Co-colonization with carbapenem-resistant Klebsiella pneumoniae and Acinetobacter baumannii in intensive care unit patients.

Celestino Bonura, Caterina Mammina, Laura Saporito, Francesca Di Bernardo, Romano Tetamo, Daniela Maria Palma, Andrea Neville Cracchiolo, Maria Antonietta Saporito, Maria Stella Verde, Anna Rita Vivoli, Andrea Neville Cracchiolo, Concetta Sodano, Pier Giorgio Fabbri

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Abstract

Objectives: This investigation was conducted to study co-colonization by carbapenem-resistant Klebsiella pneumoniae carbapenemase-producing K. pneumoniae (KPC-Kp) and Acinetobacter baumannii (CRAB) in intensive care unit (ICU) patients in Palermo, Sicily, a geographic area where both organisms are endemic in the healthcare setting. Risk factors at admission and during ICU stay and outcomes were also evaluated. Methods: All patients colonized by KPC-Kp, or CRAB, or both in 2 ICUs of a large general hospital during the period October 2011-March 2012 were enrolled. Demographics and clinical data were collected. Resistance determinants and clonality of the 2 organisms were characterized by molecular methods. Results: Seventy-five of 391 patients (19.2%) proved to be colonized by KPC-Kp, CRAB, or both: 30 (40%) were co-colonized and 44 (58.7%) were mono-colonized by CRAB and 1 by KPC-Kp. Younger age, major trauma, and length of stay were positively associated with co-colonization. However, no significant differences were detected between co-colonized and non co-colonized patients in infection and ICU mortality rates and length of stay after the first isolation. Both organisms proved to be circulating in a clonal way. Conclusions: In our setting, co-colonization by KPC-Kp and CRAB disproportionately affected young trauma patients with those with a prolonged ICU stay.
Lingua originaleEnglish
pagine (da-a)629-634
Numero di pagine6
RivistaSCANDINAVIAN JOURNAL OF INFECTIOUS DISEASES
Volume2013 Apr 8. [Epub ahead of print]
Stato di pubblicazionePublished - 2013

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All Science Journal Classification (ASJC) codes

  • Immunology and Microbiology(all)
  • Microbiology (medical)
  • Infectious Diseases

Cita questo

Bonura, C., Mammina, C., Saporito, L., Di Bernardo, F., Tetamo, R., Palma, D. M., Cracchiolo, A. N., Saporito, M. A., Verde, M. S., Vivoli, A. R., Cracchiolo, A. N., Sodano, C., & Fabbri, P. G. (2013). Co-colonization with carbapenem-resistant Klebsiella pneumoniae and Acinetobacter baumannii in intensive care unit patients. SCANDINAVIAN JOURNAL OF INFECTIOUS DISEASES, 2013 Apr 8. [Epub ahead of print], 629-634.