Abstract

We report the identification of a cDNA that encodes a putative protein of 94 amino acids and expected molecular weight of 10.7 kDa, the C-terminal half of which is identical to that of PEP19, a small, brain-specific protein involved in Ca++/calmodulin signaling. The novel rat-specific protein, tentatively named long PEP19 isoform (LPI), is the product of alternative splicing of the rat PCP4 gene encoding PEP19. We found that antibodies raised against the first 13 N-terminal amino acids of LPI, not present in PEP19, recognize a protein enriched in the developing rat brain.
Lingua originaleEnglish
pagine (da-a)501-509
Numero di pagine9
RivistaInternational Journal of Molecular Medicine
Volume2007
Stato di pubblicazionePublished - 2007

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Organism Cloning
Protein Isoforms
Proteins
Amino Acids
Brain
Alternative Splicing
Calmodulin
Complementary DNA
Molecular Weight
Antibodies
Genes

All Science Journal Classification (ASJC) codes

  • Genetics

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CLONING OF RAT-SPECIFIC LONG PCP4/PEP19 ISOFORM (LPI). / Di Liegro, Italia; Schiera, Gabriella; Proia, Patrizia; Aflalo-Rattenbach, Revital; Créau, Nicole.

In: International Journal of Molecular Medicine, Vol. 2007, 2007, pag. 501-509.

Risultato della ricerca: Article

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AU - Di Liegro, Italia

AU - Schiera, Gabriella

AU - Proia, Patrizia

AU - Aflalo-Rattenbach, Revital

AU - Créau, Nicole

PY - 2007

Y1 - 2007

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AB - We report the identification of a cDNA that encodes a putative protein of 94 amino acids and expected molecular weight of 10.7 kDa, the C-terminal half of which is identical to that of PEP19, a small, brain-specific protein involved in Ca++/calmodulin signaling. The novel rat-specific protein, tentatively named long PEP19 isoform (LPI), is the product of alternative splicing of the rat PCP4 gene encoding PEP19. We found that antibodies raised against the first 13 N-terminal amino acids of LPI, not present in PEP19, recognize a protein enriched in the developing rat brain.

KW - Ca++/calmodulin signaling

KW - LPI

KW - rat brain

UR - http://hdl.handle.net/10447/36893

M3 - Article

VL - 2007

SP - 501

EP - 509

JO - International Journal of Molecular Medicine

JF - International Journal of Molecular Medicine

SN - 1107-3756

ER -