Citotoxic Saponins from Schefflera rotundifolia

Fabio Venturella; Nunziatina De Tommasi; Francesco De Simone; Alessandra Braca; Stefania Marzocco; Giuseppina Autore; Ivano Morelli

Citotoxic Saponins from Schefflera rotundifolia

Fabio Venturella, Nunziatina De Tommasi, Francesco De Simone, Alessandra Braca, Stefania Marzocco, Giuseppina Autore, Ivano Morelli

Scienze e Tecnologie Biologiche Chimiche e Farmaceutiche

Risultato della ricerca: Article › peer review

39 Citazioni (Scopus)

Abstract

Eight new oleanane and lupane saponins (1-8) as well as two new benzyl glycosides (9 and 10) were isolated from the aerial parts of Schefflera rotundifolia (Ten) Frodin (Araliaceae) together with two known benzyl glycosides. Their structures were established using 1D- and 2D-NMR spectroscopy and mass spectrometry. The antiproliferative activity of all compounds was evaluated using three continuous murine and human culture cell lines J774.A1, HEK-293, and WEHI-164. Compounds 7 and 8, having betulinic acid as aglycone, were the most active constituents

Lingua originale	English
pagine (da-a)	960-966
Rivista	Planta Medica
Volume	70
Stato di pubblicazione	Published - 2004

All Science Journal Classification (ASJC) codes

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???subjectarea.asjc.1300.1313???
???subjectarea.asjc.3000.3004???
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title = "Citotoxic Saponins from Schefflera rotundifolia",

abstract = "Eight new oleanane and lupane saponins (1-8) as well as two new benzyl glycosides (9 and 10) were isolated from the aerial parts of Schefflera rotundifolia (Ten) Frodin (Araliaceae) together with two known benzyl glycosides. Their structures were established using 1D- and 2D-NMR spectroscopy and mass spectrometry. The antiproliferative activity of all compounds was evaluated using three continuous murine and human culture cell lines J774.A1, HEK-293, and WEHI-164. Compounds 7 and 8, having betulinic acid as aglycone, were the most active constituents",

author = "Fabio Venturella and {De Tommasi}, Nunziatina and {De Simone}, Francesco and Alessandra Braca and Stefania Marzocco and Giuseppina Autore and Ivano Morelli",

year = "2004",

language = "English",

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journal = "Planta Medica",

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TY - JOUR

T1 - Citotoxic Saponins from Schefflera rotundifolia

AU - Venturella, Fabio

AU - De Tommasi, Nunziatina

AU - De Simone, Francesco

AU - Braca, Alessandra

AU - Marzocco, Stefania

AU - Autore, Giuseppina

AU - Morelli, Ivano

PY - 2004

Y1 - 2004

N2 - Eight new oleanane and lupane saponins (1-8) as well as two new benzyl glycosides (9 and 10) were isolated from the aerial parts of Schefflera rotundifolia (Ten) Frodin (Araliaceae) together with two known benzyl glycosides. Their structures were established using 1D- and 2D-NMR spectroscopy and mass spectrometry. The antiproliferative activity of all compounds was evaluated using three continuous murine and human culture cell lines J774.A1, HEK-293, and WEHI-164. Compounds 7 and 8, having betulinic acid as aglycone, were the most active constituents

AB - Eight new oleanane and lupane saponins (1-8) as well as two new benzyl glycosides (9 and 10) were isolated from the aerial parts of Schefflera rotundifolia (Ten) Frodin (Araliaceae) together with two known benzyl glycosides. Their structures were established using 1D- and 2D-NMR spectroscopy and mass spectrometry. The antiproliferative activity of all compounds was evaluated using three continuous murine and human culture cell lines J774.A1, HEK-293, and WEHI-164. Compounds 7 and 8, having betulinic acid as aglycone, were the most active constituents

UR - http://hdl.handle.net/10447/21385

M3 - Article

SN - 0032-0943

VL - 70

SP - 960

EP - 966

JO - Planta Medica

JF - Planta Medica

ER -

Citotoxic Saponins from Schefflera rotundifolia

Abstract

All Science Journal Classification (ASJC) codes

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