Clinical relevance of thymidylate syntetase expression in the signet ring cell histotype component of colorectal carcinoma

Federico Aragona, Anna Calascibetta, Daniela Cabibi, Rosario Sanguedolce, Aragona, Campione, Dardanoni, Calascibetta, Rosario Sanguedolce, Cabibi, Barresi, Rausa, Elisabetta Barresi, Luciano Rausa, Maria Campione

Risultato della ricerca: Articlepeer review

9 Citazioni (Scopus)

Abstract

Thymidylate Synthase (TS) is the key enzyme for DNA synthesis pathways and is inhibited by 5-fluorouracil (5FU). The aim of this work was to study TS expression and the proliferation rate in the different histological types of colorectal carcinoma (CRC). 50 patients with CRC were included in this study and evaluated immunohistochemically using the monoclonal antibodies, TS106 and Ki67. 20 tumours were of the intestinal type, 15 cases were signet ring cell carcinoma (SRCCs) and 15 cases were "mixed-type", with at least two different histological components. Intestinal and mucinous histotypes were positive for TS and Ki67, while "signet ring cell" samples were negative or showed only weak and focal positivity for both the TS and Ki67 antibodies. Our results show that signet ring cells (that are also often present in intestinal and mucinous carcinomas), are in the post-mitotic phase of the cell cycle and show a low proliferation index and TS expression. As TS is the key enzyme for DNA synthesis pathways and is inhibited by 5-fluorouracil (5FU), we can hypothesise that TS expression levels in the different histotypes of CRC could affect the potential responsiveness of these tumours to fluoropyrimidine chemotherapy, with a low efficacy being expected in signet ring cell areas.
Lingua originaleEnglish
pagine (da-a)2845-2850
Numero di pagine6
RivistaEuropean Journal of Cancer
Volume40
Stato di pubblicazionePublished - 2004

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

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