COLORECTAL CANCER: AN UPDATE ON THE EFFECTS OF LYCOPENE ON TUMOR PROGRESSION AND CELL PROLIFERATION

Giovanni Tomasello, Francesco Carini, Francesca Rappa, Sabrina David, Angelo Leone, Francesco Cappello, Rosalyn Jurjus, Battaglia, Rappa, Margherita Mazzola, Alice Gerges Geagea, Tomasello, Battaglia, Jurjus, Cappello

Risultato della ricerca: Article

9 Citazioni (Scopus)

Abstract

Colorectal cancer (CRC) is one of the most common cancers worldwide. Various factors, including oxidative stress, where excessive productions of reactive oxygen species (ROS) and reactive nitrogen species (RNS) occur, contribute to its pathogenesis. Numerous studies have investigated the effect of antioxidant substances derived from food such fruits and vegetables; however, data on Lycopene are still rare. Stidies on HT-29 colorectal cancer cells and on animal models have shown that Lycopene has effects on cell proliferation and on the progression of the CRC by interacting with variuos cellular signaling pathways. this analysis of the literature focused on the antioxidant effect of Lycopene, a substance that is found in the tomato.
Lingua originaleEnglish
pagine (da-a)774-796
Numero di pagine23
RivistaJOURNAL OF BIOLOGICAL REGULATORS & HOMEOSTATIC AGENTS
Volume31
Stato di pubblicazionePublished - 2017

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All Science Journal Classification (ASJC) codes

  • Endocrinology, Diabetes and Metabolism
  • Immunology and Allergy
  • Physiology
  • Immunology
  • Oncology
  • Endocrinology
  • Physiology (medical)
  • Cancer Research

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