Concise asymmetric synthesis of Linezolid through catalyzed Henry reaction.

Andrea Pace; Antonio Palumbo Piccionello; Angela Accardo; Silvestre Buscemi; null Accardo; Andrea Pace; Paola Pierro; null Buscemi; A. Palumbo Piccionello; Paola Pierro

Concise asymmetric synthesis of Linezolid through catalyzed Henry reaction.

Andrea Pace, Antonio Palumbo Piccionello, Angela Accardo, Silvestre Buscemi, Accardo, Andrea Pace, Paola Pierro, Buscemi, A. Palumbo Piccionello, Paola Pierro

Scienze e Tecnologie Biologiche Chimiche e Farmaceutiche

Risultato della ricerca: Article › peer review

10 Citazioni (Scopus)

Abstract

A new asymmetric synthesis of the antibiotic Linezolid was performed through a copper-catalyzed Henryreaction as the key step. The use of camphor-derived aminopyridine ligands helped to improve the yields ofthe chiral precursor and to obtain Linezolid in good overall yield and enantiomeric excess.

Lingua originale	English
pagine (da-a)	24946-24951
Numero di pagine	6
Rivista	RSC Advances
Volume	3
Stato di pubblicazione	Published - 2013

All Science Journal Classification (ASJC) codes

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title = "Concise asymmetric synthesis of Linezolid through catalyzed Henry reaction.",

abstract = "A new asymmetric synthesis of the antibiotic Linezolid was performed through a copper-catalyzed Henryreaction as the key step. The use of camphor-derived aminopyridine ligands helped to improve the yields ofthe chiral precursor and to obtain Linezolid in good overall yield and enantiomeric excess.",

author = "Andrea Pace and {Palumbo Piccionello}, Antonio and Angela Accardo and Silvestre Buscemi and Accardo and Andrea Pace and Paola Pierro and Buscemi and Piccionello, {A. Palumbo} and Paola Pierro",

year = "2013",

language = "English",

volume = "3",

pages = "24946--24951",

journal = "RSC Advances",

issn = "2046-2069",

publisher = "Royal Society of Chemistry",

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TY - JOUR

T1 - Concise asymmetric synthesis of Linezolid through catalyzed Henry reaction.

AU - Pace, Andrea

AU - Palumbo Piccionello, Antonio

AU - Accardo, Angela

AU - Buscemi, Silvestre

AU - Accardo, null

AU - Pace, Andrea

AU - Pierro, Paola

AU - Buscemi, null

AU - Piccionello, A. Palumbo

AU - Pierro, Paola

PY - 2013

Y1 - 2013

N2 - A new asymmetric synthesis of the antibiotic Linezolid was performed through a copper-catalyzed Henryreaction as the key step. The use of camphor-derived aminopyridine ligands helped to improve the yields ofthe chiral precursor and to obtain Linezolid in good overall yield and enantiomeric excess.

AB - A new asymmetric synthesis of the antibiotic Linezolid was performed through a copper-catalyzed Henryreaction as the key step. The use of camphor-derived aminopyridine ligands helped to improve the yields ofthe chiral precursor and to obtain Linezolid in good overall yield and enantiomeric excess.

UR - http://hdl.handle.net/10447/88647

M3 - Article

VL - 3

SP - 24946

EP - 24951

JO - RSC Advances

JF - RSC Advances

SN - 2046-2069

ER -