Clinical course of ulcerative colitis

Mario Cottone, Giuseppe Civitavecchia, Daniela Scimeca, Ambrogio Orlando, Mario Cottone, Civitavecchia, Filippo Mocciaro, Scimeca, Giovanni Perricone

Risultato della ricerca: Article

25 Citazioni (Scopus)

Abstract

. Dig Liver Dis. 2008 Jul;40 Suppl 2:S247-52. Clinical course of ulcerative colitis. Cottone M, Scimeca D, Mocciaro F, Civitavecchia G, Perricone G, Orlando A. Department of Medicine, Pneumology and Nutrition Clinic, V. Cervello Hospital, University of Palermo, Palermo, Italy. AIM: To provide a review of studies on prognosis in ulcerative colitis by reviewing the relevant population-based cohort studies. On the basis of incidence and population studies, ulcerative colitis has a favourable clinical course, with good quality of life, a chronic course characterized by at least one relapse, and a surgery rate of 30% after 10 years from diagnosis. Patients affected by severe ulcerative colitis have a higher risk of colectomy, and some clinical variables may predict the disease's clinical course. Most patients respond to steroids and only a low percentage become dependent, or non-responders to steroids. Patients who have a long-lasting ulcerative colitis (>10 years) or are affected by an extensive disease have an increased risk of developing colorectal cancer, while those treated with immunosuppressants for long period of time may have an increased risk of developing lymphomas. Data on mortality in ulcerative colitis patients are not homogeneous, but if a real risk exists it is in patients with extensive or severe disease. The evidence that patients with severe ulcerative colitis are often non-smokers may explain why in one study the mortality rate was lower.
Lingua originaleEnglish
pagine (da-a)247-252
RivistaDigestive Diseases and Sciences
Volume40
Stato di pubblicazionePublished - 2008

Fingerprint

Ulcerative Colitis
Steroids
Pulmonary Medicine
Mortality
Colectomy
Immunosuppressive Agents
Italy
Population
Colorectal Neoplasms
Lymphoma
Cohort Studies
Quality of Life
Medicine
Recurrence
Liver

All Science Journal Classification (ASJC) codes

  • Hepatology
  • Gastroenterology

Cita questo

Cottone, M., Civitavecchia, G., Scimeca, D., Orlando, A., Cottone, M., Civitavecchia, ... Perricone, G. (2008). Clinical course of ulcerative colitis. Digestive Diseases and Sciences, 40, 247-252.

Clinical course of ulcerative colitis. / Cottone, Mario; Civitavecchia, Giuseppe; Scimeca, Daniela; Orlando, Ambrogio; Cottone, Mario; Civitavecchia; Mocciaro, Filippo; Scimeca; Perricone, Giovanni.

In: Digestive Diseases and Sciences, Vol. 40, 2008, pag. 247-252.

Risultato della ricerca: Article

Cottone, M, Civitavecchia, G, Scimeca, D, Orlando, A, Cottone, M, Civitavecchia, Mocciaro, F, Scimeca & Perricone, G 2008, 'Clinical course of ulcerative colitis', Digestive Diseases and Sciences, vol. 40, pagg. 247-252.
Cottone, Mario ; Civitavecchia, Giuseppe ; Scimeca, Daniela ; Orlando, Ambrogio ; Cottone, Mario ; Civitavecchia ; Mocciaro, Filippo ; Scimeca ; Perricone, Giovanni. / Clinical course of ulcerative colitis. In: Digestive Diseases and Sciences. 2008 ; Vol. 40. pagg. 247-252.
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AB - . Dig Liver Dis. 2008 Jul;40 Suppl 2:S247-52. Clinical course of ulcerative colitis. Cottone M, Scimeca D, Mocciaro F, Civitavecchia G, Perricone G, Orlando A. Department of Medicine, Pneumology and Nutrition Clinic, V. Cervello Hospital, University of Palermo, Palermo, Italy. AIM: To provide a review of studies on prognosis in ulcerative colitis by reviewing the relevant population-based cohort studies. On the basis of incidence and population studies, ulcerative colitis has a favourable clinical course, with good quality of life, a chronic course characterized by at least one relapse, and a surgery rate of 30% after 10 years from diagnosis. Patients affected by severe ulcerative colitis have a higher risk of colectomy, and some clinical variables may predict the disease's clinical course. Most patients respond to steroids and only a low percentage become dependent, or non-responders to steroids. Patients who have a long-lasting ulcerative colitis (>10 years) or are affected by an extensive disease have an increased risk of developing colorectal cancer, while those treated with immunosuppressants for long period of time may have an increased risk of developing lymphomas. Data on mortality in ulcerative colitis patients are not homogeneous, but if a real risk exists it is in patients with extensive or severe disease. The evidence that patients with severe ulcerative colitis are often non-smokers may explain why in one study the mortality rate was lower.

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