Comparison of Different Nodal Staging in Patients With Locally Advanced Mid-low Rectal Cancer After Long-term Neoadjuvant Chemoradiation Therapy

Pietro Genova, Eloy Espin, Riccardo Memeo, Niccolò Petrucciani, Maria Clotilde Carra, Giulio Cesare Vitali, Filippo Landi, Aleix Martínez-Pérez, Pietro Genova, Nicola De’Angelis, Frederic Ris, Francesco Brunetti

Risultato della ricerca: Article

Abstract

Background/Aim: The aim of this study was to compare the ability of different lymph nodal staging systems to predict cancer recurrence in a multicenter European series of patients who underwent proctectomy after neoadjuvant chemoradiotherapy for locally advanced rectal cancer.Patients and Methods: Data on 170 consecutive patients undergoing proctectomy after neoadjuvant therapy for cT3-4 or cN+ rectal adenocarcinoma were retrieved from the European MRI and Rectal Cancer Surgery database. The prognostic role of the number of retrieved and examined nodes, nodal ratio, and log odds of positive lymph nodes (LODDS) was analyzed and compared by receiver operating characteristic curves, Pearson test, and univariate and multivariate analysis.Results: At multivariate analysis, ypN, nodal ratio, and LODDS were all significantly associated with disease-free survival, but LODDS showed the strongest association (hazard ratio(HR)=2.39; 95% confidence interval(CI)=1.05-5.48; p=0.039).Conclusion: LODDS appears to be a useful prognostic indicator in the prediction of disease-free survival of patients undergoing neoadjuvant chemoradiotherapy and proctectomy for locally advanced rectal cancer.
Lingua originaleEnglish
pagine (da-a)2113-2120
Numero di pagine8
RivistaAnticancer Research
Volume39
Stato di pubblicazionePublished - 2019

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Neoadjuvant Therapy
Rectal Neoplasms
Chemoradiotherapy
Disease-Free Survival
Multivariate Analysis
Lymph
ROC Curve
Adenocarcinoma
Lymph Nodes
Odds Ratio
Databases
Confidence Intervals
Recurrence
Neoplasms

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

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Comparison of Different Nodal Staging in Patients With Locally Advanced Mid-low Rectal Cancer After Long-term Neoadjuvant Chemoradiation Therapy. / Genova, Pietro; Espin, Eloy; Memeo, Riccardo; Petrucciani, Niccolò; Carra, Maria Clotilde; Vitali, Giulio Cesare; Landi, Filippo; Martínez-Pérez, Aleix; Genova, Pietro; De’Angelis, Nicola; Ris, Frederic; Brunetti, Francesco.

In: Anticancer Research, Vol. 39, 2019, pag. 2113-2120.

Risultato della ricerca: Article

Genova, P, Espin, E, Memeo, R, Petrucciani, N, Carra, MC, Vitali, GC, Landi, F, Martínez-Pérez, A, Genova, P, De’Angelis, N, Ris, F & Brunetti, F 2019, 'Comparison of Different Nodal Staging in Patients With Locally Advanced Mid-low Rectal Cancer After Long-term Neoadjuvant Chemoradiation Therapy', Anticancer Research, vol. 39, pagg. 2113-2120.
Genova, Pietro ; Espin, Eloy ; Memeo, Riccardo ; Petrucciani, Niccolò ; Carra, Maria Clotilde ; Vitali, Giulio Cesare ; Landi, Filippo ; Martínez-Pérez, Aleix ; Genova, Pietro ; De’Angelis, Nicola ; Ris, Frederic ; Brunetti, Francesco. / Comparison of Different Nodal Staging in Patients With Locally Advanced Mid-low Rectal Cancer After Long-term Neoadjuvant Chemoradiation Therapy. In: Anticancer Research. 2019 ; Vol. 39. pagg. 2113-2120.
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title = "Comparison of Different Nodal Staging in Patients With Locally Advanced Mid-low Rectal Cancer After Long-term Neoadjuvant Chemoradiation Therapy",
abstract = "Background/Aim: The aim of this study was to compare the ability of different lymph nodal staging systems to predict cancer recurrence in a multicenter European series of patients who underwent proctectomy after neoadjuvant chemoradiotherapy for locally advanced rectal cancer.Patients and Methods: Data on 170 consecutive patients undergoing proctectomy after neoadjuvant therapy for cT3-4 or cN+ rectal adenocarcinoma were retrieved from the European MRI and Rectal Cancer Surgery database. The prognostic role of the number of retrieved and examined nodes, nodal ratio, and log odds of positive lymph nodes (LODDS) was analyzed and compared by receiver operating characteristic curves, Pearson test, and univariate and multivariate analysis.Results: At multivariate analysis, ypN, nodal ratio, and LODDS were all significantly associated with disease-free survival, but LODDS showed the strongest association (hazard ratio(HR)=2.39; 95{\%} confidence interval(CI)=1.05-5.48; p=0.039).Conclusion: LODDS appears to be a useful prognostic indicator in the prediction of disease-free survival of patients undergoing neoadjuvant chemoradiotherapy and proctectomy for locally advanced rectal cancer.",
author = "Pietro Genova and Eloy Espin and Riccardo Memeo and Niccol{\`o} Petrucciani and Carra, {Maria Clotilde} and Vitali, {Giulio Cesare} and Filippo Landi and Aleix Mart{\'i}nez-P{\'e}rez and Pietro Genova and Nicola De’Angelis and Frederic Ris and Francesco Brunetti",
year = "2019",
language = "English",
volume = "39",
pages = "2113--2120",
journal = "Anticancer Research",
issn = "0250-7005",
publisher = "International Institute of Anticancer Research",

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TY - JOUR

T1 - Comparison of Different Nodal Staging in Patients With Locally Advanced Mid-low Rectal Cancer After Long-term Neoadjuvant Chemoradiation Therapy

AU - Genova, Pietro

AU - Espin, Eloy

AU - Memeo, Riccardo

AU - Petrucciani, Niccolò

AU - Carra, Maria Clotilde

AU - Vitali, Giulio Cesare

AU - Landi, Filippo

AU - Martínez-Pérez, Aleix

AU - Genova, Pietro

AU - De’Angelis, Nicola

AU - Ris, Frederic

AU - Brunetti, Francesco

PY - 2019

Y1 - 2019

N2 - Background/Aim: The aim of this study was to compare the ability of different lymph nodal staging systems to predict cancer recurrence in a multicenter European series of patients who underwent proctectomy after neoadjuvant chemoradiotherapy for locally advanced rectal cancer.Patients and Methods: Data on 170 consecutive patients undergoing proctectomy after neoadjuvant therapy for cT3-4 or cN+ rectal adenocarcinoma were retrieved from the European MRI and Rectal Cancer Surgery database. The prognostic role of the number of retrieved and examined nodes, nodal ratio, and log odds of positive lymph nodes (LODDS) was analyzed and compared by receiver operating characteristic curves, Pearson test, and univariate and multivariate analysis.Results: At multivariate analysis, ypN, nodal ratio, and LODDS were all significantly associated with disease-free survival, but LODDS showed the strongest association (hazard ratio(HR)=2.39; 95% confidence interval(CI)=1.05-5.48; p=0.039).Conclusion: LODDS appears to be a useful prognostic indicator in the prediction of disease-free survival of patients undergoing neoadjuvant chemoradiotherapy and proctectomy for locally advanced rectal cancer.

AB - Background/Aim: The aim of this study was to compare the ability of different lymph nodal staging systems to predict cancer recurrence in a multicenter European series of patients who underwent proctectomy after neoadjuvant chemoradiotherapy for locally advanced rectal cancer.Patients and Methods: Data on 170 consecutive patients undergoing proctectomy after neoadjuvant therapy for cT3-4 or cN+ rectal adenocarcinoma were retrieved from the European MRI and Rectal Cancer Surgery database. The prognostic role of the number of retrieved and examined nodes, nodal ratio, and log odds of positive lymph nodes (LODDS) was analyzed and compared by receiver operating characteristic curves, Pearson test, and univariate and multivariate analysis.Results: At multivariate analysis, ypN, nodal ratio, and LODDS were all significantly associated with disease-free survival, but LODDS showed the strongest association (hazard ratio(HR)=2.39; 95% confidence interval(CI)=1.05-5.48; p=0.039).Conclusion: LODDS appears to be a useful prognostic indicator in the prediction of disease-free survival of patients undergoing neoadjuvant chemoradiotherapy and proctectomy for locally advanced rectal cancer.

UR - http://hdl.handle.net/10447/368168

M3 - Article

VL - 39

SP - 2113

EP - 2120

JO - Anticancer Research

JF - Anticancer Research

SN - 0250-7005

ER -