Clinical findings of Takotsubo cardiomyopathy: results from a multicenter international study

Gaspare Barbaro, Salvatore Novo, Lombardi, Giovanni Fazio, Giuseppe Barbaro, Salvatore Azzarelli, Tomas Palecek, Giuseppe Barbaro, Yoshiro J. Akashi, Caterina Pizzuto, Gabriele Di Gesaro, Giovanni Fazio

    Risultato della ricerca: Article

    23 Citazioni (Scopus)

    Abstract

    BACKGROUND:Takotsubo cardiomyopathy consists of reversible systolic left ventricular apical ballooning associated with chest pain. Electrocardiographic abnormalities and the minimal rise of serum cardiac markers are similar to those in acute myocardial infarction, but without evidence of myocardial ischemia or injury. To date, many reports concerning this kind of acute reversible heart failure have been published, but the information available about the management of affected patients is scarce and the clinical data are incomplete.AIMS:In the present study, we report a collection of 40 patients who were affected by Takotsubo cardiomyopathy obtained in a multicentric international study, aiming to investigate the origins, and the clinical and instrumental patterns, and to establish the best diagnostic criteria for this syndrome.METHODS AND RESULTS:In the analysed group, the mean age was 68 years, of whom 85% were women. On admission to hospital, 68% of patients reported chest pain. An electrocardiogram (ECG) showed anterolateral (34%) or anterior (36%) ST segment elevation. The ECG demonstrated hyperkinesis of the basal segments with a severe hypokinesis of the other segments. Mean ejection fraction was 42.53%. Three patients died within the first 24 h from acute heart failure. The remaining 37 patients showed a complete resolution of symptoms and a complete normalization of the kinesis deficiency. Sixteen patients underwent myocardial scintigraphy, nine cases underwent myocardial biopsy and two patients received an ergonovine test.CONCLUSION:Our results demonstrate a good course of Takotsubo cardiomioathy, after the initial phase. An echocardiogram is an important tool for improving the diagnosis.
    Lingua originaleEnglish
    pagine (da-a)239-244
    Numero di pagine6
    RivistaJournal of Cardiovascular Medicine
    Volume9
    Stato di pubblicazionePublished - 2008

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    Takotsubo Cardiomyopathy
    Multicenter Studies
    Chest Pain
    Electrocardiography
    Kinesis
    Heart Failure
    Ergonovine
    Hyperkinesis
    Myocardial Perfusion Imaging
    Myocardial Ischemia
    Age Groups
    Biomarkers
    Myocardial Infarction
    Biopsy
    Wounds and Injuries

    All Science Journal Classification (ASJC) codes

    • Cardiology and Cardiovascular Medicine

    Cita questo

    Clinical findings of Takotsubo cardiomyopathy: results from a multicenter international study. / Barbaro, Gaspare; Novo, Salvatore; Lombardi; Fazio, Giovanni; Barbaro, Giuseppe; Azzarelli, Salvatore; Palecek, Tomas; Barbaro, Giuseppe; Akashi, Yoshiro J.; Pizzuto, Caterina; Di Gesaro, Gabriele; Fazio, Giovanni.

    In: Journal of Cardiovascular Medicine, Vol. 9, 2008, pag. 239-244.

    Risultato della ricerca: Article

    Barbaro, G, Novo, S, Lombardi, Fazio, G, Barbaro, G, Azzarelli, S, Palecek, T, Barbaro, G, Akashi, YJ, Pizzuto, C, Di Gesaro, G & Fazio, G 2008, 'Clinical findings of Takotsubo cardiomyopathy: results from a multicenter international study', Journal of Cardiovascular Medicine, vol. 9, pagg. 239-244.
    Barbaro G, Novo S, Lombardi, Fazio G, Barbaro G, Azzarelli S e altri. Clinical findings of Takotsubo cardiomyopathy: results from a multicenter international study. Journal of Cardiovascular Medicine. 2008;9:239-244.
    Barbaro, Gaspare ; Novo, Salvatore ; Lombardi ; Fazio, Giovanni ; Barbaro, Giuseppe ; Azzarelli, Salvatore ; Palecek, Tomas ; Barbaro, Giuseppe ; Akashi, Yoshiro J. ; Pizzuto, Caterina ; Di Gesaro, Gabriele ; Fazio, Giovanni. / Clinical findings of Takotsubo cardiomyopathy: results from a multicenter international study. In: Journal of Cardiovascular Medicine. 2008 ; Vol. 9. pagg. 239-244.
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    title = "Clinical findings of Takotsubo cardiomyopathy: results from a multicenter international study",
    abstract = "BACKGROUND:Takotsubo cardiomyopathy consists of reversible systolic left ventricular apical ballooning associated with chest pain. Electrocardiographic abnormalities and the minimal rise of serum cardiac markers are similar to those in acute myocardial infarction, but without evidence of myocardial ischemia or injury. To date, many reports concerning this kind of acute reversible heart failure have been published, but the information available about the management of affected patients is scarce and the clinical data are incomplete.AIMS:In the present study, we report a collection of 40 patients who were affected by Takotsubo cardiomyopathy obtained in a multicentric international study, aiming to investigate the origins, and the clinical and instrumental patterns, and to establish the best diagnostic criteria for this syndrome.METHODS AND RESULTS:In the analysed group, the mean age was 68 years, of whom 85{\%} were women. On admission to hospital, 68{\%} of patients reported chest pain. An electrocardiogram (ECG) showed anterolateral (34{\%}) or anterior (36{\%}) ST segment elevation. The ECG demonstrated hyperkinesis of the basal segments with a severe hypokinesis of the other segments. Mean ejection fraction was 42.53{\%}. Three patients died within the first 24 h from acute heart failure. The remaining 37 patients showed a complete resolution of symptoms and a complete normalization of the kinesis deficiency. Sixteen patients underwent myocardial scintigraphy, nine cases underwent myocardial biopsy and two patients received an ergonovine test.CONCLUSION:Our results demonstrate a good course of Takotsubo cardiomioathy, after the initial phase. An echocardiogram is an important tool for improving the diagnosis.",
    author = "Gaspare Barbaro and Salvatore Novo and Lombardi and Giovanni Fazio and Giuseppe Barbaro and Salvatore Azzarelli and Tomas Palecek and Giuseppe Barbaro and Akashi, {Yoshiro J.} and Caterina Pizzuto and {Di Gesaro}, Gabriele and Giovanni Fazio",
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    T1 - Clinical findings of Takotsubo cardiomyopathy: results from a multicenter international study

    AU - Barbaro, Gaspare

    AU - Novo, Salvatore

    AU - Lombardi, null

    AU - Fazio, Giovanni

    AU - Barbaro, Giuseppe

    AU - Azzarelli, Salvatore

    AU - Palecek, Tomas

    AU - Barbaro, Giuseppe

    AU - Akashi, Yoshiro J.

    AU - Pizzuto, Caterina

    AU - Di Gesaro, Gabriele

    AU - Fazio, Giovanni

    PY - 2008

    Y1 - 2008

    N2 - BACKGROUND:Takotsubo cardiomyopathy consists of reversible systolic left ventricular apical ballooning associated with chest pain. Electrocardiographic abnormalities and the minimal rise of serum cardiac markers are similar to those in acute myocardial infarction, but without evidence of myocardial ischemia or injury. To date, many reports concerning this kind of acute reversible heart failure have been published, but the information available about the management of affected patients is scarce and the clinical data are incomplete.AIMS:In the present study, we report a collection of 40 patients who were affected by Takotsubo cardiomyopathy obtained in a multicentric international study, aiming to investigate the origins, and the clinical and instrumental patterns, and to establish the best diagnostic criteria for this syndrome.METHODS AND RESULTS:In the analysed group, the mean age was 68 years, of whom 85% were women. On admission to hospital, 68% of patients reported chest pain. An electrocardiogram (ECG) showed anterolateral (34%) or anterior (36%) ST segment elevation. The ECG demonstrated hyperkinesis of the basal segments with a severe hypokinesis of the other segments. Mean ejection fraction was 42.53%. Three patients died within the first 24 h from acute heart failure. The remaining 37 patients showed a complete resolution of symptoms and a complete normalization of the kinesis deficiency. Sixteen patients underwent myocardial scintigraphy, nine cases underwent myocardial biopsy and two patients received an ergonovine test.CONCLUSION:Our results demonstrate a good course of Takotsubo cardiomioathy, after the initial phase. An echocardiogram is an important tool for improving the diagnosis.

    AB - BACKGROUND:Takotsubo cardiomyopathy consists of reversible systolic left ventricular apical ballooning associated with chest pain. Electrocardiographic abnormalities and the minimal rise of serum cardiac markers are similar to those in acute myocardial infarction, but without evidence of myocardial ischemia or injury. To date, many reports concerning this kind of acute reversible heart failure have been published, but the information available about the management of affected patients is scarce and the clinical data are incomplete.AIMS:In the present study, we report a collection of 40 patients who were affected by Takotsubo cardiomyopathy obtained in a multicentric international study, aiming to investigate the origins, and the clinical and instrumental patterns, and to establish the best diagnostic criteria for this syndrome.METHODS AND RESULTS:In the analysed group, the mean age was 68 years, of whom 85% were women. On admission to hospital, 68% of patients reported chest pain. An electrocardiogram (ECG) showed anterolateral (34%) or anterior (36%) ST segment elevation. The ECG demonstrated hyperkinesis of the basal segments with a severe hypokinesis of the other segments. Mean ejection fraction was 42.53%. Three patients died within the first 24 h from acute heart failure. The remaining 37 patients showed a complete resolution of symptoms and a complete normalization of the kinesis deficiency. Sixteen patients underwent myocardial scintigraphy, nine cases underwent myocardial biopsy and two patients received an ergonovine test.CONCLUSION:Our results demonstrate a good course of Takotsubo cardiomioathy, after the initial phase. An echocardiogram is an important tool for improving the diagnosis.

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    JO - Journal of Cardiovascular Medicine

    JF - Journal of Cardiovascular Medicine

    SN - 1558-2027

    ER -

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