Ciprofloxacin carrier systems based on hectorite/halloysite hybrid hydrogels for potential wound healing applications

Serena Riela, Giuseppe Cavallaro, Marina Massaro, Giuseppe Lazzara, Rita Sánchez-Espejo, Ana Borrego-Sánchez, Fátima García-Villén, Dalila Miele, Giuseppe Cavallaro, César Viseras Iborra, Susanna Guernelli, Giuseppe Lazzara, C. Ignacio Sainz-Díaz, Giuseppina Sandri

Risultato della ricerca: Articlepeer review

Abstract

The design of multifunctional nanomaterials which can help the healing processes of skin, preventing the bacterial infections, is crucial for the development of suitable therapy for the treatment of chronic lesions. The use of clay minerals in wound healing applications is well documented since the prehistoric period and offers several advantages due to their intrinsic properties. Herein, we report the development of ciprofloxacin carrier systems based on hectorite/halloysite (Ht/Hal) hybrid hydrogels for potential wound healing applications. To achieve this objective firstly the ciprofloxacin molecules were loaded onto Hal by a supramolecular and covalent approach. The so obtained fillers were thoroughly investigated by several techniques and at molecular level by means of quantum mechanics calculations along with empirical interatomic potentials. Afterwards the modified Hal were used as filler for Ht hydrogels. The introduction of modified Hal, in hectorite hydrogel, helps the gel formation with an improvement of the rheological properties. The in vitro kinetic release from both the fillers and from the hybrid hydrogels was studied both at skin's pH (5.4) and under neutral conditions (pH 7.4); in addition, the factors controlling the ciprofloxacin release process were determined and discussed. Finally, the in vitro biocompatibility of the Hal fillers was evaluated by means of cytotoxic assays and laser scanning confocal microscopy on normal human dermal fibroblasts.
Lingua originaleEnglish
pagine (da-a)1-12
Numero di pagine12
RivistaApplied Clay Science
Volume215
Stato di pubblicazionePublished - 2021

All Science Journal Classification (ASJC) codes

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