TY - JOUR
T1 - Comparison of essential oil components and in vitro anticancer activity in wild and cultivated Salvia verbenaca
AU - Bruno, Maurizio
AU - Canzoneri, Marisa
AU - Graziano, Adriana C.E.
AU - Rigano, Daniela
AU - Cardile, Venera
AU - Senatore, Felice
AU - Russo, Alessandra
AU - Formisano, Carmen
PY - 2015
Y1 - 2015
N2 - The objectives of our research were to study the chemical composition and the in vitro anticancer effect of the essential oil of Salvia verbenaca growing in natural sites in comparison with those of cultivated (Sc) plants. The oil from wild (Sw) S. verbenaca presented hexadecanoic acid (23.1%) as the main constituent, while the oil from Sc plants contained high quantities of hexahydrofarnesyl acetone (9.7%), scarce in the natural oil (0.7%). The growth-inhibitory and proapoptotic effects of the essential oils from Sw and Sc S. verbenaca were evaluated in the human melanoma cell line M14, testing cell vitality, cell membrane integrity, genomic DNA fragmentation and caspase-3 activity. Both the essential oils were able to inhibit the growth of the cancer cells examined inducing also apoptotic cell death, but the essential oil from cultivated samples exhibited the major effects.
AB - The objectives of our research were to study the chemical composition and the in vitro anticancer effect of the essential oil of Salvia verbenaca growing in natural sites in comparison with those of cultivated (Sc) plants. The oil from wild (Sw) S. verbenaca presented hexadecanoic acid (23.1%) as the main constituent, while the oil from Sc plants contained high quantities of hexahydrofarnesyl acetone (9.7%), scarce in the natural oil (0.7%). The growth-inhibitory and proapoptotic effects of the essential oils from Sw and Sc S. verbenaca were evaluated in the human melanoma cell line M14, testing cell vitality, cell membrane integrity, genomic DNA fragmentation and caspase-3 activity. Both the essential oils were able to inhibit the growth of the cancer cells examined inducing also apoptotic cell death, but the essential oil from cultivated samples exhibited the major effects.
KW - Phytogenic; Apoptosis; Caspase 3; Cell Line
KW - Tumor; DNA Fragmentation; Humans; Melanoma; Oils
KW - Volatile; Palmitic Acid; Plant Oils; Salvia; Terpenes; Analytical Chemistry; Biochemistry; Plant Science; Organic Chemistry
KW - apoptosis; essential oil; Lamiaceae; melanoma; Salvia verbenaca; sesquiterpenes; Antineoplastic Agents
KW - Phytogenic; Apoptosis; Caspase 3; Cell Line
KW - Tumor; DNA Fragmentation; Humans; Melanoma; Oils
KW - Volatile; Palmitic Acid; Plant Oils; Salvia; Terpenes; Analytical Chemistry; Biochemistry; Plant Science; Organic Chemistry
KW - apoptosis; essential oil; Lamiaceae; melanoma; Salvia verbenaca; sesquiterpenes; Antineoplastic Agents
UR - http://hdl.handle.net/10447/253273
UR - http://www.tandf.co.uk/journals/titles/14786419.asp
M3 - Article
SN - 1478-6419
VL - 29
SP - 1630
EP - 1640
JO - Natural Product Research
JF - Natural Product Research
ER -