Circadian rhythm of COPD symptoms in clinically based phenotypes. Results from the STORICO Italian observational study

Nicola Scichilone, Anna Zedda, Walter Castellani, Luca Triolo, Giuseppina Cuttitta, Francesco Blasi, Maria Cristina Zappa, Francesco Blasi, Giorgio Walter Canonica, Gaetano Cabibbo, Riccardo Sarzani, Alessandra Ori, Michele Mastroberardino, Pasquale Patriciello, Alessandro Zullo, Walter Castellani, Antonio Iuliano, Federica Rivolta, Maria Pia Foschino, Luciana LabateDel Donno Mario, Federica Rivolta, Di Donato Salvatore Walter, Antonio Filippo Raco, Elena Atzeni, Lamberto Maggi, Di Re Luigi, Gaetano Cabibbo, Antonello Nicolini, Lo Cicero Salvatore, Giuseppe Sera, Piercarlo Giamesio, Luca Triolo, Stefano Nava, Francesco Blasi, Antonio Filippo Raco, Giuseppina Cuttitta, Titta, Walter Castellani, Pietro Schino, Mauro Ferliga, Roberto Tazza, Federica Rivolta, Enzo Faccini, Maria Pia Foschino, Carlo Gulotta, Bianca Beghè, Renato Prediletto, Alessandro Vatrella, Antonio Filippo Raco, Enrico Eugenio Guffanti, Carmelindo Mario Enrico Tranfa, Salvatore Mariotta, Rosario Maselli, Alberto Pesci, Stefano Nardini, Stefano Nava, Raffaele Antonelli Incalzi, Silvia Forte, Antonello Nicolini, Giovanni Passalacqua, Piercarlo Giamesio

Risultato della ricerca: Articlepeer review

1 Citazioni (Scopus)

Abstract

Background: Chronic Obstructive Pulmonary Disease (COPD) encompasses various phenotypes that severely limit the applicability of precision respiratory medicine. The present investigation is aimed to assess the circadian rhythm of symptoms in pre-defined clinical COPD phenotypes and its association with health-related quality of life (HR-QoL), the quality of sleep and the level of depression/anxiety in each clinical phenotype. Methods: The STORICO (NCT03105999) Italian observational prospective cohort study enrolled COPD subjects. A clinical diagnosis of either chronic bronchitis (CB), emphysema (EM) or mixed COPD-asthma (MCA) phenotype was made by clinicians at enrollment. Baseline early-morning, day-time and nocturnal symptoms (gathered via the Night-time, Morning and Day-time Symptoms of COPD questionnaire), HR-QoL (via the St. George's Respiratory Questionnaire), anxiety and depression levels (via the Hospital Anxiety and Depression Scale), quality of sleep (via COPD and Asthma Sleep Impact Scale), physical activity (via the International Physical Activity Questionnaire) as well as lung function were recorded. Results: 606 COPD subjects (age 71.4 ± 8.2 years, male 75.1%) were studied. 57.9, 35.5 5.3 and 1.3% of the sample belonged to the CB, EM, MCA and EM + CB phenotypes respectively. The vast majority of subjects reported early-morning and day-time symptoms (79.5 and 79.2% in the CB and 75.8 and 77.7% in the EM groups); the proportion suffering from night-time symptoms was higher in the CB than in the EM group (53.6% vs. 39.5%, p = 0.0016). In both CB and EM, indiscriminately, the presence of symptoms during the 24-h day was associated with poorer HR-QoL, worse quality of sleep and higher levels of anxiety/depression. Conclusions: The findings highlight the primary classificatory role of nocturnal symptoms in COPD. Trial registration: Trial registration number: NCT03105999, date of registration: 10th April 2017.
Lingua originaleEnglish
pagine (da-a)171-
Numero di pagine0
RivistaBMC Pulmonary Medicine
Volume19
Stato di pubblicazionePublished - 2019

All Science Journal Classification (ASJC) codes

  • ???subjectarea.asjc.2700.2740???

Fingerprint

Entra nei temi di ricerca di 'Circadian rhythm of COPD symptoms in clinically based phenotypes. Results from the STORICO Italian observational study'. Insieme formano una fingerprint unica.

Cita questo