Citrus limon-derived nanovesicles inhibit cancer cell proliferation and suppress CML xenograft growth by inducing TRAIL-mediated cell death

Maria Antonietta Di Bella, Flores Naselli, Alessia Lo Dico, Francesca Monteleone, Giovanni Zito, Giacomo De Leo, Laura Saieva, Simona Fontana, Stefania Raimondo, Riccardo Alessandro, Mauro Manno, Giovanni Zito, Mauro Manno

Risultato della ricerca: Article

43 Citazioni (Scopus)

Abstract

Nanosized vesicles are considered key players in cell to cell communication, thus influencing physiological and pathological processes, including cancer. Nanovesicles have also been found in edible-plants and have shown therapeutic activity in inflammatory bowel diseases; however information on their role in affecting cancer progression is missing.Our study identify for the first time a fraction of vesicles from lemon juice (Citrus limon L.), obtained as a result of different ultracentrifugation, with density ranging from 1,15 to 1,19 g/ml and specific proteomic profile. By using an in vitro approach, we show that isolated nanovesicles inhibit cancer cell proliferation in different tumor cell lines, by activating a TRAIL-mediated apoptotic cell death. Furthermore, we demonstrate that lemon nanovesicles suppress CML tumor growth in vivo by specifically reaching tumor site and by activating TRAIL-mediated apoptotic cell processes. Overall, this study suggests the possible use of plant-edible nanovesicles as a feasible approach in cancer treatment.
Lingua originaleEnglish
Numero di pagine10
RivistaOncotarget
Volume6
Stato di pubblicazionePublished - 2015

Fingerprint

Citrus
Heterografts
Cell Death
Cell Proliferation
Growth
Neoplasms
Edible Plants
Physiological Phenomena
Ultracentrifugation
Pathologic Processes
Tumor Cell Line
Inflammatory Bowel Diseases
Cell Communication
Proteomics

All Science Journal Classification (ASJC) codes

  • Oncology

Cita questo

Citrus limon-derived nanovesicles inhibit cancer cell proliferation and suppress CML xenograft growth by inducing TRAIL-mediated cell death. / Di Bella, Maria Antonietta; Naselli, Flores; Lo Dico, Alessia; Monteleone, Francesca; Zito, Giovanni; De Leo, Giacomo; Saieva, Laura; Fontana, Simona; Raimondo, Stefania; Alessandro, Riccardo; Manno, Mauro; Zito, Giovanni; Manno, Mauro.

In: Oncotarget, Vol. 6, 2015.

Risultato della ricerca: Article

Di Bella, MA, Naselli, F, Lo Dico, A, Monteleone, F, Zito, G, De Leo, G, Saieva, L, Fontana, S, Raimondo, S, Alessandro, R, Manno, M, Zito, G & Manno, M 2015, 'Citrus limon-derived nanovesicles inhibit cancer cell proliferation and suppress CML xenograft growth by inducing TRAIL-mediated cell death', Oncotarget, vol. 6.
Di Bella MA, Naselli F, Lo Dico A, Monteleone F, Zito G, De Leo G e altri. Citrus limon-derived nanovesicles inhibit cancer cell proliferation and suppress CML xenograft growth by inducing TRAIL-mediated cell death. Oncotarget. 2015;6.
Di Bella, Maria Antonietta ; Naselli, Flores ; Lo Dico, Alessia ; Monteleone, Francesca ; Zito, Giovanni ; De Leo, Giacomo ; Saieva, Laura ; Fontana, Simona ; Raimondo, Stefania ; Alessandro, Riccardo ; Manno, Mauro ; Zito, Giovanni ; Manno, Mauro. / Citrus limon-derived nanovesicles inhibit cancer cell proliferation and suppress CML xenograft growth by inducing TRAIL-mediated cell death. In: Oncotarget. 2015 ; Vol. 6.
@article{72c1eaab3d394ba7927b3dcd3fe90bc0,
title = "Citrus limon-derived nanovesicles inhibit cancer cell proliferation and suppress CML xenograft growth by inducing TRAIL-mediated cell death",
abstract = "Nanosized vesicles are considered key players in cell to cell communication, thus influencing physiological and pathological processes, including cancer. Nanovesicles have also been found in edible-plants and have shown therapeutic activity in inflammatory bowel diseases; however information on their role in affecting cancer progression is missing.Our study identify for the first time a fraction of vesicles from lemon juice (Citrus limon L.), obtained as a result of different ultracentrifugation, with density ranging from 1,15 to 1,19 g/ml and specific proteomic profile. By using an in vitro approach, we show that isolated nanovesicles inhibit cancer cell proliferation in different tumor cell lines, by activating a TRAIL-mediated apoptotic cell death. Furthermore, we demonstrate that lemon nanovesicles suppress CML tumor growth in vivo by specifically reaching tumor site and by activating TRAIL-mediated apoptotic cell processes. Overall, this study suggests the possible use of plant-edible nanovesicles as a feasible approach in cancer treatment.",
keywords = "Citrus limon L., TRAIL-mediated cell death, cancer, exosome-like nanovesicles",
author = "{Di Bella}, {Maria Antonietta} and Flores Naselli and {Lo Dico}, Alessia and Francesca Monteleone and Giovanni Zito and {De Leo}, Giacomo and Laura Saieva and Simona Fontana and Stefania Raimondo and Riccardo Alessandro and Mauro Manno and Giovanni Zito and Mauro Manno",
year = "2015",
language = "English",
volume = "6",
journal = "Oncotarget",
issn = "1949-2553",
publisher = "Impact Journals",

}

TY - JOUR

T1 - Citrus limon-derived nanovesicles inhibit cancer cell proliferation and suppress CML xenograft growth by inducing TRAIL-mediated cell death

AU - Di Bella, Maria Antonietta

AU - Naselli, Flores

AU - Lo Dico, Alessia

AU - Monteleone, Francesca

AU - Zito, Giovanni

AU - De Leo, Giacomo

AU - Saieva, Laura

AU - Fontana, Simona

AU - Raimondo, Stefania

AU - Alessandro, Riccardo

AU - Manno, Mauro

AU - Zito, Giovanni

AU - Manno, Mauro

PY - 2015

Y1 - 2015

N2 - Nanosized vesicles are considered key players in cell to cell communication, thus influencing physiological and pathological processes, including cancer. Nanovesicles have also been found in edible-plants and have shown therapeutic activity in inflammatory bowel diseases; however information on their role in affecting cancer progression is missing.Our study identify for the first time a fraction of vesicles from lemon juice (Citrus limon L.), obtained as a result of different ultracentrifugation, with density ranging from 1,15 to 1,19 g/ml and specific proteomic profile. By using an in vitro approach, we show that isolated nanovesicles inhibit cancer cell proliferation in different tumor cell lines, by activating a TRAIL-mediated apoptotic cell death. Furthermore, we demonstrate that lemon nanovesicles suppress CML tumor growth in vivo by specifically reaching tumor site and by activating TRAIL-mediated apoptotic cell processes. Overall, this study suggests the possible use of plant-edible nanovesicles as a feasible approach in cancer treatment.

AB - Nanosized vesicles are considered key players in cell to cell communication, thus influencing physiological and pathological processes, including cancer. Nanovesicles have also been found in edible-plants and have shown therapeutic activity in inflammatory bowel diseases; however information on their role in affecting cancer progression is missing.Our study identify for the first time a fraction of vesicles from lemon juice (Citrus limon L.), obtained as a result of different ultracentrifugation, with density ranging from 1,15 to 1,19 g/ml and specific proteomic profile. By using an in vitro approach, we show that isolated nanovesicles inhibit cancer cell proliferation in different tumor cell lines, by activating a TRAIL-mediated apoptotic cell death. Furthermore, we demonstrate that lemon nanovesicles suppress CML tumor growth in vivo by specifically reaching tumor site and by activating TRAIL-mediated apoptotic cell processes. Overall, this study suggests the possible use of plant-edible nanovesicles as a feasible approach in cancer treatment.

KW - Citrus limon L.

KW - TRAIL-mediated cell death

KW - cancer

KW - exosome-like nanovesicles

UR - http://hdl.handle.net/10447/136552

M3 - Article

VL - 6

JO - Oncotarget

JF - Oncotarget

SN - 1949-2553

ER -

Accesso al documento