Ciona intestinalis interleukin 17-like genes expression is upregulated by LPS challenge

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25 Citazioni (Scopus)

Abstract

In humans, IL-17 is a proinflammatory cytokine that plays a key role in the clearance ofextracellular bacteria promoting cell infiltration and production of several cytokines andchemokines. Here, we report on three Ciona intestinalis IL-17 homologues (CiIL17-1, CiIL17-2,CiIL17-3). The gene organisation, phylogenetic tree and modelling supported the close relationshipwith the mammalian IL-17A and IL-17F suggesting that the C. intestinalis IL-17 genes share acommon ancestor in the chordate lineages. Real time PCR analysis showed a prompt expressioninduced by LPS inoculation suggesting that they are involved in the first phase of inflammatoryresponse. In situ hybridization assays disclosed that the genes transcription was upregulated in thepharynx, the main organ of the ascidian immune system, and expressed by hemocytes (granulocytesand univacuolar refractile granulocyte) inside the pharynx vessels.
Lingua originaleEnglish
pagine (da-a)129-137
Numero di pagine9
RivistaDevelopmental and Comparative Immunology
Volume48
Stato di pubblicazionePublished - 2015

All Science Journal Classification (ASJC) codes

  • Immunology
  • Developmental Biology

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