TY - JOUR
T1 - Clinical Utility of Midregional Proadrenomedullin in Patients with COVID-19
AU - Scichilone, Nicola
AU - Lo Sasso, Bruna
AU - Bivona, Giulia
AU - Agnello, Luisa
AU - Barbagallo, Mario
AU - Giglio, Rosaria Vincenza
AU - Scazzone, Concetta
AU - Gambino, Caterina Maria
AU - Ciaccio, Marcello
AU - Ciaccio, Marcello
AU - Lo Sasso, Bruna
AU - Muratore, Roberto
AU - Milano, Salvatore
AU - Muratore, Roberto
AU - Milano, Salvatore
PY - 2021
Y1 - 2021
N2 - Objective: The aim of the study was to assess the role of midregional proadrenomedullin (MR-proADM) in patients with COVID-19.Methods: We included 110 patients hospitalized for COVID-19. Biochemical biomarkers, including MR-proADM, were measured at admission. The association of plasma MR-proADM levels with COVID-19 severity, defined as a requirement for mechanical ventilation or in-hospital mortality, was evaluated.Results: Patients showed increased levels of MR-proADM. In addition, MR-proADM was higher in patients who died during hospitalization than in patients who survived (median, 2.59 nmol/L; interquartile range, 2.3-2.95 vs median, 0.82 nmol/L; interquartile range, 0.57-1.03; P <.0001). Receiver operating characteristic curve analysis showed good accuracy of MR-proADM for predicting mortality. A MR-proADM value of 1.73 nmol/L was established as the best cutoff value, with 90% sensitivity and 95% specificity (P <.0001).Conclusion: We found that MR-proADM could represent a prognostic biomarker of COVID-19.
AB - Objective: The aim of the study was to assess the role of midregional proadrenomedullin (MR-proADM) in patients with COVID-19.Methods: We included 110 patients hospitalized for COVID-19. Biochemical biomarkers, including MR-proADM, were measured at admission. The association of plasma MR-proADM levels with COVID-19 severity, defined as a requirement for mechanical ventilation or in-hospital mortality, was evaluated.Results: Patients showed increased levels of MR-proADM. In addition, MR-proADM was higher in patients who died during hospitalization than in patients who survived (median, 2.59 nmol/L; interquartile range, 2.3-2.95 vs median, 0.82 nmol/L; interquartile range, 0.57-1.03; P <.0001). Receiver operating characteristic curve analysis showed good accuracy of MR-proADM for predicting mortality. A MR-proADM value of 1.73 nmol/L was established as the best cutoff value, with 90% sensitivity and 95% specificity (P <.0001).Conclusion: We found that MR-proADM could represent a prognostic biomarker of COVID-19.
UR - http://hdl.handle.net/10447/517229
UR - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8600477/
M3 - Article
SN - 0007-5027
VL - 52
SP - 493
EP - 498
JO - Laboratory Medicine
JF - Laboratory Medicine
ER -