Circulating adiponectin: a cardiometabolic marker associated with global cardiovascular risk

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Abstract

OBJECTIVEThis study was designed to evaluate the relationship among circulating adiponectin (ADPN), left ventricular mass (LVM) and cardiometabolic comorbidities in subjects at higher global cardiovascular risk (score of “ Cuore Project “)METHODS.115 consecutive subjects were grouped according to normal or low ADPN levels. Left ventricular internal diameter (LVID/h), total LV mass (LVM), LVM index (LVMI), relative wall thickness (RWT), LV ejection fraction by echocardiography and diastolic parameters, by pulsed-wave Doppler were calculated. RESULTSLow-ADPN subjects were characterized by a significant higher prevalence of some cardiometabolic comorbidities (obesity, visceral obesity, diabetes and insulin resistance, LVH, Metabolic syndrome ( MetS),CAD). BMI (p<0.0001), WHR (p<0.03), triglycerides (p<0,001), HOMA-IR (p<0.001), LVM, LVMI, IVST and RWT (p< 0.0001) were significantly increased and HDL-C (p<0.001) and LVEF were significantly reduced in low-ADPN than normal-ADPN subjects. LVMI correlated directly with BMI (p<0.001), WHR (p<0.001) MBP (p<0.001), MetS (p<0.001) and inversely with ADPN ( p<0.0001). Mutiple regression analysis indicated that ADPN was independently associated to LVMI.CONCLUSIONS ADPN might be considered a key component that mediates the cross-talk between adipose tissue, cardiac cells and the vasculature. Accordingly, its routine measurement might become a new target in the management of global CV risk .
Lingua originaleEnglish
pagine (da-a)33-40
Numero di pagine8
RivistaActa Cardiologica
Volume70
Stato di pubblicazionePublished - 2015

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All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine

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