Confinement stress in sea bass (Dicentrarchus labrax) depresses peritoneal leukocyte cytotoxicity

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105 Citazioni (Scopus)


Fish respond to stressful conditions via neuroendocrine responses (primary response) which result in increased levels of plasma cortisol which is considered immunosuppressive. Sea bass were confined at low (10 kg/m3) and high (60 kg/m3) density for 3-48 h. Plasma cortisol and glucose were evaluated and two principal cellular immune responses were assayed. A significant increase in plasma cortisol and glucose levels, as well as osmolarity, was found following stress. In addition, phagocytic activity, as shown by reactive oxygen species (ROS) production by challenged head kidney phagocytes and cytotoxic activity of eosinophilic granule cells from peritoneal cavity against K562 tumour cell lines appeared to be suppressed. Plasma levels of cortisol, glucose, osmolarity were correlated with cellular immunity, by the linear regression method. The suppression of cytotoxic activity was found to be significantly correlated with high plasma cortisol and glucose levels. These parameters could affect the eosinophilic granule cells of the peritoneal cavity.
Lingua originaleEnglish
pagine (da-a)231-243
Numero di pagine13
Stato di pubblicazionePublished - 2002

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