Circulating miRNAs in Successful and Unsuccessful Aging. A Mini-review

Giuseppina Candore, Simona Taverna, Alessia Lo Curto, Giovanni Duro, Giuseppe Cammarata

Risultato della ricerca: Articlepeer review

4 Citazioni (Scopus)


Aging is a multifactorial process that affects the organisms at genetic, molecular and cellular levels.This process modifies several tissues with a negative impact on cells physiology, tissues and organs functionality,altering their regeneration capacity. The chronic low-grade inflammation typical of aging, defined as inflammaging,is a common biological factor responsible for the decline and beginning of the disease in age. A murineparabiosis model that combines the vascular system of old and young animals, suggests that soluble factors releasedby young individuals may improve the regenerative potential of old tissue. Therefore, circulating factorshave a key role in the induction of aging phenotype. Moreover, lifestyle can influence the physiological status ofmultiple organs, via epigenetic mechanisms. Recently, microRNAs are considered potential sensors of aging.
Lingua originaleEnglish
pagine (da-a)4150-4153
Numero di pagine4
Stato di pubblicazionePublished - 2019

All Science Journal Classification (ASJC) codes

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