Cigarette smoking is associated with decreased Bone Gla-Protein (BGP) levels in hemodialysis patients

Nicola Veronese, Andrea Stucchi, Laura Cosmai, Giovanni Tripepi, Nicola Veronese, Sandro Giannini, Michela Spinello, Andrea Aghi, Fiorenza Magonara, Alberto Ferraro, Maria A. Rizzo, Mario Plebani, Marianna Noale, Thomas Nickolas, Maria C. Mereu, Maria Fusaro, Giorgio Iervasi, Maurizio Gallieni, Antonio Piccoli, Lorenzo CalòFabrizio Fabris, Stefania Sella

Risultato della ricerca: Articlepeer review

2 Citazioni (Scopus)

Abstract

Background: Bone Gamma-carboxyglutamic acid (Gla)-protein (BGP or osteocalcin) is a vitamin K-dependent protein involved in the regulation of bone mineralization. Smoking is a risk factor for osteoporosis. Methods: We carried out a secondary analysis of the Vitamin K Italian (VIKI) study to investigate the association between cigarette smoking and BGP levels in patients with end stage renal disease. Data were collected in 370 haemodialysis patients, 37% (136) smokers (or ex-smokers) and 63% (234) nonsmokers. Vascular calcifications and vertebral fractures (quantitative morphometry) were identified on spine radiographs. Results: Smokers had significantly lower BGP levels (152 vs. 204 μg/L, p=0.003). Smokers had lower plasma phosphate levels (4.2 vs. 4.7 mg/dl, p<0.01). Lower BGP levels were associated with aortic calcification (p<0.001), iliac calcification (p=0.042) and vertebral fractures (p=0.023). In addition, the regression model showed that smoking is associated with a significant reduction of total BGP levels by about 18% (p=0.01). Conclusion: This is the first clinical study in a haemodialysis population, which identifies cigarette smoking as a potential factor that can lower BGP levels, a protective agent in bone and vascular health. © 2018 Bentham Science Publishers.
Lingua originaleEnglish
pagine (da-a)603-609
Numero di pagine7
RivistaCurrent Vascular Pharmacology
Volume16
Stato di pubblicazionePublished - 2018

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Cardiology and Cardiovascular Medicine

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