Comprehensive Geriatric Assessment is an essential tool to support treatment decisions in elderly patients with Diffuse Large B Cell Lymphoma: A prospective multicenter evaluation on 173 patients by the Lymphoma Italian Foundation (FIL)

Salvatrice Mancuso, Benedetta Puccini, Chiara Bottelli, Francesco Bertagna, Paola Riccomagno, Maurizio Martelli, Germaine Cornelissen, Michele Spina, Daniela Dalceggio, Stefano Fogazzi, Junko Sasaki, Alessandra Tucci, Paolo Paesano, Gaku Yamanaka, Angelo Fama, Sachiko Oinuma, Caterina Stelitano, Luigi Rigacci, Sergio Storti, Maura BrugiatelliKiyohito Okumiya, Flavia Salvi, Alberto Fabbri, Kozo Matsubayashi, Salvatrice Mancuso, Kuniaki Otsuka, Giuseppe Rossi, Maria Giuseppina Cabras, Takashi Yamanaka

Risultato della ricerca: Articlepeer review

69 Citazioni (Scopus)

Abstract

We performed a multicenter study to validate the concept that a simple comprehensive geriatric assessment (CGA) can identify elderly, non-fit patients with diffuse large B-cell lymphoma (DLBCL) in whom curative treatment is not better then palliation, and to analyze potential benefits of treatment modulation after further subdividing the non-fit category by CGA criteria. One hundred and seventy-three patients aged > 69 treated with curative or palliative intent by clinical judgement only were grouped according to CGA into fit (46%), unfit (16%) and frail (38%) categories. Two-year overall survival (OS) was significantly better in fit than in non-fit patients (84% vs. 47%; p < 0.0001). Survival in unfit and frail patients was not significantly different. Curative treatment slightly improved 2-year OS in unfit (75% vs. 45%) but not in frail patients (44% vs. 39%). CGA was confirmed as very efficient in identifying elderly patients with DLBCL who can benefit from a curative approach. Further efforts are needed to better tailor therapies in non-fit patients.
Lingua originaleEnglish
pagine (da-a)921-926
Numero di pagine6
RivistaLEUKEMIA & LYMPHOMA
Volume56
Stato di pubblicazionePublished - 2015

All Science Journal Classification (ASJC) codes

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  • ???subjectarea.asjc.2700.2730???
  • ???subjectarea.asjc.1300.1306???
  • ???subjectarea.asjc.2700.2717???

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