOURNAL OF PEDIATRICS, Vol. 42, 2016, pag. 1-3.

Risultato della ricerca: Article

Corsello, Giovanni ; Giuffre, Mario ; Colomba, Claudia ; De Grazia, Simona ; Trizzino, Marcello ; Cascio, Antonio ; De Grazia, Simona ; La Placa, Simona ; Cascio, Antonio ; Trizzino, Marcello ; Corsello, Giovanni ; Colomba, Claudia. / Congenital cytomegalovirus related intestinal malrotation: a case report. In: THE ITALIAN JOURNAL OF PEDIATRICS. 2016 ; Vol. 42. pagg. 1-3.
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title = "Congenital cytomegalovirus related intestinal malrotation: a case report",
abstract = "Background: Cytomegalovirus is the most common cause of congenital infection in the developed countries. Gastrointestinal involvement has been extensively described in both adult and paediatric immunocompromised patients but it is infrequent in congenital or perinatal CMV infection. Case presentation: We report on a case of coexistent congenital Cytomegalovirus infection with intestinal malrotation and positive intestinal Cytomegalovirus biopsy. At birth the neonate showed clinical and radiological evidence of intestinal obstruction. Meconium passed only after evacuative nursing procedures; stooling pattern was irregular; gastric residuals were bile-stained. Laparatomy revealed a complete intestinal malrotation and contextually gastrointestinal biopsy samples of the appendix confirmed the diagnosis of CMV gastrointestinal disease. Intravenous ganciclovir was initiated for 2 weeks, followed by oral valgancyclovir for 6 month. Conclusion: CMV-induced proinflammatory process may be responsible of the interruption of the normal development of the gut or could in turn lead to a disruption in the normal development of the gut potentiating the mechanism causing malrotation. We suggest the hypothesis that an inflammatory process induced by CMV congenital infection may be responsible, in the early gestation, of the intestinal end-organ disease, as the intestinal malrotation. CMV infection should always be excluded in full-term infants presenting with colonic stricture or malrotation.",
author = "Giovanni Corsello and Mario Giuffre and Claudia Colomba and {De Grazia}, Simona and Marcello Trizzino and Antonio Cascio and {De Grazia}, Simona and {La Placa}, Simona and Antonio Cascio and Marcello Trizzino and Giovanni Corsello and Claudia Colomba",
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T1 - Congenital cytomegalovirus related intestinal malrotation: a case report

AU - Corsello, Giovanni

AU - Giuffre, Mario

AU - Colomba, Claudia

AU - De Grazia, Simona

AU - Trizzino, Marcello

AU - Cascio, Antonio

AU - De Grazia, Simona

AU - La Placa, Simona

AU - Cascio, Antonio

AU - Trizzino, Marcello

AU - Corsello, Giovanni

AU - Colomba, Claudia

PY - 2016

Y1 - 2016

N2 - Background: Cytomegalovirus is the most common cause of congenital infection in the developed countries. Gastrointestinal involvement has been extensively described in both adult and paediatric immunocompromised patients but it is infrequent in congenital or perinatal CMV infection. Case presentation: We report on a case of coexistent congenital Cytomegalovirus infection with intestinal malrotation and positive intestinal Cytomegalovirus biopsy. At birth the neonate showed clinical and radiological evidence of intestinal obstruction. Meconium passed only after evacuative nursing procedures; stooling pattern was irregular; gastric residuals were bile-stained. Laparatomy revealed a complete intestinal malrotation and contextually gastrointestinal biopsy samples of the appendix confirmed the diagnosis of CMV gastrointestinal disease. Intravenous ganciclovir was initiated for 2 weeks, followed by oral valgancyclovir for 6 month. Conclusion: CMV-induced proinflammatory process may be responsible of the interruption of the normal development of the gut or could in turn lead to a disruption in the normal development of the gut potentiating the mechanism causing malrotation. We suggest the hypothesis that an inflammatory process induced by CMV congenital infection may be responsible, in the early gestation, of the intestinal end-organ disease, as the intestinal malrotation. CMV infection should always be excluded in full-term infants presenting with colonic stricture or malrotation.

AB - Background: Cytomegalovirus is the most common cause of congenital infection in the developed countries. Gastrointestinal involvement has been extensively described in both adult and paediatric immunocompromised patients but it is infrequent in congenital or perinatal CMV infection. Case presentation: We report on a case of coexistent congenital Cytomegalovirus infection with intestinal malrotation and positive intestinal Cytomegalovirus biopsy. At birth the neonate showed clinical and radiological evidence of intestinal obstruction. Meconium passed only after evacuative nursing procedures; stooling pattern was irregular; gastric residuals were bile-stained. Laparatomy revealed a complete intestinal malrotation and contextually gastrointestinal biopsy samples of the appendix confirmed the diagnosis of CMV gastrointestinal disease. Intravenous ganciclovir was initiated for 2 weeks, followed by oral valgancyclovir for 6 month. Conclusion: CMV-induced proinflammatory process may be responsible of the interruption of the normal development of the gut or could in turn lead to a disruption in the normal development of the gut potentiating the mechanism causing malrotation. We suggest the hypothesis that an inflammatory process induced by CMV congenital infection may be responsible, in the early gestation, of the intestinal end-organ disease, as the intestinal malrotation. CMV infection should always be excluded in full-term infants presenting with colonic stricture or malrotation.

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