Co-colonization with carbapenem-resistant Klebsiella pneumoniae and Acinetobacter baumannii in intensive care unit patients.

Caterina Mammina, Celestino Bonura, Laura Saporito, Concetta Sodano, Pier Giorgio Fabbri, Francesca Di Bernardo, Romano Tetamo, Daniela Maria Palma, Andrea Neville Cracchiolo, Maria Antonietta Saporito, Maria Stella Verde, Anna Rita Vivoli

Risultato della ricerca: Article

12 Citazioni (Scopus)

Abstract

Objectives: This investigation was conducted to study co-colonization by carbapenem-resistant Klebsiella pneumoniae carbapenemase-producing K. pneumoniae (KPC-Kp) and Acinetobacter baumannii (CRAB) in intensive care unit (ICU) patients in Palermo, Sicily, a geographic area where both organisms are endemic in the healthcare setting. Risk factors at admission and during ICU stay and outcomes were also evaluated. Methods: All patients colonized by KPC-Kp, or CRAB, or both in 2 ICUs of a large general hospital during the period October 2011-March 2012 were enrolled. Demographics and clinical data were collected. Resistance determinants and clonality of the 2 organisms were characterized by molecular methods. Results: Seventy-five of 391 patients (19.2%) proved to be colonized by KPC-Kp, CRAB, or both: 30 (40%) were co-colonized and 44 (58.7%) were mono-colonized by CRAB and 1 by KPC-Kp. Younger age, major trauma, and length of stay were positively associated with co-colonization. However, no significant differences were detected between co-colonized and non co-colonized patients in infection and ICU mortality rates and length of stay after the first isolation. Both organisms proved to be circulating in a clonal way. Conclusions: In our setting, co-colonization by KPC-Kp and CRAB disproportionately affected young trauma patients with those with a prolonged ICU stay.
Lingua originaleEnglish
pagine (da-a)629-634
Numero di pagine6
RivistaScandinavian Journal of Infectious Diseases
Volume2013 Apr 8. [Epub ahead of print]
Stato di pubblicazionePublished - 2013

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Acinetobacter baumannii
Carbapenems
Klebsiella pneumoniae
Intensive Care Units
Length of Stay
Sicily
Wounds and Injuries
General Hospitals
Demography
Delivery of Health Care
Mortality
carbapenemase

All Science Journal Classification (ASJC) codes

  • Microbiology (medical)
  • Infectious Diseases
  • Immunology and Microbiology(all)

Cita questo

Co-colonization with carbapenem-resistant Klebsiella pneumoniae and Acinetobacter baumannii in intensive care unit patients. / Mammina, Caterina; Bonura, Celestino; Saporito, Laura; Sodano, Concetta; Fabbri, Pier Giorgio; Di Bernardo, Francesca; Tetamo, Romano; Palma, Daniela Maria; Cracchiolo, Andrea Neville; Saporito, Maria Antonietta; Verde, Maria Stella; Vivoli, Anna Rita.

In: Scandinavian Journal of Infectious Diseases, Vol. 2013 Apr 8. [Epub ahead of print], 2013, pag. 629-634.

Risultato della ricerca: Article

Mammina, C, Bonura, C, Saporito, L, Sodano, C, Fabbri, PG, Di Bernardo, F, Tetamo, R, Palma, DM, Cracchiolo, AN, Saporito, MA, Verde, MS & Vivoli, AR 2013, 'Co-colonization with carbapenem-resistant Klebsiella pneumoniae and Acinetobacter baumannii in intensive care unit patients.', Scandinavian Journal of Infectious Diseases, vol. 2013 Apr 8. [Epub ahead of print], pagg. 629-634.
Mammina, Caterina ; Bonura, Celestino ; Saporito, Laura ; Sodano, Concetta ; Fabbri, Pier Giorgio ; Di Bernardo, Francesca ; Tetamo, Romano ; Palma, Daniela Maria ; Cracchiolo, Andrea Neville ; Saporito, Maria Antonietta ; Verde, Maria Stella ; Vivoli, Anna Rita. / Co-colonization with carbapenem-resistant Klebsiella pneumoniae and Acinetobacter baumannii in intensive care unit patients. In: Scandinavian Journal of Infectious Diseases. 2013 ; Vol. 2013 Apr 8. [Epub ahead of print]. pagg. 629-634.
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title = "Co-colonization with carbapenem-resistant Klebsiella pneumoniae and Acinetobacter baumannii in intensive care unit patients.",
abstract = "Objectives: This investigation was conducted to study co-colonization by carbapenem-resistant Klebsiella pneumoniae carbapenemase-producing K. pneumoniae (KPC-Kp) and Acinetobacter baumannii (CRAB) in intensive care unit (ICU) patients in Palermo, Sicily, a geographic area where both organisms are endemic in the healthcare setting. Risk factors at admission and during ICU stay and outcomes were also evaluated. Methods: All patients colonized by KPC-Kp, or CRAB, or both in 2 ICUs of a large general hospital during the period October 2011-March 2012 were enrolled. Demographics and clinical data were collected. Resistance determinants and clonality of the 2 organisms were characterized by molecular methods. Results: Seventy-five of 391 patients (19.2{\%}) proved to be colonized by KPC-Kp, CRAB, or both: 30 (40{\%}) were co-colonized and 44 (58.7{\%}) were mono-colonized by CRAB and 1 by KPC-Kp. Younger age, major trauma, and length of stay were positively associated with co-colonization. However, no significant differences were detected between co-colonized and non co-colonized patients in infection and ICU mortality rates and length of stay after the first isolation. Both organisms proved to be circulating in a clonal way. Conclusions: In our setting, co-colonization by KPC-Kp and CRAB disproportionately affected young trauma patients with those with a prolonged ICU stay.",
author = "Caterina Mammina and Celestino Bonura and Laura Saporito and Concetta Sodano and Fabbri, {Pier Giorgio} and {Di Bernardo}, Francesca and Romano Tetamo and Palma, {Daniela Maria} and Cracchiolo, {Andrea Neville} and Saporito, {Maria Antonietta} and Verde, {Maria Stella} and Vivoli, {Anna Rita}",
year = "2013",
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pages = "629--634",
journal = "Scandinavian Journal of Infectious Diseases",
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TY - JOUR

T1 - Co-colonization with carbapenem-resistant Klebsiella pneumoniae and Acinetobacter baumannii in intensive care unit patients.

AU - Mammina, Caterina

AU - Bonura, Celestino

AU - Saporito, Laura

AU - Sodano, Concetta

AU - Fabbri, Pier Giorgio

AU - Di Bernardo, Francesca

AU - Tetamo, Romano

AU - Palma, Daniela Maria

AU - Cracchiolo, Andrea Neville

AU - Saporito, Maria Antonietta

AU - Verde, Maria Stella

AU - Vivoli, Anna Rita

PY - 2013

Y1 - 2013

N2 - Objectives: This investigation was conducted to study co-colonization by carbapenem-resistant Klebsiella pneumoniae carbapenemase-producing K. pneumoniae (KPC-Kp) and Acinetobacter baumannii (CRAB) in intensive care unit (ICU) patients in Palermo, Sicily, a geographic area where both organisms are endemic in the healthcare setting. Risk factors at admission and during ICU stay and outcomes were also evaluated. Methods: All patients colonized by KPC-Kp, or CRAB, or both in 2 ICUs of a large general hospital during the period October 2011-March 2012 were enrolled. Demographics and clinical data were collected. Resistance determinants and clonality of the 2 organisms were characterized by molecular methods. Results: Seventy-five of 391 patients (19.2%) proved to be colonized by KPC-Kp, CRAB, or both: 30 (40%) were co-colonized and 44 (58.7%) were mono-colonized by CRAB and 1 by KPC-Kp. Younger age, major trauma, and length of stay were positively associated with co-colonization. However, no significant differences were detected between co-colonized and non co-colonized patients in infection and ICU mortality rates and length of stay after the first isolation. Both organisms proved to be circulating in a clonal way. Conclusions: In our setting, co-colonization by KPC-Kp and CRAB disproportionately affected young trauma patients with those with a prolonged ICU stay.

AB - Objectives: This investigation was conducted to study co-colonization by carbapenem-resistant Klebsiella pneumoniae carbapenemase-producing K. pneumoniae (KPC-Kp) and Acinetobacter baumannii (CRAB) in intensive care unit (ICU) patients in Palermo, Sicily, a geographic area where both organisms are endemic in the healthcare setting. Risk factors at admission and during ICU stay and outcomes were also evaluated. Methods: All patients colonized by KPC-Kp, or CRAB, or both in 2 ICUs of a large general hospital during the period October 2011-March 2012 were enrolled. Demographics and clinical data were collected. Resistance determinants and clonality of the 2 organisms were characterized by molecular methods. Results: Seventy-five of 391 patients (19.2%) proved to be colonized by KPC-Kp, CRAB, or both: 30 (40%) were co-colonized and 44 (58.7%) were mono-colonized by CRAB and 1 by KPC-Kp. Younger age, major trauma, and length of stay were positively associated with co-colonization. However, no significant differences were detected between co-colonized and non co-colonized patients in infection and ICU mortality rates and length of stay after the first isolation. Both organisms proved to be circulating in a clonal way. Conclusions: In our setting, co-colonization by KPC-Kp and CRAB disproportionately affected young trauma patients with those with a prolonged ICU stay.

UR - http://hdl.handle.net/10447/75914

M3 - Article

VL - 2013 Apr 8. [Epub ahead of print]

SP - 629

EP - 634

JO - Scandinavian Journal of Infectious Diseases

JF - Scandinavian Journal of Infectious Diseases

SN - 0036-5548

ER -