Cognitive impairment and its relation with disease measures in mildly disabled patients with relapsing-remitting multiple sclerosis: baseline results from the Cognitive Impairment in Multiple Sclerosis (COGIMUS) study.

Giuseppe Salemi; null Di Monte; null De Caro; null Orefice; null Picconi; null Rosati; null Batocchi; null Cottone; Mr Tola; null Neri; Valentina Zipoli; null Ferrazza; null Caniatti; null Todaro; null Gigli; Giuseppe Salemi; null Centonze; null Gallo; null Ragno; null Signorino; null Zolo; null Scarpini; null Scarpini; null Vecchio; null De Caro; null Vecchio; null Goretti; null Portaccio; null Lo Fermo; Daniele Spitaleri; null Falcini; null Motti; Vincenzo Brescia Brescia Morra; null Maimone; null Zolo; Michele Ragno; null Florio; null Signorino; Edoardo Sessa; null Salemi; null Perini; null Luccichenti; null Tartaglione; null Lugaresi; Luigi Murri; Placido Bramanti; null Trojano; null Carolei; Claudio Gasperini; null Ghezzi; Silvia Messina; null Vecchio; null Bastianello; Antonio Bertolotto; null Zaffaroni; null Tola; null Montanari; Luigi M.E. Grimaldi; null Patti; null Durelli; null Provinciali; null Zorzon; null Giuliani; null Monaco; null Ruggieri; Giulio Rosati; Maria Pia Amato; Pietro Attilio Tonali; null Paciello

Cognitive impairment and its relation with disease measures in mildly disabled patients with relapsing-remitting multiple sclerosis: baseline results from the Cognitive Impairment in Multiple Sclerosis (COGIMUS) study.

Giuseppe Salemi, Di Monte, De Caro, Orefice, Picconi, Rosati, Batocchi, Cottone, Mr Tola, Neri, Valentina Zipoli, Ferrazza, Caniatti, Todaro, Gigli, Giuseppe Salemi, Centonze, Gallo, Ragno, SignorinoZolo, Scarpini, Scarpini, Vecchio, De Caro, Vecchio, Goretti, Portaccio, Lo Fermo, Daniele Spitaleri, Falcini, Motti, Vincenzo Brescia Brescia Morra, Maimone, Zolo, Michele Ragno, Florio, Signorino, Edoardo Sessa, Salemi, Perini, Luccichenti, Tartaglione, Lugaresi, Luigi Murri, Placido Bramanti, Trojano, Carolei, Claudio Gasperini, Ghezzi, Silvia Messina, Vecchio, Bastianello, Antonio Bertolotto, Zaffaroni, Tola, Montanari, Luigi M.E. Grimaldi, Patti, Durelli, Provinciali, Zorzon, Giuliani, Monaco, Ruggieri, Giulio Rosati, Maria Pia Amato, Pietro Attilio Tonali, Paciello

Biomedicina, Neuroscienze e Diagnostica avanzata

Risultato della ricerca: Article › peer review

136 Citazioni (Scopus)

Abstract

Background: Cognitive impairment is a common symptom of multiple sclerosis (MS), but the association between cognitive impairment and magnetic resonance imaging (MRI) disease measures in patients with relapsing-remitting (RR) MS is unclear. Objectives: To study the prevalence of cognitive impairment and its relation with MRI disease measures in mildly disabled patients with RRMS. Methods: Patients aged 18-50 years with RRMS (McDonald criteria) and an Expanded Disability Status Scale (EDSS) score ≤4.0, who were enrolled in the Cognitive Impairment in Multiple Sclerosis (COGIMUS) study, underwent baseline standardized MRI complete neurological examination and neuropsychological testing. Results: A total of 550 patients were enrolled, 327 of whom underwent MRI assessments. Cognitive impairment (impaired performance in ≥3 cognitive tests) was present in approximately 20% of all patients and in the subgroup who underwent MRI. T2 hyperintense and T1 hypointense lesion volumes were significantly higher in patients with cognitive impairment (defined as impaired performance on at least three tests of the Rao's battery) than those without. EDSS score was also significantly higher in cognitively impaired than in cognitively preserved patients. Disease duration, depression, and years in formal education did not differ significantly between cognitively impaired and cognitively preserved patients. T2 lesion volume, performance intelligence quotient, and age were significant predictors of cognitive impairment in this population. Weak correlations were found between performance on individual cognitive tests and specific MRI measures, with T1 and T2 lesion volumes correlating with performance on most cognitive tests. Conclusions: Cognitive impairment occurs in approximately one-fifth of mildly disabled patients with MS and is associated with specific MRI disease measures. Assessment of cognitive function at diagnosis could facilitate the identification of patients who may benefit from therapeutic intervention with disease-modifying therapies to prevent further lesion development.

Lingua originale	English
pagine (da-a)	779-788
Numero di pagine	10
Rivista	Multiple Sclerosis
Volume	15
Stato di pubblicazione	Published - 2009

All Science Journal Classification (ASJC) codes

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Salemi, G., Di Monte, De Caro, Orefice, Picconi, Rosati, Batocchi, Cottone, Tola, M., Neri, Zipoli, V., Ferrazza, Caniatti, Todaro, Gigli, Salemi, G., Centonze, Gallo, Ragno, ... Paciello (2009). Cognitive impairment and its relation with disease measures in mildly disabled patients with relapsing-remitting multiple sclerosis: baseline results from the Cognitive Impairment in Multiple Sclerosis (COGIMUS) study. Multiple Sclerosis, 15, 779-788.

Salemi, G, Di Monte, De Caro, Orefice, Picconi, Rosati, Batocchi, Cottone, Tola, M, Neri, Zipoli, V, Ferrazza, Caniatti, Todaro, Gigli, Salemi, G, Centonze, Gallo, Ragno, Signorino, Zolo, Scarpini, Scarpini, Vecchio, De Caro, Vecchio, Goretti, Portaccio, Lo Fermo, Spitaleri, D, Falcini, Motti, Brescia Morra, VB, Maimone, Zolo, Ragno, M, Florio, Signorino, Sessa, E, Salemi, Perini, Luccichenti, Tartaglione, Lugaresi, Murri, L, Bramanti, P, Trojano, Carolei, Gasperini, C, Ghezzi, Messina, S, Vecchio, Bastianello, Bertolotto, A, Zaffaroni, Tola, Montanari, Grimaldi, LME, Patti, Durelli, Provinciali, Zorzon, Giuliani, Monaco, Ruggieri, Rosati, G, Amato, MP, Tonali, PA & Paciello 2009, 'Cognitive impairment and its relation with disease measures in mildly disabled patients with relapsing-remitting multiple sclerosis: baseline results from the Cognitive Impairment in Multiple Sclerosis (COGIMUS) study.', Multiple Sclerosis, vol. 15, pagg. 779-788.

@article{3c4cc9abf7a446a4b33ec91d5d05740f,

title = "Cognitive impairment and its relation with disease measures in mildly disabled patients with relapsing-remitting multiple sclerosis: baseline results from the Cognitive Impairment in Multiple Sclerosis (COGIMUS) study.",

abstract = "Background: Cognitive impairment is a common symptom of multiple sclerosis (MS), but the association between cognitive impairment and magnetic resonance imaging (MRI) disease measures in patients with relapsing-remitting (RR) MS is unclear. Objectives: To study the prevalence of cognitive impairment and its relation with MRI disease measures in mildly disabled patients with RRMS. Methods: Patients aged 18-50 years with RRMS (McDonald criteria) and an Expanded Disability Status Scale (EDSS) score ≤4.0, who were enrolled in the Cognitive Impairment in Multiple Sclerosis (COGIMUS) study, underwent baseline standardized MRI complete neurological examination and neuropsychological testing. Results: A total of 550 patients were enrolled, 327 of whom underwent MRI assessments. Cognitive impairment (impaired performance in ≥3 cognitive tests) was present in approximately 20% of all patients and in the subgroup who underwent MRI. T2 hyperintense and T1 hypointense lesion volumes were significantly higher in patients with cognitive impairment (defined as impaired performance on at least three tests of the Rao's battery) than those without. EDSS score was also significantly higher in cognitively impaired than in cognitively preserved patients. Disease duration, depression, and years in formal education did not differ significantly between cognitively impaired and cognitively preserved patients. T2 lesion volume, performance intelligence quotient, and age were significant predictors of cognitive impairment in this population. Weak correlations were found between performance on individual cognitive tests and specific MRI measures, with T1 and T2 lesion volumes correlating with performance on most cognitive tests. Conclusions: Cognitive impairment occurs in approximately one-fifth of mildly disabled patients with MS and is associated with specific MRI disease measures. Assessment of cognitive function at diagnosis could facilitate the identification of patients who may benefit from therapeutic intervention with disease-modifying therapies to prevent further lesion development.",

keywords = "Cognitive impairmet. Cognitive function. Multiple Sclerosis. Neuropsychological assessment., Cognitive impairmet. Cognitive function. Multiple Sclerosis. Neuropsychological assessment.",

author = "Giuseppe Salemi and {Di Monte} and {De Caro} and Orefice and Picconi and Rosati and Batocchi and Cottone and Mr Tola and Neri and Valentina Zipoli and Ferrazza and Caniatti and Todaro and Gigli and Giuseppe Salemi and Centonze and Gallo and Ragno and Signorino and Zolo and Scarpini and Scarpini and Vecchio and {De Caro} and Vecchio and Goretti and Portaccio and {Lo Fermo} and Daniele Spitaleri and Falcini and Motti and {Brescia Morra}, {Vincenzo Brescia} and Maimone and Zolo and Michele Ragno and Florio and Signorino and Edoardo Sessa and Salemi and Perini and Luccichenti and Tartaglione and Lugaresi and Luigi Murri and Placido Bramanti and Trojano and Carolei and Claudio Gasperini and Ghezzi and Silvia Messina and Vecchio and Bastianello and Antonio Bertolotto and Zaffaroni and Tola and Montanari and Grimaldi, {Luigi M.E.} and Patti and Durelli and Provinciali and Zorzon and Giuliani and Monaco and Ruggieri and Giulio Rosati and Amato, {Maria Pia} and Tonali, {Pietro Attilio} and Paciello",

year = "2009",

language = "English",

volume = "15",

pages = "779--788",

journal = "Multiple Sclerosis Journal",

issn = "1352-4585",

publisher = "SAGE Publications Ltd",

}

TY - JOUR

T1 - Cognitive impairment and its relation with disease measures in mildly disabled patients with relapsing-remitting multiple sclerosis: baseline results from the Cognitive Impairment in Multiple Sclerosis (COGIMUS) study.

AU - Salemi, Giuseppe

AU - Di Monte, null

AU - De Caro, null

AU - Orefice, null

AU - Picconi, null

AU - Rosati, null

AU - Batocchi, null

AU - Cottone, null

AU - Tola, Mr

AU - Neri, null

AU - Zipoli, Valentina

AU - Ferrazza, null

AU - Caniatti, null

AU - Todaro, null

AU - Gigli, null

AU - Salemi, Giuseppe

AU - Centonze, null

AU - Gallo, null

AU - Ragno, null

AU - Signorino, null

AU - Zolo, null

AU - Scarpini, null

AU - Vecchio, null

AU - De Caro, null

AU - Vecchio, null

AU - Goretti, null

AU - Portaccio, null

AU - Lo Fermo, null

AU - Spitaleri, Daniele

AU - Falcini, null

AU - Motti, null

AU - Brescia Morra, Vincenzo Brescia

AU - Maimone, null

AU - Zolo, null

AU - Ragno, Michele

AU - Florio, null

AU - Signorino, null

AU - Sessa, Edoardo

AU - Salemi, null

AU - Perini, null

AU - Luccichenti, null

AU - Tartaglione, null

AU - Lugaresi, null

AU - Murri, Luigi

AU - Bramanti, Placido

AU - Trojano, null

AU - Carolei, null

AU - Gasperini, Claudio

AU - Ghezzi, null

AU - Messina, Silvia

AU - Vecchio, null

AU - Bastianello, null

AU - Bertolotto, Antonio

AU - Zaffaroni, null

AU - Tola, null

AU - Montanari, null

AU - Grimaldi, Luigi M.E.

AU - Patti, null

AU - Durelli, null

AU - Provinciali, null

AU - Zorzon, null

AU - Giuliani, null

AU - Monaco, null

AU - Ruggieri, null

AU - Rosati, Giulio

AU - Amato, Maria Pia

AU - Tonali, Pietro Attilio

AU - Paciello, null

PY - 2009

Y1 - 2009

N2 - Background: Cognitive impairment is a common symptom of multiple sclerosis (MS), but the association between cognitive impairment and magnetic resonance imaging (MRI) disease measures in patients with relapsing-remitting (RR) MS is unclear. Objectives: To study the prevalence of cognitive impairment and its relation with MRI disease measures in mildly disabled patients with RRMS. Methods: Patients aged 18-50 years with RRMS (McDonald criteria) and an Expanded Disability Status Scale (EDSS) score ≤4.0, who were enrolled in the Cognitive Impairment in Multiple Sclerosis (COGIMUS) study, underwent baseline standardized MRI complete neurological examination and neuropsychological testing. Results: A total of 550 patients were enrolled, 327 of whom underwent MRI assessments. Cognitive impairment (impaired performance in ≥3 cognitive tests) was present in approximately 20% of all patients and in the subgroup who underwent MRI. T2 hyperintense and T1 hypointense lesion volumes were significantly higher in patients with cognitive impairment (defined as impaired performance on at least three tests of the Rao's battery) than those without. EDSS score was also significantly higher in cognitively impaired than in cognitively preserved patients. Disease duration, depression, and years in formal education did not differ significantly between cognitively impaired and cognitively preserved patients. T2 lesion volume, performance intelligence quotient, and age were significant predictors of cognitive impairment in this population. Weak correlations were found between performance on individual cognitive tests and specific MRI measures, with T1 and T2 lesion volumes correlating with performance on most cognitive tests. Conclusions: Cognitive impairment occurs in approximately one-fifth of mildly disabled patients with MS and is associated with specific MRI disease measures. Assessment of cognitive function at diagnosis could facilitate the identification of patients who may benefit from therapeutic intervention with disease-modifying therapies to prevent further lesion development.

AB - Background: Cognitive impairment is a common symptom of multiple sclerosis (MS), but the association between cognitive impairment and magnetic resonance imaging (MRI) disease measures in patients with relapsing-remitting (RR) MS is unclear. Objectives: To study the prevalence of cognitive impairment and its relation with MRI disease measures in mildly disabled patients with RRMS. Methods: Patients aged 18-50 years with RRMS (McDonald criteria) and an Expanded Disability Status Scale (EDSS) score ≤4.0, who were enrolled in the Cognitive Impairment in Multiple Sclerosis (COGIMUS) study, underwent baseline standardized MRI complete neurological examination and neuropsychological testing. Results: A total of 550 patients were enrolled, 327 of whom underwent MRI assessments. Cognitive impairment (impaired performance in ≥3 cognitive tests) was present in approximately 20% of all patients and in the subgroup who underwent MRI. T2 hyperintense and T1 hypointense lesion volumes were significantly higher in patients with cognitive impairment (defined as impaired performance on at least three tests of the Rao's battery) than those without. EDSS score was also significantly higher in cognitively impaired than in cognitively preserved patients. Disease duration, depression, and years in formal education did not differ significantly between cognitively impaired and cognitively preserved patients. T2 lesion volume, performance intelligence quotient, and age were significant predictors of cognitive impairment in this population. Weak correlations were found between performance on individual cognitive tests and specific MRI measures, with T1 and T2 lesion volumes correlating with performance on most cognitive tests. Conclusions: Cognitive impairment occurs in approximately one-fifth of mildly disabled patients with MS and is associated with specific MRI disease measures. Assessment of cognitive function at diagnosis could facilitate the identification of patients who may benefit from therapeutic intervention with disease-modifying therapies to prevent further lesion development.

KW - Cognitive impairmet. Cognitive function. Multiple Sclerosis. Neuropsychological assessment.

UR - http://hdl.handle.net/10447/61969

M3 - Article

VL - 15

SP - 779

EP - 788

JO - Multiple Sclerosis Journal

JF - Multiple Sclerosis Journal

SN - 1352-4585

ER -