Abstract
| Lingua originale | English |
|---|---|
| pagine (da-a) | 287-291 |
| Numero di pagine | 5 |
| Rivista | ANNALI DELL'ISTITUTO SUPERIORE DI SANITÀ |
| Volume | 48 |
| Stato di pubblicazione | Published - 2012 |
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All Science Journal Classification (ASJC) codes
- Public Health, Environmental and Occupational Health
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Clinical features and lifestyle of patients with amyotrophic lateral sclerosis in Campania: brief overview of an Italian database. / Savettieri, Giovanni; Trojsi, Francesca; Sagnelli, Anna; Laiola, Anna; Daniele, Luca; Izzo, Francesco; Monsurrò, Maria Rosaria; Costanzo, Alfonso Di; Vanacore, Nicola; Piccirillo, Giovanni; Costanzo, Alfonso Di; Tedeschi, Gioacchino.
In: ANNALI DELL'ISTITUTO SUPERIORE DI SANITÀ, Vol. 48, 2012, pag. 287-291.Risultato della ricerca: Article
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TY - JOUR
T1 - Clinical features and lifestyle of patients with amyotrophic lateral sclerosis in Campania: brief overview of an Italian database.
AU - Savettieri, Giovanni
AU - Trojsi, Francesca
AU - Sagnelli, Anna
AU - Laiola, Anna
AU - Daniele, Luca
AU - Izzo, Francesco
AU - Monsurrò, Maria Rosaria
AU - Costanzo, Alfonso Di
AU - Vanacore, Nicola
AU - Piccirillo, Giovanni
AU - Costanzo, Alfonso Di
AU - Tedeschi, Gioacchino
PY - 2012
Y1 - 2012
N2 - Abstract. Background. Physical activity and occupational exposures appeared to play a relevant rolein pathogenesis of amyotrophic lateral sclerosis (ALS), a neurodegenerative disease of unknownorigin. Materials and methods. We aimed to make an overview of the clinical characteristics and lifestyle(occupation and sport) of a population of 395 patients with ALS from Campania, in southernItaly. Results. ALS onset resulted anticipated of about 11 years in industry workers, whilst the morefrequent site of onset among farmers was upper limbs. Compared to non-athletes, athletes, particularlysoccer players, showed a 7 years anticipation of ALS onset, with higher mortality after 5 years.Discussion and conclusions. We suggest that subjects genetically prone to abnormal response to hypoxiaduring strenuous physical activity or exposed to neurotoxic agents, such as athletes, farmers orindustry workers, might present increased risk to develop ALS. Future case-control and follow-upstudies on our population should be implemented to deepen the present results.
AB - Abstract. Background. Physical activity and occupational exposures appeared to play a relevant rolein pathogenesis of amyotrophic lateral sclerosis (ALS), a neurodegenerative disease of unknownorigin. Materials and methods. We aimed to make an overview of the clinical characteristics and lifestyle(occupation and sport) of a population of 395 patients with ALS from Campania, in southernItaly. Results. ALS onset resulted anticipated of about 11 years in industry workers, whilst the morefrequent site of onset among farmers was upper limbs. Compared to non-athletes, athletes, particularlysoccer players, showed a 7 years anticipation of ALS onset, with higher mortality after 5 years.Discussion and conclusions. We suggest that subjects genetically prone to abnormal response to hypoxiaduring strenuous physical activity or exposed to neurotoxic agents, such as athletes, farmers orindustry workers, might present increased risk to develop ALS. Future case-control and follow-upstudies on our population should be implemented to deepen the present results.
KW - Amyotrophic lateral sclerosis
KW - clinical database
KW - motor neuron diseases
KW - occupational exposure.
UR - http://hdl.handle.net/10447/73190
M3 - Article
VL - 48
SP - 287
EP - 291
JO - Annali dell'Istituto Superiore di Sanita
JF - Annali dell'Istituto Superiore di Sanita
SN - 0021-2571
ER -