Abstract
| Lingua originale | English |
|---|---|
| Numero di pagine | 0 |
| Rivista | Default journal |
| Volume | 2014 |
| Stato di pubblicazione | Published - 2014 |
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Concomitant Small Cell Neuroendocrine Carcinoma ofGallbladder and Breast Cancer. / Di Vita, Gaetano Giuseppe; Caruso, Anna Maria; Buscemi, Salvatore; Aragona, Francesco; Patti, Rosalia; Territo, Valentina.
In: Default journal, Vol. 2014, 2014.Risultato della ricerca: Article
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TY - JOUR
T1 - Concomitant Small Cell Neuroendocrine Carcinoma ofGallbladder and Breast Cancer
AU - Di Vita, Gaetano Giuseppe
AU - Caruso, Anna Maria
AU - Buscemi, Salvatore
AU - Aragona, Francesco
AU - Patti, Rosalia
AU - Territo, Valentina
PY - 2014
Y1 - 2014
N2 - The neuroendocrine carcinoma is defined as a high-grade malignant neuroendocrine neoplasm arising from enterochromaffincells, usually disposed in the mucosa of gastric and respiratory tracts. The localization in the gallbladder is rare. Knowledge ofthese gallbladder tumors is limited and based on isolated case reports. We describe a case of an incidental finding of small cellneuroendocrine carcinoma of the gallbladder, observed after cholecystectomy for cholelithiasis, in a 55-year-old female, whoalready underwent quadrantectomy and sentinel lymph-node biopsy for breast cancer. The patient underwent radiotherapy forbreast cancer and six cycles of chemotherapy with cisplatin and etoposide. Eighteen months after surgery, the patient was free fromdisease. Small cell neuroendocrine carcinoma of the gallbladder has poor prognosis. Because of the rarity of the reported cases,specific prognostic factors have not been identified. The coexistence of small cell neuroendocrine carcinoma of the gallbladderwith another malignancy has been reported only once.The contemporary presence of the two neoplasms could reflect that bioactiveagents secreted by carcinoid can promote phenotypic changes in susceptible cells and induce neoplastic transformation.
AB - The neuroendocrine carcinoma is defined as a high-grade malignant neuroendocrine neoplasm arising from enterochromaffincells, usually disposed in the mucosa of gastric and respiratory tracts. The localization in the gallbladder is rare. Knowledge ofthese gallbladder tumors is limited and based on isolated case reports. We describe a case of an incidental finding of small cellneuroendocrine carcinoma of the gallbladder, observed after cholecystectomy for cholelithiasis, in a 55-year-old female, whoalready underwent quadrantectomy and sentinel lymph-node biopsy for breast cancer. The patient underwent radiotherapy forbreast cancer and six cycles of chemotherapy with cisplatin and etoposide. Eighteen months after surgery, the patient was free fromdisease. Small cell neuroendocrine carcinoma of the gallbladder has poor prognosis. Because of the rarity of the reported cases,specific prognostic factors have not been identified. The coexistence of small cell neuroendocrine carcinoma of the gallbladderwith another malignancy has been reported only once.The contemporary presence of the two neoplasms could reflect that bioactiveagents secreted by carcinoid can promote phenotypic changes in susceptible cells and induce neoplastic transformation.
UR - http://hdl.handle.net/10447/98589
M3 - Article
VL - 2014
JO - Default journal
JF - Default journal
ER -