Clinical Use of κ Free Light Chains Index as a Screening Test for Multiple Sclerosis

Luisa Agnello, Marcello Ciaccio, Giulia Bivona, Giuseppe Salemi, Bruna Lo Sasso, Concetta Scazzone, Marcello Ciaccio, Patrizia Altavilla, Francesco Meli, Emanuela Maria Pappalardo, Rosalia Caldarella, Emanuela Maria Pappalardo, Francesco Meli, Rosalia Caldarella

Risultato della ricerca: Articlepeer review

2 Citazioni (Scopus)


Objective: To assess the usefulness of the κ free light chain index(κFLCi) as a screening test to identify patients with suspected MS.Methods: The study included 56 patients with a request to test foroligoclonal bands (OCBs). OCBs were detected by isoelectric focusing,followed by immunofixation. Cerebrospinal fluid (CSF) and serum κFLCwere measured by a turbidimetric assay. Also, the κFLC index (κFLCi)was calculated.Results: CSF κFLC levels and κFLCi were significantly higher in patientswith multiple sclerosis (MS) than in patients with other neurologicaldiseases (NDs; P < .001 and P < .001, respectively). At the cutoff valueof 2.9, the κFLCi detected MS with sensitivity of 97% and specificity of65%. Overall, 92% patients with κFLCi of 2.9 or greater and who hadtested positive for OCBs were diagnosed as having MS.Conclusion: Our findings support the use of κFLCi as a screening testwhen MS is suspected, followed by OCB detection as a confirmatory test
Lingua originaleEnglish
pagine (da-a)402-407
Numero di pagine6
RivistaLaboratory Medicine
Stato di pubblicazionePublished - 2020

All Science Journal Classification (ASJC) codes

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