Abstract
| Lingua originale | English |
|---|---|
| pagine (da-a) | 4759-4766 |
| Numero di pagine | 8 |
| Rivista | Default journal |
| Volume | 37 |
| Stato di pubblicazione | Published - 2017 |
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All Science Journal Classification (ASJC) codes
- Oncology
- Cancer Research
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COLORECTAL CARCINOGENESIS; ROLE OF OXIDATIVE STRESS AND ANTIOXIDANTS. / Rappa, Francesca; Leone, Angelo; Carini, Francesco; Tomasello, Giovanni; Jurjus, Rosalyn; Bou-Assi, Tarek; Geagea, Alice Gerges; Al Kattar, Sahar; Mazzola, Margherita; Jurjus, Abdo.
In: Default journal, Vol. 37, 2017, pag. 4759-4766.Risultato della ricerca: Article
}
TY - JOUR
T1 - COLORECTAL CARCINOGENESIS; ROLE OF OXIDATIVE STRESS AND ANTIOXIDANTS
AU - Rappa, Francesca
AU - Leone, Angelo
AU - Carini, Francesco
AU - Tomasello, Giovanni
AU - Jurjus, Rosalyn
AU - Bou-Assi, Tarek
AU - Geagea, Alice Gerges
AU - Al Kattar, Sahar
AU - Mazzola, Margherita
AU - Jurjus, Abdo
PY - 2017
Y1 - 2017
N2 - One of the contributory causes of colon cancer is the negative effect of reactive oxygen species on DNA repair mechanism. Currently, there is a growing support for the concept that oxidative stress may be an important etiological factor for carcinogenesis. The purpose of this review is to elucidate the role of oxidative stress in promoting colorectal carcinogenesis and to highlight the potential protective role of antioxidants. Several studies have documentes the importance of antioxidants in countering oxidative stress and preventing colorectal carcinogenesis. However, there are conflicting data in the literature concerning its proper use in humans, since these studies did not yeld definitive results and were performed mostly in vitro on cell population, or in vivo in experimental animal models.
AB - One of the contributory causes of colon cancer is the negative effect of reactive oxygen species on DNA repair mechanism. Currently, there is a growing support for the concept that oxidative stress may be an important etiological factor for carcinogenesis. The purpose of this review is to elucidate the role of oxidative stress in promoting colorectal carcinogenesis and to highlight the potential protective role of antioxidants. Several studies have documentes the importance of antioxidants in countering oxidative stress and preventing colorectal carcinogenesis. However, there are conflicting data in the literature concerning its proper use in humans, since these studies did not yeld definitive results and were performed mostly in vitro on cell population, or in vivo in experimental animal models.
KW - Animals
KW - Antioxidants
KW - Cancer Research
KW - Carcinogenesis
KW - Colorectal Neoplasms
KW - Colorectal cancer
KW - Dysbiosis
KW - Humans
KW - Oncology
KW - Oxidative Stress
KW - Oxidative stress
KW - Reactive Oxygen Species
KW - Review
UR - http://hdl.handle.net/10447/242104
UR - http://ar.iiarjournals.org/content/37/9/4759.full.pdf
M3 - Article
VL - 37
SP - 4759
EP - 4766
JO - Default journal
JF - Default journal
ER -