Cocirculation of Hajj and non-Hajj strains among serogroup W meningococci in Italy, 2000 to 2016

Anna Giammanco, Rosella De Nittis, Irene Alessandra Galanti, Caterina Vocale, Elisabetta Pagani, Paola Vacca, Alessandro Bisbano, Patrizia Isola, Elisabetta Pagani, Paola Bernaschi, Milena Arghittu, Andrea Ciammaruconi, Paola Stefanelli, Anna Maria Barbui, Maria Chironna, Antonella Mencacci, Cecilia Fazio, Arianna Neri

Risultato della ricerca: Articlepeer review

7 Citazioni (Scopus)

Abstract

In Italy, B and C are the predominant serogroups among meningococci causing invasive diseases. Nevertheless, in the period from 2013 to 2016, an increase in serogroup W Neisseria meningitidis (MenW) was observed. This study intends to define the main characteristics of 63 MenW isolates responsible of invasive meningococcal disease (IMD) in Italy from 2000 to 2016. We performed whole genome sequencing on bacterial isolates or single gene sequencing on culturenegative samples to evaluate molecular heterogeneity. Our main finding was the cocirculation of the Hajj and the South American sublineages belonging to MenW/ clonal complex (cc)11, which gradually surpassed the MenW/cc22 in Italy. All MenW/cc11 isolates were fully susceptible to cefotaxime, ceftriaxone, ciprofloxacin, penicillin G and rifampicin. We identified the fulllength NadA protein variant 2/3, present in all the MenW/cc11. We also identified the fHbp variant 1, which we found exclusively in the MenW/cc11/Hajj sublineage. Concern about the epidemic potential of MenW/cc11 has increased worldwide since the year 2000. Continued surveillance, supported by genomic characterisation, allows high-resolution tracking of pathogen dissemination and the detection of epidemicassociated strains.
Lingua originaleEnglish
pagine (da-a)33-41
Numero di pagine9
RivistaEurosurveillance
Volume24
Stato di pubblicazionePublished - 2019

All Science Journal Classification (ASJC) codes

  • Epidemiology
  • Public Health, Environmental and Occupational Health
  • Virology

Fingerprint Entra nei temi di ricerca di 'Cocirculation of Hajj and non-Hajj strains among serogroup W meningococci in Italy, 2000 to 2016'. Insieme formano una fingerprint unica.

Cita questo