“Comparison of the safety and efficacy of paclitaxel plus gemcitabine combination in young and elderly patients with locally advanced or metastatic non-small cell lung cancer. A retrospective analysis of the Southern Italy Cooperative Oncology Group trials”.

Sergio Palmeri, Carlo Putzu, Comella, Domenico Muci, Filippelli, Enrico Barbato, Ghiani, Condemi, Mereu, Olivito, Dima, Bianco, Gambardella, Mariotti, Messina, Iannelli, Valerio Milia, Carnicelli, Musicò, MancarellaBilancia, Maiorino, Maria Teresa Ionta, De Cataldis, Masullo, Di Lullo, Bruno Massidda, Salvatore Del Prete, Antonio Avallone, Roger Stupp, Buzzi, Cioffi, Bartolucci, Farris, Panza, Raffaele Costanzo, Giuseppe Frasci, Mario Roselli, Giorgio V. Scagliotti, Cesare Gridelli, Paccagnella, Michele Guida, Filomena Del Gaizo, Donato Natale

Risultato della ricerca: Article

7 Citazioni (Scopus)

Abstract

We retrospectively assessed tolerability and efficacy of paclitaxel plus gemcitabine combination in 259 patients with locally advanced or metastatic non-small cell lung cancer (NSCLC) enrolled in three randomized SICOG trials according to their age (<or=70 or >70 years) at study entry. Apart from age, demographic and clinical characteristics were similar in the two groups. Response rate of paclitaxel plus gemcitabine was similar in younger and in elderly (36% versus 30%). Chemotherapy was well tolerated, but severe neutropenia (12% versus 7%), anaemia (6.6% versus 1.8%), and vomiting (5% versus 0) were more frequent in elderly patients. Both median progression-free survival (PFS, 5.5 months versus 4.2 months), and overall survival (OS, 11.1 months versus 9.1 months) resulted slightly prolonged for younger patients. However, only stage and performance status resulted independently affecting PFS and OS. In conclusion, paclitaxel plus gemcitabine were similarly tolerated and active in younger and elderly patients. This regimen should be considered an option for the management of fit elderly patients.
Lingua originaleEnglish
pagine (da-a)164-171
Numero di pagine8
RivistaCRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY
Volume65
Stato di pubblicazionePublished - 2008

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All Science Journal Classification (ASJC) codes

  • Geriatrics and Gerontology
  • Hematology
  • Oncology

Cita questo

Palmeri, S., Putzu, C., Comella, Muci, D., Filippelli, Barbato, E., Ghiani, Condemi, Mereu, Olivito, Dima, Bianco, Gambardella, Mariotti, Messina, Iannelli, Milia, V., Carnicelli, Musicò, ... Natale, D. (2008). “Comparison of the safety and efficacy of paclitaxel plus gemcitabine combination in young and elderly patients with locally advanced or metastatic non-small cell lung cancer. A retrospective analysis of the Southern Italy Cooperative Oncology Group trials”. CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY, 65, 164-171.