Chronic pharmacological treatment in takotsubo cardiomyopathy

Giuseppina Novo, Salvatore Novo, Gaspare Barbaro, Giovanna Evola, Giuseppe Barbaro, Salvatore Azzarelli, Tomas Palecek, Giuseppe Barbaro, Yoshihiro J. Akashi, Caterina Cascio, Caterina Pizzuto, Egle Incalcaterra, Gabriele Di Gesaro, Giovanni Fazio

Risultato della ricerca: Article

45 Citazioni (Scopus)

Abstract

Noncompaction of the ventricular myocardium (LVNC) is a rare congenital cardiomyopathy resulting from an arrest in normal endomyocardial embryogenesis. In 2002 Jenni et al. [Jenni R, Wyss CA, Oechslin EN, Kaufmann PA. Isolated ventricular noncompaction is associated with coronary microcirculatory dysfunction. J Am Coll Cardiol 2002; 39:450-454.] reported a microvascular dysfunction in 12 patients affected by non compaction: areas of restricted myocardial perfusion have been documented by scintigraphy, suggesting a reduction of Coronary flow reserve. McMahon et al reported in a recent article a reduction of TD velocities in children with noncompaction of the left ventricle, compared with normal controls. The authors concluded their work saying that the reduction of lateral mitral Ea velocity helps to predict children with LVNC who are at risk of adverse clinical outcomes including death and need for cardiac transplantation. In a precedent report our group reported a strong correlation between pathological tissue Doppler and reduction of ejection fraction. Recently we scanned with a Signa HD 1.5 T (GE, Milwaukee, USA) 8 patients affected by non compaction. Transmural Gd-enhancement was detected in 5/8 patients (62%). In all patients with late enhancement a reduction of EF has demonstrated. In our opinion the late enhancement can depend on a CFR, and is the determinant of the tissue Doppler alterations. So the TD alteration is associated with EF, and is an indirect index of poor clinical outcome, like EF.
Lingua originaleEnglish
pagine (da-a)121-123
Numero di pagine3
RivistaINTERNATIONAL JOURNAL OF CARDIOLOGY
Volume127
Stato di pubblicazionePublished - 2008

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Takotsubo Cardiomyopathy
Pharmacology
Heart Transplantation
Therapeutics
Cardiomyopathies
Radionuclide Imaging
Heart Ventricles
Embryonic Development
Myocardium
Perfusion

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine

Cita questo

Chronic pharmacological treatment in takotsubo cardiomyopathy. / Novo, Giuseppina; Novo, Salvatore; Barbaro, Gaspare; Evola, Giovanna; Barbaro, Giuseppe; Azzarelli, Salvatore; Palecek, Tomas; Barbaro, Giuseppe; Akashi, Yoshihiro J.; Cascio, Caterina; Pizzuto, Caterina; Incalcaterra, Egle; Di Gesaro, Gabriele; Fazio, Giovanni.

In: INTERNATIONAL JOURNAL OF CARDIOLOGY, Vol. 127, 2008, pag. 121-123.

Risultato della ricerca: Article

Novo, G, Novo, S, Barbaro, G, Evola, G, Barbaro, G, Azzarelli, S, Palecek, T, Barbaro, G, Akashi, YJ, Cascio, C, Pizzuto, C, Incalcaterra, E, Di Gesaro, G & Fazio, G 2008, 'Chronic pharmacological treatment in takotsubo cardiomyopathy', INTERNATIONAL JOURNAL OF CARDIOLOGY, vol. 127, pagg. 121-123.
Novo, Giuseppina ; Novo, Salvatore ; Barbaro, Gaspare ; Evola, Giovanna ; Barbaro, Giuseppe ; Azzarelli, Salvatore ; Palecek, Tomas ; Barbaro, Giuseppe ; Akashi, Yoshihiro J. ; Cascio, Caterina ; Pizzuto, Caterina ; Incalcaterra, Egle ; Di Gesaro, Gabriele ; Fazio, Giovanni. / Chronic pharmacological treatment in takotsubo cardiomyopathy. In: INTERNATIONAL JOURNAL OF CARDIOLOGY. 2008 ; Vol. 127. pagg. 121-123.
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AU - Palecek, Tomas

AU - Barbaro, Giuseppe

AU - Akashi, Yoshihiro J.

AU - Cascio, Caterina

AU - Pizzuto, Caterina

AU - Incalcaterra, Egle

AU - Di Gesaro, Gabriele

AU - Fazio, Giovanni

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AB - Noncompaction of the ventricular myocardium (LVNC) is a rare congenital cardiomyopathy resulting from an arrest in normal endomyocardial embryogenesis. In 2002 Jenni et al. [Jenni R, Wyss CA, Oechslin EN, Kaufmann PA. Isolated ventricular noncompaction is associated with coronary microcirculatory dysfunction. J Am Coll Cardiol 2002; 39:450-454.] reported a microvascular dysfunction in 12 patients affected by non compaction: areas of restricted myocardial perfusion have been documented by scintigraphy, suggesting a reduction of Coronary flow reserve. McMahon et al reported in a recent article a reduction of TD velocities in children with noncompaction of the left ventricle, compared with normal controls. The authors concluded their work saying that the reduction of lateral mitral Ea velocity helps to predict children with LVNC who are at risk of adverse clinical outcomes including death and need for cardiac transplantation. In a precedent report our group reported a strong correlation between pathological tissue Doppler and reduction of ejection fraction. Recently we scanned with a Signa HD 1.5 T (GE, Milwaukee, USA) 8 patients affected by non compaction. Transmural Gd-enhancement was detected in 5/8 patients (62%). In all patients with late enhancement a reduction of EF has demonstrated. In our opinion the late enhancement can depend on a CFR, and is the determinant of the tissue Doppler alterations. So the TD alteration is associated with EF, and is an indirect index of poor clinical outcome, like EF.

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