Cilomilast counteracts the effects of cigarette smoke in airway epithelial cells

Stefania La Grutta, Antonino Giarratano, Carina Gabriela Uasuf, Maria Ferraro, Malcolm Johnson, Mark Gjomarkaj, Giuseppe Liotta, Stefania La Grutta, Elisabetta Pace

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11 Citazioni (Scopus)

Abstract

Cigarette smoke extracts (CSE) alter TLR4 expression and activation in bronchial epithelial cells. Cilomilast, a phosphodiesterase-4 inhibitor, inhibits cigarette smoke-induced neutrophilia. This study was aimed to explore whether cilomilast, in a human bronchial epithelial cell line (16-HBE), counteracted CSE effects. In particular, TLR4 expression, IP-10 and IL-8 release, lymphocyte and neutrophil chemotactic activity and ERK and IkBa phosphorylation in CSE and LPS-stimulated 16-HBE were assessed. CSE increased TLR4 expression, reduced IP-10 release and lymphocyte chemotactic activity and increased IL-8 release and neutrophil chemotactic activity. Cilomilast reduced TLR4 expression, IL-8 release and neutrophil chemotactic activity as well as it increased IP-10 release and lymphocyte chemotactic activity. All these cilomilast mediated effects were associated with a reduced ERK1/2 and with an increased IkBa phosphorylation. In conclusion, the present study provides compelling evidences that cilomilast may be considered a possible valid therapeutic option in controlling inflammatory processes present in smokers.
Lingua originaleEnglish
pagine (da-a)47-53
Numero di pagine7
RivistaCellular Immunology
Volume268
Stato di pubblicazionePublished - 2011

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All Science Journal Classification (ASJC) codes

  • Immunology

Cita questo

La Grutta, S., Giarratano, A., Uasuf, C. G., Ferraro, M., Johnson, M., Gjomarkaj, M., Liotta, G., Grutta, S. L., & Pace, E. (2011). Cilomilast counteracts the effects of cigarette smoke in airway epithelial cells. Cellular Immunology, 268, 47-53.