Clinical features and lifestyle of patients with amyotrophic lateral sclerosis in Campania: brief overview of an Italian database.

Giovanni Savettieri, Francesca Trojsi, Anna Sagnelli, Anna Laiola, Luca Daniele, Francesco Izzo, Maria Rosaria Monsurrò, Alfonso Di Costanzo, Nicola Vanacore, Giovanni Piccirillo, Alfonso Di Costanzo, Gioacchino Tedeschi

    Risultato della ricerca: Article

    6 Citazioni (Scopus)

    Abstract

    Abstract. Background. Physical activity and occupational exposures appeared to play a relevant rolein pathogenesis of amyotrophic lateral sclerosis (ALS), a neurodegenerative disease of unknownorigin. Materials and methods. We aimed to make an overview of the clinical characteristics and lifestyle(occupation and sport) of a population of 395 patients with ALS from Campania, in southernItaly. Results. ALS onset resulted anticipated of about 11 years in industry workers, whilst the morefrequent site of onset among farmers was upper limbs. Compared to non-athletes, athletes, particularlysoccer players, showed a 7 years anticipation of ALS onset, with higher mortality after 5 years.Discussion and conclusions. We suggest that subjects genetically prone to abnormal response to hypoxiaduring strenuous physical activity or exposed to neurotoxic agents, such as athletes, farmers orindustry workers, might present increased risk to develop ALS. Future case-control and follow-upstudies on our population should be implemented to deepen the present results.
    Lingua originaleEnglish
    pagine (da-a)287-291
    Numero di pagine5
    RivistaANNALI DELL'ISTITUTO SUPERIORE DI SANITÀ
    Volume48
    Stato di pubblicazionePublished - 2012

    Fingerprint

    Amyotrophic Lateral Sclerosis
    Life Style
    Databases
    Athletes
    Exercise
    Occupational Exposure
    Occupations
    Upper Extremity
    Neurodegenerative Diseases
    Population
    Sports
    Industry
    Mortality
    Farmers

    All Science Journal Classification (ASJC) codes

    • Public Health, Environmental and Occupational Health

    Cita questo

    Clinical features and lifestyle of patients with amyotrophic lateral sclerosis in Campania: brief overview of an Italian database. / Savettieri, Giovanni; Trojsi, Francesca; Sagnelli, Anna; Laiola, Anna; Daniele, Luca; Izzo, Francesco; Monsurrò, Maria Rosaria; Costanzo, Alfonso Di; Vanacore, Nicola; Piccirillo, Giovanni; Costanzo, Alfonso Di; Tedeschi, Gioacchino.

    In: ANNALI DELL'ISTITUTO SUPERIORE DI SANITÀ, Vol. 48, 2012, pag. 287-291.

    Risultato della ricerca: Article

    Savettieri, G, Trojsi, F, Sagnelli, A, Laiola, A, Daniele, L, Izzo, F, Monsurrò, MR, Costanzo, AD, Vanacore, N, Piccirillo, G, Costanzo, AD & Tedeschi, G 2012, 'Clinical features and lifestyle of patients with amyotrophic lateral sclerosis in Campania: brief overview of an Italian database.', ANNALI DELL'ISTITUTO SUPERIORE DI SANITÀ, vol. 48, pagg. 287-291.
    Savettieri, Giovanni ; Trojsi, Francesca ; Sagnelli, Anna ; Laiola, Anna ; Daniele, Luca ; Izzo, Francesco ; Monsurrò, Maria Rosaria ; Costanzo, Alfonso Di ; Vanacore, Nicola ; Piccirillo, Giovanni ; Costanzo, Alfonso Di ; Tedeschi, Gioacchino. / Clinical features and lifestyle of patients with amyotrophic lateral sclerosis in Campania: brief overview of an Italian database. In: ANNALI DELL'ISTITUTO SUPERIORE DI SANITÀ. 2012 ; Vol. 48. pagg. 287-291.
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    title = "Clinical features and lifestyle of patients with amyotrophic lateral sclerosis in Campania: brief overview of an Italian database.",
    abstract = "Abstract. Background. Physical activity and occupational exposures appeared to play a relevant rolein pathogenesis of amyotrophic lateral sclerosis (ALS), a neurodegenerative disease of unknownorigin. Materials and methods. We aimed to make an overview of the clinical characteristics and lifestyle(occupation and sport) of a population of 395 patients with ALS from Campania, in southernItaly. Results. ALS onset resulted anticipated of about 11 years in industry workers, whilst the morefrequent site of onset among farmers was upper limbs. Compared to non-athletes, athletes, particularlysoccer players, showed a 7 years anticipation of ALS onset, with higher mortality after 5 years.Discussion and conclusions. We suggest that subjects genetically prone to abnormal response to hypoxiaduring strenuous physical activity or exposed to neurotoxic agents, such as athletes, farmers orindustry workers, might present increased risk to develop ALS. Future case-control and follow-upstudies on our population should be implemented to deepen the present results.",
    keywords = "Amyotrophic lateral sclerosis, clinical database, motor neuron diseases, occupational exposure.",
    author = "Giovanni Savettieri and Francesca Trojsi and Anna Sagnelli and Anna Laiola and Luca Daniele and Francesco Izzo and Monsurr{\`o}, {Maria Rosaria} and Costanzo, {Alfonso Di} and Nicola Vanacore and Giovanni Piccirillo and Costanzo, {Alfonso Di} and Gioacchino Tedeschi",
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    TY - JOUR

    T1 - Clinical features and lifestyle of patients with amyotrophic lateral sclerosis in Campania: brief overview of an Italian database.

    AU - Savettieri, Giovanni

    AU - Trojsi, Francesca

    AU - Sagnelli, Anna

    AU - Laiola, Anna

    AU - Daniele, Luca

    AU - Izzo, Francesco

    AU - Monsurrò, Maria Rosaria

    AU - Costanzo, Alfonso Di

    AU - Vanacore, Nicola

    AU - Piccirillo, Giovanni

    AU - Costanzo, Alfonso Di

    AU - Tedeschi, Gioacchino

    PY - 2012

    Y1 - 2012

    N2 - Abstract. Background. Physical activity and occupational exposures appeared to play a relevant rolein pathogenesis of amyotrophic lateral sclerosis (ALS), a neurodegenerative disease of unknownorigin. Materials and methods. We aimed to make an overview of the clinical characteristics and lifestyle(occupation and sport) of a population of 395 patients with ALS from Campania, in southernItaly. Results. ALS onset resulted anticipated of about 11 years in industry workers, whilst the morefrequent site of onset among farmers was upper limbs. Compared to non-athletes, athletes, particularlysoccer players, showed a 7 years anticipation of ALS onset, with higher mortality after 5 years.Discussion and conclusions. We suggest that subjects genetically prone to abnormal response to hypoxiaduring strenuous physical activity or exposed to neurotoxic agents, such as athletes, farmers orindustry workers, might present increased risk to develop ALS. Future case-control and follow-upstudies on our population should be implemented to deepen the present results.

    AB - Abstract. Background. Physical activity and occupational exposures appeared to play a relevant rolein pathogenesis of amyotrophic lateral sclerosis (ALS), a neurodegenerative disease of unknownorigin. Materials and methods. We aimed to make an overview of the clinical characteristics and lifestyle(occupation and sport) of a population of 395 patients with ALS from Campania, in southernItaly. Results. ALS onset resulted anticipated of about 11 years in industry workers, whilst the morefrequent site of onset among farmers was upper limbs. Compared to non-athletes, athletes, particularlysoccer players, showed a 7 years anticipation of ALS onset, with higher mortality after 5 years.Discussion and conclusions. We suggest that subjects genetically prone to abnormal response to hypoxiaduring strenuous physical activity or exposed to neurotoxic agents, such as athletes, farmers orindustry workers, might present increased risk to develop ALS. Future case-control and follow-upstudies on our population should be implemented to deepen the present results.

    KW - Amyotrophic lateral sclerosis

    KW - clinical database

    KW - motor neuron diseases

    KW - occupational exposure.

    UR - http://hdl.handle.net/10447/73190

    M3 - Article

    VL - 48

    SP - 287

    EP - 291

    JO - Annali dell'Istituto Superiore di Sanita

    JF - Annali dell'Istituto Superiore di Sanita

    SN - 0021-2571

    ER -