Cognitive dysfunction in patients with relapsing-remitting multiple sclerosis.

Giovanni Savettieri, Giuseppe Salemi, Maria Buccafusca, Paola Valentino, Ugo Nocentini, Simona Bonavita, Francesco Le Pira, Paolo Girlanda, Lugaresi, Farina, Reggio, Trojano, Pasqualetti, Aldo Quattrone, Gioacchino Tedeschi, De Caro, Carlo Caltagirone

Risultato della ricerca: Article

83 Citazioni (Scopus)

Abstract

Cognitive dysfunction is considered one of the clinical markers of multiple sclerosis (MS). However, in the literature there are inconsistent reports on the prevalence of cognitive dysfunction, and separate data for the relapsing-remitting (RR) type of the disease are not always presented. In this study, we submitted 461 RRMS patients to a battery of neuropsychological tests to investigate their impairment in various cognitive domains. As a consequence of the exclusion criteria, the sample is not fully representative of the entire population of RRMS patients. In this selected sample, when only the eight scores of a core battery (Mental Deterioration Battery) were considered (with respective cutoffs), it emerged that 31% of the patients were affected by some degree of cognitive deficit. In particular, 15% had mild, 11.2% moderate and 4.8% had severe impairment. Information processing speed was the most frequently impaired area, followed by memory. When two other tests (SDMT and MCST) were added and cognitive domains were considered, it emerged that 39.3% of the patients were impaired in two or more domains. When four subgroups were obtained by means of cluster analysis and then compared, it emerged that information processing speed and memory deficits differentiated the still cognitively unimpaired from the mildly impaired MS patients. Significant associations were found between cognitive and clinical characteristics. However, due to the large sample size, clinically irrelevant relationships may also have emerged. Even with the limitations imposed by the sample selection and the possible underestimation of the prevalence and severity of cognitive dysfunction, these results seem to provide further evidence that information processing speed deficit may be an early and important marker of cognitive impairment in MS patients.
Lingua originaleEnglish
pagine (da-a)77-87
RivistaMultiple Sclerosis
Volume12
Stato di pubblicazionePublished - 2006

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Relapsing-Remitting Multiple Sclerosis
Automatic Data Processing
Multiple Sclerosis
Neuropsychological Tests
Memory Disorders
Sample Size
Cluster Analysis
Cognitive Dysfunction
Biomarkers
Population

All Science Journal Classification (ASJC) codes

  • Neurology
  • Clinical Neurology

Cita questo

Savettieri, G., Salemi, G., Buccafusca, M., Valentino, P., Nocentini, U., Bonavita, S., ... Caltagirone, C. (2006). Cognitive dysfunction in patients with relapsing-remitting multiple sclerosis. Multiple Sclerosis, 12, 77-87.

Cognitive dysfunction in patients with relapsing-remitting multiple sclerosis. / Savettieri, Giovanni; Salemi, Giuseppe; Buccafusca, Maria; Valentino, Paola; Nocentini, Ugo; Bonavita, Simona; Le Pira, Francesco; Girlanda, Paolo; Lugaresi; Farina; Reggio; Trojano; Pasqualetti; Quattrone, Aldo; Tedeschi, Gioacchino; De Caro; Caltagirone, Carlo.

In: Multiple Sclerosis, Vol. 12, 2006, pag. 77-87.

Risultato della ricerca: Article

Savettieri, G, Salemi, G, Buccafusca, M, Valentino, P, Nocentini, U, Bonavita, S, Le Pira, F, Girlanda, P, Lugaresi, Farina, Reggio, Trojano, Pasqualetti, Quattrone, A, Tedeschi, G, De Caro & Caltagirone, C 2006, 'Cognitive dysfunction in patients with relapsing-remitting multiple sclerosis.', Multiple Sclerosis, vol. 12, pagg. 77-87.
Savettieri G, Salemi G, Buccafusca M, Valentino P, Nocentini U, Bonavita S e altri. Cognitive dysfunction in patients with relapsing-remitting multiple sclerosis. Multiple Sclerosis. 2006;12:77-87.
Savettieri, Giovanni ; Salemi, Giuseppe ; Buccafusca, Maria ; Valentino, Paola ; Nocentini, Ugo ; Bonavita, Simona ; Le Pira, Francesco ; Girlanda, Paolo ; Lugaresi ; Farina ; Reggio ; Trojano ; Pasqualetti ; Quattrone, Aldo ; Tedeschi, Gioacchino ; De Caro ; Caltagirone, Carlo. / Cognitive dysfunction in patients with relapsing-remitting multiple sclerosis. In: Multiple Sclerosis. 2006 ; Vol. 12. pagg. 77-87.
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abstract = "Cognitive dysfunction is considered one of the clinical markers of multiple sclerosis (MS). However, in the literature there are inconsistent reports on the prevalence of cognitive dysfunction, and separate data for the relapsing-remitting (RR) type of the disease are not always presented. In this study, we submitted 461 RRMS patients to a battery of neuropsychological tests to investigate their impairment in various cognitive domains. As a consequence of the exclusion criteria, the sample is not fully representative of the entire population of RRMS patients. In this selected sample, when only the eight scores of a core battery (Mental Deterioration Battery) were considered (with respective cutoffs), it emerged that 31{\%} of the patients were affected by some degree of cognitive deficit. In particular, 15{\%} had mild, 11.2{\%} moderate and 4.8{\%} had severe impairment. Information processing speed was the most frequently impaired area, followed by memory. When two other tests (SDMT and MCST) were added and cognitive domains were considered, it emerged that 39.3{\%} of the patients were impaired in two or more domains. When four subgroups were obtained by means of cluster analysis and then compared, it emerged that information processing speed and memory deficits differentiated the still cognitively unimpaired from the mildly impaired MS patients. Significant associations were found between cognitive and clinical characteristics. However, due to the large sample size, clinically irrelevant relationships may also have emerged. Even with the limitations imposed by the sample selection and the possible underestimation of the prevalence and severity of cognitive dysfunction, these results seem to provide further evidence that information processing speed deficit may be an early and important marker of cognitive impairment in MS patients.",
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T1 - Cognitive dysfunction in patients with relapsing-remitting multiple sclerosis.

AU - Savettieri, Giovanni

AU - Salemi, Giuseppe

AU - Buccafusca, Maria

AU - Valentino, Paola

AU - Nocentini, Ugo

AU - Bonavita, Simona

AU - Le Pira, Francesco

AU - Girlanda, Paolo

AU - Lugaresi, null

AU - Farina, null

AU - Reggio, null

AU - Trojano, null

AU - Pasqualetti, null

AU - Quattrone, Aldo

AU - Tedeschi, Gioacchino

AU - De Caro, null

AU - Caltagirone, Carlo

PY - 2006

Y1 - 2006

N2 - Cognitive dysfunction is considered one of the clinical markers of multiple sclerosis (MS). However, in the literature there are inconsistent reports on the prevalence of cognitive dysfunction, and separate data for the relapsing-remitting (RR) type of the disease are not always presented. In this study, we submitted 461 RRMS patients to a battery of neuropsychological tests to investigate their impairment in various cognitive domains. As a consequence of the exclusion criteria, the sample is not fully representative of the entire population of RRMS patients. In this selected sample, when only the eight scores of a core battery (Mental Deterioration Battery) were considered (with respective cutoffs), it emerged that 31% of the patients were affected by some degree of cognitive deficit. In particular, 15% had mild, 11.2% moderate and 4.8% had severe impairment. Information processing speed was the most frequently impaired area, followed by memory. When two other tests (SDMT and MCST) were added and cognitive domains were considered, it emerged that 39.3% of the patients were impaired in two or more domains. When four subgroups were obtained by means of cluster analysis and then compared, it emerged that information processing speed and memory deficits differentiated the still cognitively unimpaired from the mildly impaired MS patients. Significant associations were found between cognitive and clinical characteristics. However, due to the large sample size, clinically irrelevant relationships may also have emerged. Even with the limitations imposed by the sample selection and the possible underestimation of the prevalence and severity of cognitive dysfunction, these results seem to provide further evidence that information processing speed deficit may be an early and important marker of cognitive impairment in MS patients.

AB - Cognitive dysfunction is considered one of the clinical markers of multiple sclerosis (MS). However, in the literature there are inconsistent reports on the prevalence of cognitive dysfunction, and separate data for the relapsing-remitting (RR) type of the disease are not always presented. In this study, we submitted 461 RRMS patients to a battery of neuropsychological tests to investigate their impairment in various cognitive domains. As a consequence of the exclusion criteria, the sample is not fully representative of the entire population of RRMS patients. In this selected sample, when only the eight scores of a core battery (Mental Deterioration Battery) were considered (with respective cutoffs), it emerged that 31% of the patients were affected by some degree of cognitive deficit. In particular, 15% had mild, 11.2% moderate and 4.8% had severe impairment. Information processing speed was the most frequently impaired area, followed by memory. When two other tests (SDMT and MCST) were added and cognitive domains were considered, it emerged that 39.3% of the patients were impaired in two or more domains. When four subgroups were obtained by means of cluster analysis and then compared, it emerged that information processing speed and memory deficits differentiated the still cognitively unimpaired from the mildly impaired MS patients. Significant associations were found between cognitive and clinical characteristics. However, due to the large sample size, clinically irrelevant relationships may also have emerged. Even with the limitations imposed by the sample selection and the possible underestimation of the prevalence and severity of cognitive dysfunction, these results seem to provide further evidence that information processing speed deficit may be an early and important marker of cognitive impairment in MS patients.

KW - cognition impairment; information processing speed; multiple sclerosis; relapsing remitting

UR - http://hdl.handle.net/10447/12375

M3 - Article

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SP - 77

EP - 87

JO - Multiple Sclerosis Journal

JF - Multiple Sclerosis Journal

SN - 1352-4585

ER -