1 Citazione (Scopus)

Abstract

The drugs available for inflammatory bowel disease are aminosalicylates, antibiotics, steroids, immunosuppressors and biologics. The effectiveness of these drugs has been evaluated in many randomized clinical trials, mainly versus placebo. Few studies have been conducted comparing the different drugs among themselves, owing to the methodological problems raised by comparative trials, such as sample size and blindness. This review focuses mainly on the randomized clinical trials that have compared different treatments. Of course comparisons are mainly between drugs used in a particular setting (mild, moderate and severe disease). However, on many occasions there is no homogeneity in these clinical settings, and therefore the results are difficult to interpret
Lingua originaleEnglish
pagine (da-a)135-149
Numero di pagine15
RivistaJournal of Comparative Effectiveness Research
Volume2
Stato di pubblicazionePublished - 2013

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Crohn Disease
Pharmaceutical Preparations
Randomized Controlled Trials
Blindness
Therapeutics
Biological Products
Inflammatory Bowel Diseases
Sample Size
Steroids
Placebos
Anti-Bacterial Agents

All Science Journal Classification (ASJC) codes

  • Health Policy

Cita questo

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title = "Comparing medical treatment in Crohn's disease",
abstract = "The drugs available for inflammatory bowel disease are aminosalicylates, antibiotics, steroids, immunosuppressors and biologics. The effectiveness of these drugs has been evaluated in many randomized clinical trials, mainly versus placebo. Few studies have been conducted comparing the different drugs among themselves, owing to the methodological problems raised by comparative trials, such as sample size and blindness. This review focuses mainly on the randomized clinical trials that have compared different treatments. Of course comparisons are mainly between drugs used in a particular setting (mild, moderate and severe disease). However, on many occasions there is no homogeneity in these clinical settings, and therefore the results are difficult to interpret",
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