Co-circulation of the two influenza B lineages during 13 consecutive influenza surveillance seasons in Italy, 2004–2017 Open Access

Francesco Vitale, Fabio Tramuto, Elena Pariani, Marzia Facchini, Laura Calzoletti, Rosaria Arvia, Annapina Palmieri, Elisabetta Pagani, Maria Rosaria Capobianchi, Caterina Serra, Simona Puzelli, Giuseppina Di Mario, Alberta Azzi, Angela Di Martino, Paola Affanni, Silvana Castaldi, Riccardo Smeraglia, Filippo Ansaldi, Simone Giannecchini, Maria ChironnaPierlanfranco D'Agaro, Concetta Fabiani, Isabella Donatelli, Valeria Ghisetti, Patrizia Bagnarelli, Antonino Bella, Giorgio Palù, Fausto Baldanti, Andrea Orsi, Maria Rosaria Capobianchi, Maria Rita Castrucci, Alberta Azzi, Caterina Serra, Maurizio Sanguinetti, Cristina Galli, Barbara Camilloni, Maria Eugenia Colucci, Caterina Rizzo

Risultato della ricerca: Article

Abstract

Background: Since 1985, two antigenically distinct lineages of influenza B viruses (Victoria-like and Yamagata-like) have circulated globally. Trivalent seasonal influenza vaccines contain two circulating influenza A strains but a single B strain and thus provide limited immunity against circulating B strains of the lineage not included in the vaccine. In this study, we describe the characteristics of influenza B viruses that caused respiratory illness in the population in Italy over 13 consecutive seasons of virological surveillance, and the match between the predominant influenza B lineage and the vaccine B lineage, in each season. Methods: From 2004 to 2017, 26,886 laboratory-confirmed influenza cases were registered in Italy, of which 18.7% were type B. Among them, the lineage of 2465 strains (49%) was retrieved or characterized in this study by a real- time RT-PCR assay and/or sequencing of the hemagglutinin (HA) gene. Results: Co-circulation of both B lineages was observed each season, although in different proportions every year. Overall, viruses of B/Victoria and B/Yamagata lineages caused 53.3 and 46.7% of influenza B infections, respectively. A higher proportion of infections with both lineages was detected in children, and there was a declining frequency of B/Victoria detections with age. A mismatch between the vaccine and the predominant influenza B lineage occurred in eight out of thirteen influenza seasons under study. Considering the seasons when B accounted for > 20% of all laboratory-confirmed influenza cases, a mismatch was observed in four out of six seasons. Phylogenetic analysis of the HA1 domain confirmed the co-circulation of both lineages and revealed a mixed circulation of distinct evolutionary viral variants, with different levels of match to the vaccine strains. Conclusions: This study contributes to the understanding of the circulation of influenza B viruses in Italy. We found a continuous co-circulation of both B lineages in the period 2004–2017, and determined that children were particularly vulnerable to Victoria-lineage influenza B virus infections. An influenza B lineage mismatch with the trivalent vaccine occurred in about two-thirds of cases.
Lingua originaleEnglish
pagine (da-a)990-
Numero di pagine11
RivistaBMC Infectious Diseases
Volume19
Stato di pubblicazionePublished - 2019

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Human Influenza
Italy
Influenza B virus
Victoria
Vaccines
Influenza Vaccines
Cercopithecine Herpesvirus 1
Hemagglutinins
Virus Diseases
Infection
Real-Time Polymerase Chain Reaction
Immunity
Population
Genes

All Science Journal Classification (ASJC) codes

  • Infectious Diseases

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Co-circulation of the two influenza B lineages during 13 consecutive influenza surveillance seasons in Italy, 2004–2017 Open Access. / Vitale, Francesco; Tramuto, Fabio; Pariani, Elena; Facchini, Marzia; Calzoletti, Laura; Arvia, Rosaria; Palmieri, Annapina; Pagani, Elisabetta; Capobianchi, Maria Rosaria; Serra, Caterina; Puzelli, Simona; Mario, Giuseppina Di; Azzi, Alberta; Martino, Angela Di; Affanni, Paola; Castaldi, Silvana; Smeraglia, Riccardo; Ansaldi, Filippo; Giannecchini, Simone; Chironna, Maria; D'Agaro, Pierlanfranco; Fabiani, Concetta; Donatelli, Isabella; Ghisetti, Valeria; Bagnarelli, Patrizia; Bella, Antonino; Palù, Giorgio; Baldanti, Fausto; Orsi, Andrea; Capobianchi, Maria Rosaria; Castrucci, Maria Rita; Azzi, Alberta; Serra, Caterina; Sanguinetti, Maurizio; Galli, Cristina; Camilloni, Barbara; Colucci, Maria Eugenia; Rizzo, Caterina.

In: BMC Infectious Diseases, Vol. 19, 2019, pag. 990-.

Risultato della ricerca: Article

Vitale, F, Tramuto, F, Pariani, E, Facchini, M, Calzoletti, L, Arvia, R, Palmieri, A, Pagani, E, Capobianchi, MR, Serra, C, Puzelli, S, Mario, GD, Azzi, A, Martino, AD, Affanni, P, Castaldi, S, Smeraglia, R, Ansaldi, F, Giannecchini, S, Chironna, M, D'Agaro, P, Fabiani, C, Donatelli, I, Ghisetti, V, Bagnarelli, P, Bella, A, Palù, G, Baldanti, F, Orsi, A, Capobianchi, MR, Castrucci, MR, Azzi, A, Serra, C, Sanguinetti, M, Galli, C, Camilloni, B, Colucci, ME & Rizzo, C 2019, 'Co-circulation of the two influenza B lineages during 13 consecutive influenza surveillance seasons in Italy, 2004–2017 Open Access', BMC Infectious Diseases, vol. 19, pagg. 990-.
Vitale, Francesco ; Tramuto, Fabio ; Pariani, Elena ; Facchini, Marzia ; Calzoletti, Laura ; Arvia, Rosaria ; Palmieri, Annapina ; Pagani, Elisabetta ; Capobianchi, Maria Rosaria ; Serra, Caterina ; Puzelli, Simona ; Mario, Giuseppina Di ; Azzi, Alberta ; Martino, Angela Di ; Affanni, Paola ; Castaldi, Silvana ; Smeraglia, Riccardo ; Ansaldi, Filippo ; Giannecchini, Simone ; Chironna, Maria ; D'Agaro, Pierlanfranco ; Fabiani, Concetta ; Donatelli, Isabella ; Ghisetti, Valeria ; Bagnarelli, Patrizia ; Bella, Antonino ; Palù, Giorgio ; Baldanti, Fausto ; Orsi, Andrea ; Capobianchi, Maria Rosaria ; Castrucci, Maria Rita ; Azzi, Alberta ; Serra, Caterina ; Sanguinetti, Maurizio ; Galli, Cristina ; Camilloni, Barbara ; Colucci, Maria Eugenia ; Rizzo, Caterina. / Co-circulation of the two influenza B lineages during 13 consecutive influenza surveillance seasons in Italy, 2004–2017 Open Access. In: BMC Infectious Diseases. 2019 ; Vol. 19. pagg. 990-.
@article{d60a4b0d17334dd38289d84e836adb98,
title = "Co-circulation of the two influenza B lineages during 13 consecutive influenza surveillance seasons in Italy, 2004–2017 Open Access",
abstract = "Background: Since 1985, two antigenically distinct lineages of influenza B viruses (Victoria-like and Yamagata-like) have circulated globally. Trivalent seasonal influenza vaccines contain two circulating influenza A strains but a single B strain and thus provide limited immunity against circulating B strains of the lineage not included in the vaccine. In this study, we describe the characteristics of influenza B viruses that caused respiratory illness in the population in Italy over 13 consecutive seasons of virological surveillance, and the match between the predominant influenza B lineage and the vaccine B lineage, in each season. Methods: From 2004 to 2017, 26,886 laboratory-confirmed influenza cases were registered in Italy, of which 18.7{\%} were type B. Among them, the lineage of 2465 strains (49{\%}) was retrieved or characterized in this study by a real- time RT-PCR assay and/or sequencing of the hemagglutinin (HA) gene. Results: Co-circulation of both B lineages was observed each season, although in different proportions every year. Overall, viruses of B/Victoria and B/Yamagata lineages caused 53.3 and 46.7{\%} of influenza B infections, respectively. A higher proportion of infections with both lineages was detected in children, and there was a declining frequency of B/Victoria detections with age. A mismatch between the vaccine and the predominant influenza B lineage occurred in eight out of thirteen influenza seasons under study. Considering the seasons when B accounted for > 20{\%} of all laboratory-confirmed influenza cases, a mismatch was observed in four out of six seasons. Phylogenetic analysis of the HA1 domain confirmed the co-circulation of both lineages and revealed a mixed circulation of distinct evolutionary viral variants, with different levels of match to the vaccine strains. Conclusions: This study contributes to the understanding of the circulation of influenza B viruses in Italy. We found a continuous co-circulation of both B lineages in the period 2004–2017, and determined that children were particularly vulnerable to Victoria-lineage influenza B virus infections. An influenza B lineage mismatch with the trivalent vaccine occurred in about two-thirds of cases.",
author = "Francesco Vitale and Fabio Tramuto and Elena Pariani and Marzia Facchini and Laura Calzoletti and Rosaria Arvia and Annapina Palmieri and Elisabetta Pagani and Capobianchi, {Maria Rosaria} and Caterina Serra and Simona Puzelli and Mario, {Giuseppina Di} and Alberta Azzi and Martino, {Angela Di} and Paola Affanni and Silvana Castaldi and Riccardo Smeraglia and Filippo Ansaldi and Simone Giannecchini and Maria Chironna and Pierlanfranco D'Agaro and Concetta Fabiani and Isabella Donatelli and Valeria Ghisetti and Patrizia Bagnarelli and Antonino Bella and Giorgio Pal{\`u} and Fausto Baldanti and Andrea Orsi and Capobianchi, {Maria Rosaria} and Castrucci, {Maria Rita} and Alberta Azzi and Caterina Serra and Maurizio Sanguinetti and Cristina Galli and Barbara Camilloni and Colucci, {Maria Eugenia} and Caterina Rizzo",
year = "2019",
language = "English",
volume = "19",
pages = "990--",
journal = "BMC Infectious Diseases",
issn = "1471-2334",
publisher = "BioMed Central",

}

TY - JOUR

T1 - Co-circulation of the two influenza B lineages during 13 consecutive influenza surveillance seasons in Italy, 2004–2017 Open Access

AU - Vitale, Francesco

AU - Tramuto, Fabio

AU - Pariani, Elena

AU - Facchini, Marzia

AU - Calzoletti, Laura

AU - Arvia, Rosaria

AU - Palmieri, Annapina

AU - Pagani, Elisabetta

AU - Capobianchi, Maria Rosaria

AU - Serra, Caterina

AU - Puzelli, Simona

AU - Mario, Giuseppina Di

AU - Azzi, Alberta

AU - Martino, Angela Di

AU - Affanni, Paola

AU - Castaldi, Silvana

AU - Smeraglia, Riccardo

AU - Ansaldi, Filippo

AU - Giannecchini, Simone

AU - Chironna, Maria

AU - D'Agaro, Pierlanfranco

AU - Fabiani, Concetta

AU - Donatelli, Isabella

AU - Ghisetti, Valeria

AU - Bagnarelli, Patrizia

AU - Bella, Antonino

AU - Palù, Giorgio

AU - Baldanti, Fausto

AU - Orsi, Andrea

AU - Capobianchi, Maria Rosaria

AU - Castrucci, Maria Rita

AU - Azzi, Alberta

AU - Serra, Caterina

AU - Sanguinetti, Maurizio

AU - Galli, Cristina

AU - Camilloni, Barbara

AU - Colucci, Maria Eugenia

AU - Rizzo, Caterina

PY - 2019

Y1 - 2019

N2 - Background: Since 1985, two antigenically distinct lineages of influenza B viruses (Victoria-like and Yamagata-like) have circulated globally. Trivalent seasonal influenza vaccines contain two circulating influenza A strains but a single B strain and thus provide limited immunity against circulating B strains of the lineage not included in the vaccine. In this study, we describe the characteristics of influenza B viruses that caused respiratory illness in the population in Italy over 13 consecutive seasons of virological surveillance, and the match between the predominant influenza B lineage and the vaccine B lineage, in each season. Methods: From 2004 to 2017, 26,886 laboratory-confirmed influenza cases were registered in Italy, of which 18.7% were type B. Among them, the lineage of 2465 strains (49%) was retrieved or characterized in this study by a real- time RT-PCR assay and/or sequencing of the hemagglutinin (HA) gene. Results: Co-circulation of both B lineages was observed each season, although in different proportions every year. Overall, viruses of B/Victoria and B/Yamagata lineages caused 53.3 and 46.7% of influenza B infections, respectively. A higher proportion of infections with both lineages was detected in children, and there was a declining frequency of B/Victoria detections with age. A mismatch between the vaccine and the predominant influenza B lineage occurred in eight out of thirteen influenza seasons under study. Considering the seasons when B accounted for > 20% of all laboratory-confirmed influenza cases, a mismatch was observed in four out of six seasons. Phylogenetic analysis of the HA1 domain confirmed the co-circulation of both lineages and revealed a mixed circulation of distinct evolutionary viral variants, with different levels of match to the vaccine strains. Conclusions: This study contributes to the understanding of the circulation of influenza B viruses in Italy. We found a continuous co-circulation of both B lineages in the period 2004–2017, and determined that children were particularly vulnerable to Victoria-lineage influenza B virus infections. An influenza B lineage mismatch with the trivalent vaccine occurred in about two-thirds of cases.

AB - Background: Since 1985, two antigenically distinct lineages of influenza B viruses (Victoria-like and Yamagata-like) have circulated globally. Trivalent seasonal influenza vaccines contain two circulating influenza A strains but a single B strain and thus provide limited immunity against circulating B strains of the lineage not included in the vaccine. In this study, we describe the characteristics of influenza B viruses that caused respiratory illness in the population in Italy over 13 consecutive seasons of virological surveillance, and the match between the predominant influenza B lineage and the vaccine B lineage, in each season. Methods: From 2004 to 2017, 26,886 laboratory-confirmed influenza cases were registered in Italy, of which 18.7% were type B. Among them, the lineage of 2465 strains (49%) was retrieved or characterized in this study by a real- time RT-PCR assay and/or sequencing of the hemagglutinin (HA) gene. Results: Co-circulation of both B lineages was observed each season, although in different proportions every year. Overall, viruses of B/Victoria and B/Yamagata lineages caused 53.3 and 46.7% of influenza B infections, respectively. A higher proportion of infections with both lineages was detected in children, and there was a declining frequency of B/Victoria detections with age. A mismatch between the vaccine and the predominant influenza B lineage occurred in eight out of thirteen influenza seasons under study. Considering the seasons when B accounted for > 20% of all laboratory-confirmed influenza cases, a mismatch was observed in four out of six seasons. Phylogenetic analysis of the HA1 domain confirmed the co-circulation of both lineages and revealed a mixed circulation of distinct evolutionary viral variants, with different levels of match to the vaccine strains. Conclusions: This study contributes to the understanding of the circulation of influenza B viruses in Italy. We found a continuous co-circulation of both B lineages in the period 2004–2017, and determined that children were particularly vulnerable to Victoria-lineage influenza B virus infections. An influenza B lineage mismatch with the trivalent vaccine occurred in about two-thirds of cases.

UR - http://hdl.handle.net/10447/391761

M3 - Article

VL - 19

SP - 990-

JO - BMC Infectious Diseases

JF - BMC Infectious Diseases

SN - 1471-2334

ER -