Abstract

Nanosized vesicles are considered key players in cell to cell communication, thus influencing physiological and pathological processes, including cancer. Nanovesicles have also been found in edible-plants and have shown therapeutic activity in inflammatory bowel diseases; however information on their role in affecting cancer progression is missing.Our study identify for the first time a fraction of vesicles from lemon juice (Citrus limon L.), obtained as a result of different ultracentrifugation, with density ranging from 1,15 to 1,19 g/ml and specific proteomic profile. By using an in vitro approach, we show that isolated nanovesicles inhibit cancer cell proliferation in different tumor cell lines, by activating a TRAIL-mediated apoptotic cell death. Furthermore, we demonstrate that lemon nanovesicles suppress CML tumor growth in vivo by specifically reaching tumor site and by activating TRAIL-mediated apoptotic cell processes. Overall, this study suggests the possible use of plant-edible nanovesicles as a feasible approach in cancer treatment.
Lingua originaleEnglish
Numero di pagine10
RivistaDefault journal
Volume6
Stato di pubblicazionePublished - 2015

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Citrus
Heterografts
Cell Death
Cell Proliferation
Growth
Neoplasms
Edible Plants
Physiological Phenomena
Ultracentrifugation
Pathologic Processes
Tumor Cell Line
Inflammatory Bowel Diseases
Cell Communication
Proteomics

All Science Journal Classification (ASJC) codes

  • Oncology

Cita questo

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title = "Citrus limon-derived nanovesicles inhibit cancer cell proliferation and suppress CML xenograft growth by inducing TRAIL-mediated cell death",
abstract = "Nanosized vesicles are considered key players in cell to cell communication, thus influencing physiological and pathological processes, including cancer. Nanovesicles have also been found in edible-plants and have shown therapeutic activity in inflammatory bowel diseases; however information on their role in affecting cancer progression is missing.Our study identify for the first time a fraction of vesicles from lemon juice (Citrus limon L.), obtained as a result of different ultracentrifugation, with density ranging from 1,15 to 1,19 g/ml and specific proteomic profile. By using an in vitro approach, we show that isolated nanovesicles inhibit cancer cell proliferation in different tumor cell lines, by activating a TRAIL-mediated apoptotic cell death. Furthermore, we demonstrate that lemon nanovesicles suppress CML tumor growth in vivo by specifically reaching tumor site and by activating TRAIL-mediated apoptotic cell processes. Overall, this study suggests the possible use of plant-edible nanovesicles as a feasible approach in cancer treatment.",
keywords = "Citrus limon L., TRAIL-mediated cell death, cancer, exosome-like nanovesicles",
author = "Simona Fontana and Stefania Raimondo and {Di Bella}, {Maria Antonietta} and Riccardo Alessandro and Flores Naselli and {Lo Dico}, Alessia and Francesca Monteleone and Giovanni Zito and Laura Saieva and {De Leo}, Giacomo and Mauro Manno and Giovanni Zito and Mauro Manno",
year = "2015",
language = "English",
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TY - JOUR

T1 - Citrus limon-derived nanovesicles inhibit cancer cell proliferation and suppress CML xenograft growth by inducing TRAIL-mediated cell death

AU - Fontana, Simona

AU - Raimondo, Stefania

AU - Di Bella, Maria Antonietta

AU - Alessandro, Riccardo

AU - Naselli, Flores

AU - Lo Dico, Alessia

AU - Monteleone, Francesca

AU - Zito, Giovanni

AU - Saieva, Laura

AU - De Leo, Giacomo

AU - Manno, Mauro

AU - Zito, Giovanni

AU - Manno, Mauro

PY - 2015

Y1 - 2015

N2 - Nanosized vesicles are considered key players in cell to cell communication, thus influencing physiological and pathological processes, including cancer. Nanovesicles have also been found in edible-plants and have shown therapeutic activity in inflammatory bowel diseases; however information on their role in affecting cancer progression is missing.Our study identify for the first time a fraction of vesicles from lemon juice (Citrus limon L.), obtained as a result of different ultracentrifugation, with density ranging from 1,15 to 1,19 g/ml and specific proteomic profile. By using an in vitro approach, we show that isolated nanovesicles inhibit cancer cell proliferation in different tumor cell lines, by activating a TRAIL-mediated apoptotic cell death. Furthermore, we demonstrate that lemon nanovesicles suppress CML tumor growth in vivo by specifically reaching tumor site and by activating TRAIL-mediated apoptotic cell processes. Overall, this study suggests the possible use of plant-edible nanovesicles as a feasible approach in cancer treatment.

AB - Nanosized vesicles are considered key players in cell to cell communication, thus influencing physiological and pathological processes, including cancer. Nanovesicles have also been found in edible-plants and have shown therapeutic activity in inflammatory bowel diseases; however information on their role in affecting cancer progression is missing.Our study identify for the first time a fraction of vesicles from lemon juice (Citrus limon L.), obtained as a result of different ultracentrifugation, with density ranging from 1,15 to 1,19 g/ml and specific proteomic profile. By using an in vitro approach, we show that isolated nanovesicles inhibit cancer cell proliferation in different tumor cell lines, by activating a TRAIL-mediated apoptotic cell death. Furthermore, we demonstrate that lemon nanovesicles suppress CML tumor growth in vivo by specifically reaching tumor site and by activating TRAIL-mediated apoptotic cell processes. Overall, this study suggests the possible use of plant-edible nanovesicles as a feasible approach in cancer treatment.

KW - Citrus limon L.

KW - TRAIL-mediated cell death

KW - cancer

KW - exosome-like nanovesicles

UR - http://hdl.handle.net/10447/136552

M3 - Article

VL - 6

JO - Default journal

JF - Default journal

ER -