Co-occurrence of resonant activation and noise-enhanced stability in a model of cancer growth in the presence of immune response

Alessandro Fiasconaro, Bernardo Spagnolo, Ewa Gudowska-Nowak, Anna Ochab-Marcinek

Risultato della ricerca: Articlepeer review

95 Citazioni (Scopus)

Abstract

We investigate a stochastic version of a simple enzymatic reaction which follows the generic Michaelis-Menten kinetics. At sufficiently high concentrations of reacting species, that represent here populations of cells involved in cancerous proliferation and cytotoxic response of the immune system, the overall kinetics can be approximated by a one-dimensional overdamped Langevin equation. The modulating activity of the immune response is here modeled as a dichotomous random process of the relative rate of neoplastic cell destruction. We discuss physical aspects of environmental noises acting in such a system, pointing out the possibility of coexistence of dynamical regimes where noise-enhanced stability and resonant activation phenomena can be observed together. We explain the underlying mechanisms by analyzing the behavior of the variance of first passage times as a function of the noise intensity.
Lingua originaleEnglish
pagine (da-a)1-10
Numero di pagine10
RivistaPHYSICAL REVIEW E, STATISTICAL, NONLINEAR, AND SOFT MATTER PHYSICS
Volume74
Stato di pubblicazionePublished - 2006

All Science Journal Classification (ASJC) codes

  • Statistical and Nonlinear Physics
  • Statistics and Probability
  • Condensed Matter Physics

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