Chronic kidney disease and inflammation: Role of +896A/G pro-inflammatory polymorphism of TLR4 gene and Δ32 deletion of CCR5 gene

Iatrino, R

Risultato della ricerca: Article

1 Citazione (Scopus)

Abstract

bstract Chronic inflammation seems implicated in the pathophysiology of chronic kidney diseases (CKD) and the development of its complications, such as cardiovascular diseases (CVD). Genes encoding inflammatory molecules are, hence, good candidates for CVD risk in haemodialysis patients (HD). We therefore evaluated whether +896A/G TLR4 polymorphism and CCR5A32 deletion are risk factors for CKD and CVD. We examined the two gene variants in 72 HD patients and in 125 controls from Sicily. No significant differences in the genotype distribution and allele frequencies of the two gene variants were observed between patients and controls. The same results were obtained by analysing the combined effect of the two proinflammatory (+896ATLR4 and wt CCR5) alleles. However, the high responder proinflammatory (+896A+TLR4/wt+CCR5) genotype seems to be a possible independent risk factor for CVD development in HD patients. Our results suggest that HD patients with a high responder proinflammatory genotype have an increase CVD risk. Copyright © by BIOLIFE, s.a.s
Lingua originaleEnglish
pagine (da-a)191-194
Numero di pagine4
RivistaEuropean Journal of Inflammation
Volume7
Stato di pubblicazionePublished - 2009

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Gene Deletion
Chronic Renal Insufficiency
Inflammation
Cardiovascular Diseases
Genes
Renal Dialysis
Genotype
Sicily
Gene Frequency
Alleles

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology

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title = "Chronic kidney disease and inflammation: Role of +896A/G pro-inflammatory polymorphism of TLR4 gene and Δ32 deletion of CCR5 gene",
abstract = "bstract Chronic inflammation seems implicated in the pathophysiology of chronic kidney diseases (CKD) and the development of its complications, such as cardiovascular diseases (CVD). Genes encoding inflammatory molecules are, hence, good candidates for CVD risk in haemodialysis patients (HD). We therefore evaluated whether +896A/G TLR4 polymorphism and CCR5A32 deletion are risk factors for CKD and CVD. We examined the two gene variants in 72 HD patients and in 125 controls from Sicily. No significant differences in the genotype distribution and allele frequencies of the two gene variants were observed between patients and controls. The same results were obtained by analysing the combined effect of the two proinflammatory (+896ATLR4 and wt CCR5) alleles. However, the high responder proinflammatory (+896A+TLR4/wt+CCR5) genotype seems to be a possible independent risk factor for CVD development in HD patients. Our results suggest that HD patients with a high responder proinflammatory genotype have an increase CVD risk. Copyright {\circledC} by BIOLIFE, s.a.s",
author = "{Iatrino, R} and Calogero Caruso and {Li Vecchi}, Maurizio and Giuseppina Candore and Egle Incalcaterra and Balistreri, {Carmela Rita} and Marco Caruso",
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T1 - Chronic kidney disease and inflammation: Role of +896A/G pro-inflammatory polymorphism of TLR4 gene and Δ32 deletion of CCR5 gene

AU - Iatrino, R

AU - Caruso, Calogero

AU - Li Vecchi, Maurizio

AU - Candore, Giuseppina

AU - Incalcaterra, Egle

AU - Balistreri, Carmela Rita

AU - Caruso, Marco

N1 - nonValidatingUrl:ISSN: 1721727X

PY - 2009

Y1 - 2009

N2 - bstract Chronic inflammation seems implicated in the pathophysiology of chronic kidney diseases (CKD) and the development of its complications, such as cardiovascular diseases (CVD). Genes encoding inflammatory molecules are, hence, good candidates for CVD risk in haemodialysis patients (HD). We therefore evaluated whether +896A/G TLR4 polymorphism and CCR5A32 deletion are risk factors for CKD and CVD. We examined the two gene variants in 72 HD patients and in 125 controls from Sicily. No significant differences in the genotype distribution and allele frequencies of the two gene variants were observed between patients and controls. The same results were obtained by analysing the combined effect of the two proinflammatory (+896ATLR4 and wt CCR5) alleles. However, the high responder proinflammatory (+896A+TLR4/wt+CCR5) genotype seems to be a possible independent risk factor for CVD development in HD patients. Our results suggest that HD patients with a high responder proinflammatory genotype have an increase CVD risk. Copyright © by BIOLIFE, s.a.s

AB - bstract Chronic inflammation seems implicated in the pathophysiology of chronic kidney diseases (CKD) and the development of its complications, such as cardiovascular diseases (CVD). Genes encoding inflammatory molecules are, hence, good candidates for CVD risk in haemodialysis patients (HD). We therefore evaluated whether +896A/G TLR4 polymorphism and CCR5A32 deletion are risk factors for CKD and CVD. We examined the two gene variants in 72 HD patients and in 125 controls from Sicily. No significant differences in the genotype distribution and allele frequencies of the two gene variants were observed between patients and controls. The same results were obtained by analysing the combined effect of the two proinflammatory (+896ATLR4 and wt CCR5) alleles. However, the high responder proinflammatory (+896A+TLR4/wt+CCR5) genotype seems to be a possible independent risk factor for CVD development in HD patients. Our results suggest that HD patients with a high responder proinflammatory genotype have an increase CVD risk. Copyright © by BIOLIFE, s.a.s

UR - http://hdl.handle.net/10447/75381

M3 - Article

VL - 7

SP - 191

EP - 194

JO - European Journal of Inflammation

JF - European Journal of Inflammation

SN - 1721-727X

ER -