COLORECTAL CARCINOGENESIS; ROLE OF OXIDATIVE STRESS AND ANTIOXIDANTS

Francesca Rappa; Angelo Leone; Francesco Carini; Giovanni Tomasello; Rosalyn Jurjus; Tarek Bou-Assi; Alice Gerges Geagea; Sahar Al Kattar; Margherita Mazzola; Abdo Jurjus

COLORECTAL CARCINOGENESIS; ROLE OF OXIDATIVE STRESS AND ANTIOXIDANTS

Francesca Rappa, Angelo Leone, Francesco Carini, Giovanni Tomasello, Rosalyn Jurjus, Tarek Bou-Assi, Alice Gerges Geagea, Sahar Al Kattar, Margherita Mazzola, Abdo Jurjus

Risultato della ricerca: Article

30 Citazioni (Scopus)

Abstract

One of the contributory causes of colon cancer is the negative effect of reactive oxygen species on DNA repair mechanism. Currently, there is a growing support for the concept that oxidative stress may be an important etiological factor for carcinogenesis. The purpose of this review is to elucidate the role of oxidative stress in promoting colorectal carcinogenesis and to highlight the potential protective role of antioxidants. Several studies have documentes the importance of antioxidants in countering oxidative stress and preventing colorectal carcinogenesis. However, there are conflicting data in the literature concerning its proper use in humans, since these studies did not yeld definitive results and were performed mostly in vitro on cell population, or in vivo in experimental animal models.

Lingua originale	English
pagine (da-a)	4759-4766
Numero di pagine	8
Rivista	Anticancer Research
Volume	37
Stato di pubblicazione	Published - 2017

All Science Journal Classification (ASJC) codes

Oncology
Cancer Research

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Rappa, F., Leone, A., Carini, F., Tomasello, G., Jurjus, R., Bou-Assi, T., Geagea, A. G., Al Kattar, S., Mazzola, M., & Jurjus, A. (2017). COLORECTAL CARCINOGENESIS; ROLE OF OXIDATIVE STRESS AND ANTIOXIDANTS. Anticancer Research, 37, 4759-4766.

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title = "COLORECTAL CARCINOGENESIS; ROLE OF OXIDATIVE STRESS AND ANTIOXIDANTS",

abstract = "One of the contributory causes of colon cancer is the negative effect of reactive oxygen species on DNA repair mechanism. Currently, there is a growing support for the concept that oxidative stress may be an important etiological factor for carcinogenesis. The purpose of this review is to elucidate the role of oxidative stress in promoting colorectal carcinogenesis and to highlight the potential protective role of antioxidants. Several studies have documentes the importance of antioxidants in countering oxidative stress and preventing colorectal carcinogenesis. However, there are conflicting data in the literature concerning its proper use in humans, since these studies did not yeld definitive results and were performed mostly in vitro on cell population, or in vivo in experimental animal models.",

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author = "Francesca Rappa and Angelo Leone and Francesco Carini and Giovanni Tomasello and Rosalyn Jurjus and Tarek Bou-Assi and Geagea, {Alice Gerges} and {Al Kattar}, Sahar and Margherita Mazzola and Abdo Jurjus",

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language = "English",

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T1 - COLORECTAL CARCINOGENESIS; ROLE OF OXIDATIVE STRESS AND ANTIOXIDANTS

AU - Rappa, Francesca

AU - Leone, Angelo

AU - Carini, Francesco

AU - Tomasello, Giovanni

AU - Jurjus, Rosalyn

AU - Bou-Assi, Tarek

AU - Geagea, Alice Gerges

AU - Al Kattar, Sahar

AU - Mazzola, Margherita

AU - Jurjus, Abdo

PY - 2017

Y1 - 2017

N2 - One of the contributory causes of colon cancer is the negative effect of reactive oxygen species on DNA repair mechanism. Currently, there is a growing support for the concept that oxidative stress may be an important etiological factor for carcinogenesis. The purpose of this review is to elucidate the role of oxidative stress in promoting colorectal carcinogenesis and to highlight the potential protective role of antioxidants. Several studies have documentes the importance of antioxidants in countering oxidative stress and preventing colorectal carcinogenesis. However, there are conflicting data in the literature concerning its proper use in humans, since these studies did not yeld definitive results and were performed mostly in vitro on cell population, or in vivo in experimental animal models.

AB - One of the contributory causes of colon cancer is the negative effect of reactive oxygen species on DNA repair mechanism. Currently, there is a growing support for the concept that oxidative stress may be an important etiological factor for carcinogenesis. The purpose of this review is to elucidate the role of oxidative stress in promoting colorectal carcinogenesis and to highlight the potential protective role of antioxidants. Several studies have documentes the importance of antioxidants in countering oxidative stress and preventing colorectal carcinogenesis. However, there are conflicting data in the literature concerning its proper use in humans, since these studies did not yeld definitive results and were performed mostly in vitro on cell population, or in vivo in experimental animal models.

KW - Animals

KW - Antioxidants

KW - Cancer Research

KW - Carcinogenesis

KW - Colorectal Neoplasms

KW - Colorectal cancer

KW - Dysbiosis

KW - Humans

KW - Oncology

KW - Oxidative Stress

KW - Oxidative stress

KW - Reactive Oxygen Species

KW - Review

KW - Animals

KW - Antioxidants

KW - Cancer Research

KW - Carcinogenesis

KW - Colorectal Neoplasms

KW - Colorectal cancer

KW - Dysbiosis

KW - Humans

KW - Oncology

KW - Oxidative Stress

KW - Oxidative stress

KW - Reactive Oxygen Species

KW - Review

UR - http://hdl.handle.net/10447/242104

UR - http://ar.iiarjournals.org/content/37/9/4759.full.pdf

M3 - Article

VL - 37

SP - 4759

EP - 4766

JO - Anticancer Research

JF - Anticancer Research

SN - 0250-7005

ER -